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The map label for this gene is hisC [H]

Identifier: 123967741

GI number: 123967741

Start: 186926

End: 188035

Strand: Reverse

Name: hisC [H]

Synonym: A9601_02041

Alternate gene names: 123967741

Gene position: 188035-186926 (Counterclockwise)

Preceding gene: 123967742

Following gene: 123967734

Centisome position: 11.26

GC content: 27.12

Gene sequence:

>1110_bases
ATGAATGATTTTGATCCATTAAATAATCTTTTCCCAAAACCAAGAGAAGAAATAATAAATATGCAGTCTTACTCTGCACC
TTTAGAAAATAGAAGAAATTTACTCCGCTTAGACTTTAATGAAAATACTTTAGGTCCAAGTCCTAAGGTTCTAGAGGCAT
TAAAAGCGATAAAATTAGATGAGATTTCAATTTATCCAGAATATAATTTTTTAAAAAAATATTTATGTGATAAATATCTT
GATTCAAGAAAATTTGGTAATGATGAAATCGGAATTTTCAATGGAGCAGATGCAGCAATAAATGCAATTTTCAATTGCTT
TGGAGAAAAAGATCAAATATTTCTAACCACAAATCCAACTTTTGGTTACTATTCTCCTTGTGCAGAAATCCGAGGAATGA
AAAAAATAAGTTGTTCTTACATTGGAGAAAATTTTCTATTCCCCATCGAAGAATTTAGGGAAAAAATAATAAAGCATAAT
CCAAAGTTAATATTTATTTGCAATCCAAATAATCCAACAGGAACTGTTCTAAGCTCTCATGAAATAATTAATTTAGCCAA
TATCAATAAAGATTCATTAATAGTTGTTGATGAACTATATGAAAAATTTAATGGAGATAGTCTTCTTAAATCGATAGATT
TTGAAAAAAATAAAAATATACTAATAATACAATCTCTTTCAAAAACTGCAGGTCTAGCTGGTTTAAGAATAGGTTTTACT
TTTGGCAATAAAAGTTTAATTCAGTACATTAATAAAGTTACAGGACCATATGATGTAAACAGCTTTGCTATAACAGCTGC
ATTAGCAGCACTTAAAGACAAATCATATATTGATAATTATGTTTTAGAAGTAAAAAAGGCGAGGGAATGGATTTTAAATA
AATTTAAATCAACAAAAATCAGAACTCACTTTAGTGGAGGTAATTATTTCTTAATTTGGCCAAAAAAAGATCCTAAAATC
TTAATACAACAGATGAGAGCAAAAGGTATTCTTATTAGAAGTATGGAAAACAAAAAAGATATCAGTAATTCTATAAGGGT
TAGTATTGGAACTAAAGAACAAATGATTTTTTTCTGGGACAATTACAAGATATTAGATTTAAAAAATTAA

Upstream 100 bases:

>100_bases
AAAATATAAAAATTTCTAGGCTTAATTTATGTGACCTAACTGCAAAAACACTAAAATTAAGCTTAGAGATTTTAGGAATT
GAAACTTTAGAAAGAATGTA

Downstream 100 bases:

>100_bases
TTACTGAAAATATAAATTGTATTTTGATCGATTCTTTTAGGTTTTATTTGAAAATTTTTTCCAACATATTTTACTTTAAA
ATCTTTCATATTTTCGATAA

Product: aminotransferases class-I

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNDFDPLNNLFPKPREEIINMQSYSAPLENRRNLLRLDFNENTLGPSPKVLEALKAIKLDEISIYPEYNFLKKYLCDKYL
DSRKFGNDEIGIFNGADAAINAIFNCFGEKDQIFLTTNPTFGYYSPCAEIRGMKKISCSYIGENFLFPIEEFREKIIKHN
PKLIFICNPNNPTGTVLSSHEIINLANINKDSLIVVDELYEKFNGDSLLKSIDFEKNKNILIIQSLSKTAGLAGLRIGFT
FGNKSLIQYINKVTGPYDVNSFAITAALAALKDKSYIDNYVLEVKKAREWILNKFKSTKIRTHFSGGNYFLIWPKKDPKI
LIQQMRAKGILIRSMENKKDISNSIRVSIGTKEQMIFFWDNYKILDLKN

Sequences:

>Translated_369_residues
MNDFDPLNNLFPKPREEIINMQSYSAPLENRRNLLRLDFNENTLGPSPKVLEALKAIKLDEISIYPEYNFLKKYLCDKYL
DSRKFGNDEIGIFNGADAAINAIFNCFGEKDQIFLTTNPTFGYYSPCAEIRGMKKISCSYIGENFLFPIEEFREKIIKHN
PKLIFICNPNNPTGTVLSSHEIINLANINKDSLIVVDELYEKFNGDSLLKSIDFEKNKNILIIQSLSKTAGLAGLRIGFT
FGNKSLIQYINKVTGPYDVNSFAITAALAALKDKSYIDNYVLEVKKAREWILNKFKSTKIRTHFSGGNYFLIWPKKDPKI
LIQQMRAKGILIRSMENKKDISNSIRVSIGTKEQMIFFWDNYKILDLKN
>Mature_369_residues
MNDFDPLNNLFPKPREEIINMQSYSAPLENRRNLLRLDFNENTLGPSPKVLEALKAIKLDEISIYPEYNFLKKYLCDKYL
DSRKFGNDEIGIFNGADAAINAIFNCFGEKDQIFLTTNPTFGYYSPCAEIRGMKKISCSYIGENFLFPIEEFREKIIKHN
PKLIFICNPNNPTGTVLSSHEIINLANINKDSLIVVDELYEKFNGDSLLKSIDFEKNKNILIIQSLSKTAGLAGLRIGFT
FGNKSLIQYINKVTGPYDVNSFAITAALAALKDKSYIDNYVLEVKKAREWILNKFKSTKIRTHFSGGNYFLIWPKKDPKI
LIQQMRAKGILIRSMENKKDISNSIRVSIGTKEQMIFFWDNYKILDLKN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=296, Percent_Identity=26.0135135135135, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=27.2, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42358; Mature: 42358

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFDPLNNLFPKPREEIINMQSYSAPLENRRNLLRLDFNENTLGPSPKVLEALKAIKLD
CCCCCCHHHCCCCCHHHHHCHHHCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCC
EISIYPEYNFLKKYLCDKYLDSRKFGNDEIGIFNGADAAINAIFNCFGEKDQIFLTTNPT
EEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCC
FGYYSPCAEIRGMKKISCSYIGENFLFPIEEFREKIIKHNPKLIFICNPNNPTGTVLSSH
CCCCCCHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEECC
EIINLANINKDSLIVVDELYEKFNGDSLLKSIDFEKNKNILIIQSLSKTAGLAGLRIGFT
CEEEEECCCCCCEEEHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEE
FGNKSLIQYINKVTGPYDVNSFAITAALAALKDKSYIDNYVLEVKKAREWILNKFKSTKI
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEE
RTHFSGGNYFLIWPKKDPKILIQQMRAKGILIRSMENKKDISNSIRVSIGTKEQMIFFWD
EEEECCCCEEEEECCCCHHHHHHHHHHCCEEEEECCCHHCCCCCEEEEECCCCEEEEEEC
NYKILDLKN
CEEEEEECC
>Mature Secondary Structure
MNDFDPLNNLFPKPREEIINMQSYSAPLENRRNLLRLDFNENTLGPSPKVLEALKAIKLD
CCCCCCHHHCCCCCHHHHHCHHHCCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCC
EISIYPEYNFLKKYLCDKYLDSRKFGNDEIGIFNGADAAINAIFNCFGEKDQIFLTTNPT
EEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCC
FGYYSPCAEIRGMKKISCSYIGENFLFPIEEFREKIIKHNPKLIFICNPNNPTGTVLSSH
CCCCCCHHHHCCCCEEEHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEECC
EIINLANINKDSLIVVDELYEKFNGDSLLKSIDFEKNKNILIIQSLSKTAGLAGLRIGFT
CEEEEECCCCCCEEEHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEE
FGNKSLIQYINKVTGPYDVNSFAITAALAALKDKSYIDNYVLEVKKAREWILNKFKSTKI
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEE
RTHFSGGNYFLIWPKKDPKILIQQMRAKGILIRSMENKKDISNSIRVSIGTKEQMIFFWD
EEEECCCCEEEEECCCCHHHHHHHHHHCCEEEEECCCHHCCCCCEEEEECCCCEEEEEEC
NYKILDLKN
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA