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The map label for this gene is ndhH [H]

Identifier: 123967727

GI number: 123967727

Start: 175806

End: 176993

Strand: Direct

Name: ndhH [H]

Synonym: A9601_01901

Alternate gene names: 123967727

Gene position: 175806-176993 (Clockwise)

Preceding gene: 123967725

Following gene: 123967728

Centisome position: 10.53

GC content: 36.53

Gene sequence:

>1188_bases
ATGGCTCAGCTAGAGACTAGAACAGAACCAATGGTGGTCAATTTTGGCCCTCACCATCCCTCAATGCATGGTGTTTTAAG
GTTAGTTGTAACTCTTGATGGTGAGAATGTCATTGATTGCGAGCCAGTAATTGGATATTTACACAGAGGAATGGAAAAAA
TAGCTGAAAATAGGACAAATGTAATGTATGTCCCTTATGTAAGCAGAATGGATTATGCCGCAGGAATGTTTTATGAAGCT
ATTGTAGTAAATGCTCCTGAAAGATTAGCTAATATTCCAGTTCCCAAAAGAGCTAGTTACATCAGAGTTCTTATGCTCGA
ACTTAATCGTATTGCTAATCATCTTTTATGGCTTGGTCCCTTTTTAGCAGACGTTGGAGCTCAAACTCCATTTTTCTATA
TCTTTAGAGAAAGAGAGATGATCTATGATCTCTGGGAAGCTGCTACTGGACAAAGGCTAATAAATAATAATTTCTTTAGA
ATAGGTGGAGTAGCATGTGATCTCCCATACGGATGGTTAGAAAAATGTATAGACTTTTGCGATTGGTTCGGTCCGAAGAT
AGATGAATACGAAAAATTAATCACAAATAATCCAATTTTTAAAAAAAGAATTGAAGGTTTAGGAACAATACAAAGAGACC
AGGCAATTAATTGGTCTTTGTCTGGGCCAATGCTTAGAGCTTCTGGGGTTTCATGGGATTTAAGGAAAGTCGATAGTTAT
GAATGTTATGACGATTTTGATTGGCAGATTGCTTCTGAAAAAGAAGGAGATTGTTATGCGAGATATCGAGTAAGAGTTGA
AGAGATGAGACAATCACTAAGTATCATTCGCCAAGCCTGCAAAATGATTCCAGGAGGCCCAACAGAAAATTTAGAAGCTC
AAAGAATGGTGACTGAAGATAAGAAAAGTGAAATATTCGGTATTGACTACCAATATGTAGCTAAGAAGGTTGCTCCAACT
TTTAAAATTCCTAATGGAGAATTATACACAAGATTAGAGTCCGGCAAAGGAGAAATAGGTGTTTTTATTCAAGGAAATAA
TGAAGTTACCCCATGGAGATTCAAAATCAGAGCAGCTGATTTAAATAATCTGCAAATATTGCCTCATATTCTTAAAGGTG
CCAAAATCGCTGATATTATGGCAATCCTTGGATCAATAGATGTCATTATGGGATCTGTTGATAGATAA

Upstream 100 bases:

>100_bases
ATCTCATCTGTCATAACTGATTGATGATTGAAAAAAGATGAATCAGATAGGTCAGTTTGCATAACTTTCGACTAAGATTT
GTGTAGAAGTTAAATTTGGA

Downstream 100 bases:

>100_bases
TTTCTTTAAATGAAACCCGCTGACTGGTTAATATTGCAGAAGAAGGTAAGATTTGGTGATTGTGATTCTGCAGGTGTAAT
TCATTTTCATAACTTATTAA

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTNVMYVPYVSRMDYAAGMFYEA
IVVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFR
IGGVACDLPYGWLEKCIDFCDWFGPKIDEYEKLITNNPIFKKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSY
ECYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMVTEDKKSEIFGIDYQYVAKKVAPT
FKIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAADLNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR

Sequences:

>Translated_395_residues
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTNVMYVPYVSRMDYAAGMFYEA
IVVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFR
IGGVACDLPYGWLEKCIDFCDWFGPKIDEYEKLITNNPIFKKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSY
ECYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMVTEDKKSEIFGIDYQYVAKKVAPT
FKIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAADLNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR
>Mature_394_residues
AQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTNVMYVPYVSRMDYAAGMFYEAI
VVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGPFLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFRI
GGVACDLPYGWLEKCIDFCDWFGPKIDEYEKLITNNPIFKKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSYE
CYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMVTEDKKSEIFGIDYQYVAKKVAPTF
KIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAADLNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=393, Percent_Identity=40.2035623409669, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI260898743, Length=387, Percent_Identity=39.5348837209302, Blast_Score=279, Evalue=4e-75,
Organism=Escherichia coli, GI145693162, Length=391, Percent_Identity=38.8746803069054, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1789076, Length=388, Percent_Identity=29.3814432989691, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788832, Length=395, Percent_Identity=27.3417721518987, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17568379, Length=396, Percent_Identity=39.3939393939394, Blast_Score=298, Evalue=3e-81,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=39.5939086294416, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=39.8477157360406, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=39.5833333333333, Blast_Score=310, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: 1.6.5.3

Molecular weight: Translated: 45180; Mature: 45049

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTN
CCCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCCCCC
VMYVPYVSRMDYAAGMFYEAIVVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGP
EEEECCHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFRIGGVACDLPYGWLEKCIDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFKKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSY
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCEEHHCCCCC
ECYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMVTED
CCCCCCCCEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
KKSEIFGIDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAAD
CCCCEECCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECC
LNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AQLETRTEPMVVNFGPHHPSMHGVLRLVVTLDGENVIDCEPVIGYLHRGMEKIAENRTN
CCCCCCCCCEEEEECCCCCCHHEEEEEEEEECCCCEEECHHHHHHHHHHHHHHHCCCCC
VMYVPYVSRMDYAAGMFYEAIVVNAPERLANIPVPKRASYIRVLMLELNRIANHLLWLGP
EEEECCHHHHHHHHHHHHHHHEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYIFREREMIYDLWEAATGQRLINNNFFRIGGVACDLPYGWLEKCIDFC
HHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCEEECCEEEECCHHHHHHHHHHH
DWFGPKIDEYEKLITNNPIFKKRIEGLGTIQRDQAINWSLSGPMLRASGVSWDLRKVDSY
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCEEEECCCCEEHHCCCCC
ECYDDFDWQIASEKEGDCYARYRVRVEEMRQSLSIIRQACKMIPGGPTENLEAQRMVTED
CCCCCCCCEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHC
KKSEIFGIDYQYVAKKVAPTFKIPNGELYTRLESGKGEIGVFIQGNNEVTPWRFKIRAAD
CCCCEECCCHHHHHHHHCCCEECCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEECC
LNNLQILPHILKGAKIADIMAILGSIDVIMGSVDR
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA