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The map label for this gene is pyrD [H]

Identifier: 123967754

GI number: 123967754

Start: 202905

End: 204074

Strand: Reverse

Name: pyrD [H]

Synonym: A9601_02171

Alternate gene names: 123967754

Gene position: 204074-202905 (Counterclockwise)

Preceding gene: 123967755

Following gene: 123967753

Centisome position: 12.22

GC content: 30.43

Gene sequence:

>1170_bases
ATGAATGAACAGAAGGGTGGATTTAAAAATCTTTATAAAAACTTGATTACCCCTGTATTACAAAAAGACTCTGGAATTGA
TGCAGAATACTTAACAAATTTATCTCTTAGTCTCCTATCATTCAGTTCAAGAAAATATAATTGGCCTATAGTATCTTCTA
TCTTAAAAAATCTAAATGAAGAATTTTCTGTAGTTGATAAAAGGTTAACTCAGAAGATATGTGGAATAAATTTTTGTAAT
CCAATTGGTTTAGCTGCGGGTTTTGACAAAAATGGAAATGCCGCAAATATATGGAAAGATTTTGGTTTTGGATTTGCTGA
GCTTGGAACAGTAACTAAATTTGCTCAGGATGGAAATCCCAAACCAAGGTTATTTAGATTGGCAGAAGAAGAAGCAGCAT
TAAATAGAATGGGTTTCAATAATAATGGTGCTGAAAATCTAGTTAAAAACTTTGTCGAACAAGGTATTGAGTTTAAAAAA
AACAGGGAGAATATTTGTTTAGGGATAAATTTCGGGAAGTCAAAAATTACAGGTTTATCTCAAGCAAAAGATGATTATTT
AACTTCTCTAAAATTATTAATTCCATATTGTGATTACGCAGCAATAAACGTTAGTTCTCCAAATACTGAAGGACTAAGAA
AATTACAAGATCCAATTCTTCTAAAAGAACTTCTTAGAGAAATTAAAAACTTACCTAATTGTCCACCATTATTTGTAAAA
ATTGCACCAGATTTAGGCCTTAAAGATATTGAAGATATTTGCAAATTAATAATCGAGGAGAACATCGATGGAATAATTGC
TACAAATACCAGCATTGATAGATTAGGTCTTGAAAATAGAAAAATCAAGCAAACTGGATTATTACTCTCTCAAGAGAATG
GAGGATTAAGTGGAAAGCCGCTCCAAAAAAAAGCAAATCAAATAATAAAACATATACATAATATTGATAAAAAGATTATT
TTAATTGGGGTTGGTGGAATAGATAGTCCTGAGTCAGCTTGGGAAAGAATTTGTTCTGGAGCATCATTAATTCAACTTTA
TACAGGATGGATATATAAGGGTCCACAATTAGTACCAGATATACTTGAGGGAATTATAAAGCAACTCAATAACCATCAAT
TATCTAGTATAAAAGATGCAATTGGATCAGATTTAAAATGGATTGAATAA

Upstream 100 bases:

>100_bases
AAAGATAAAACAATATTCACTTTTTGAATGGCGTAATTGGATATTGATTCCTAAAGATAAAAAATATTGGATAATAGAAA
AAAAAGAAGCCTAATTTTTT

Downstream 100 bases:

>100_bases
AATTAGAGAATGAATAATGAACCTCATGATTACTCAACGTTAGCCATGCAAGGATCAAACTTGAAGCACGGTGGAAATGT
ATATGCAATTGCGAAAAAAT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MNEQKGGFKNLYKNLITPVLQKDSGIDAEYLTNLSLSLLSFSSRKYNWPIVSSILKNLNEEFSVVDKRLTQKICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQDGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFVEQGIEFKK
NRENICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLREIKNLPNCPPLFVK
IAPDLGLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIKQTGLLLSQENGGLSGKPLQKKANQIIKHIHNIDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPDILEGIIKQLNNHQLSSIKDAIGSDLKWIE

Sequences:

>Translated_389_residues
MNEQKGGFKNLYKNLITPVLQKDSGIDAEYLTNLSLSLLSFSSRKYNWPIVSSILKNLNEEFSVVDKRLTQKICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQDGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFVEQGIEFKK
NRENICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLREIKNLPNCPPLFVK
IAPDLGLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIKQTGLLLSQENGGLSGKPLQKKANQIIKHIHNIDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPDILEGIIKQLNNHQLSSIKDAIGSDLKWIE
>Mature_389_residues
MNEQKGGFKNLYKNLITPVLQKDSGIDAEYLTNLSLSLLSFSSRKYNWPIVSSILKNLNEEFSVVDKRLTQKICGINFCN
PIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQDGNPKPRLFRLAEEEAALNRMGFNNNGAENLVKNFVEQGIEFKK
NRENICLGINFGKSKITGLSQAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLREIKNLPNCPPLFVK
IAPDLGLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIKQTGLLLSQENGGLSGKPLQKKANQIIKHIHNIDKKII
LIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPDILEGIIKQLNNHQLSSIKDAIGSDLKWIE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=327, Percent_Identity=40.0611620795107, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI119943098, Length=332, Percent_Identity=23.7951807228916, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787177, Length=300, Percent_Identity=45.6666666666667, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI87082059, Length=334, Percent_Identity=24.8502994011976, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509475, Length=393, Percent_Identity=35.1145038167939, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI281361352, Length=336, Percent_Identity=39.5833333333333, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI17137316, Length=336, Percent_Identity=39.5833333333333, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 43183; Mature: 43183

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEQKGGFKNLYKNLITPVLQKDSGIDAEYLTNLSLSLLSFSSRKYNWPIVSSILKNLNE
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFSVVDKRLTQKICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQDGNP
HHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAEEEAALNRMGFNNNGAENLVKNFVEQGIEFKKNRENICLGINFGKSKITGLS
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEEECCHHHHCCHH
QAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLREIKNLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEE
IAPDLGLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIKQTGLLLSQENGGLSGKP
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCHHHHHCCEEECCCCCCCCCC
LQKKANQIIKHIHNIDKKIILIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPD
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
ILEGIIKQLNNHQLSSIKDAIGSDLKWIE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNEQKGGFKNLYKNLITPVLQKDSGIDAEYLTNLSLSLLSFSSRKYNWPIVSSILKNLNE
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EFSVVDKRLTQKICGINFCNPIGLAAGFDKNGNAANIWKDFGFGFAELGTVTKFAQDGNP
HHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCC
KPRLFRLAEEEAALNRMGFNNNGAENLVKNFVEQGIEFKKNRENICLGINFGKSKITGLS
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHCCCCCCEEEEEECCHHHHCCHH
QAKDDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLKELLREIKNLPNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEE
IAPDLGLKDIEDICKLIIEENIDGIIATNTSIDRLGLENRKIKQTGLLLSQENGGLSGKP
ECCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCHHHHHCCEEECCCCCCCCCC
LQKKANQIIKHIHNIDKKIILIGVGGIDSPESAWERICSGASLIQLYTGWIYKGPQLVPD
HHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
ILEGIIKQLNNHQLSSIKDAIGSDLKWIE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]