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The map label for this gene is iscS [H]

Identifier: 123967725

GI number: 123967725

Start: 173705

End: 174850

Strand: Direct

Name: iscS [H]

Synonym: A9601_01881

Alternate gene names: 123967725

Gene position: 173705-174850 (Clockwise)

Preceding gene: 123967723

Following gene: 123967727

Centisome position: 10.4

GC content: 30.89

Gene sequence:

>1146_bases
ATGCTATCAACTCCCATACTACTAGACTATCAATCTTCGACTCCTTGCTCTAAAGATGTTGTTGATTCTATGAAACCTTT
TTGGAGTGAGATATTTTCTAATCCTGCAAGCAAATCTAATTTGGCGGGAATTAACGCAAGCGCTATATTGGAAGCCTCAA
GAGAAAAAATAGAACAAAATTTATTTCTTAAGAATAAAAAAGTTATTTTTACAAGCGGGGCAACTGAATCTAATAACTTA
GCTTTATTAGGTTTTGCTAGAAATTTCTATAAAAAAACAGGAAATTATGGACATATTATTACCTTAAAAACGGAGCATAA
AGCTGTTTTGGAGCCCCTAAATCAACTAAAAAAAGAGGGATTTATGGTTACAGAAATTAATCCTGATAAAGATGGCTTAA
TTTCAGAAGAACAATTCAAAAAAAATATAAAAGAAGATACATTTCTGGTTAGTGTAATGTTGGCAAATAACGAAATAGGA
GTTATTCAGCCCATAGAGAATATTTCAAAGATATGTAAATCGAGAGGAATAATTTTCCACTCTGATTTTGCACAATGTTT
AGGTTATATGGCGTTAGACAATCTTTTATCAGATGTAAACATGATAACGATGAGTTCGCACAAAATATATGGTCCAAAAG
GGATAGGACTTCTTTTGATTGATGAAGAAATTAATCTTGAGCCTTTAATTGTTGGAGGAGGTCAGGAATATGGTCTTAGG
TCTGGAACATTACCTCTTCCTTTAGTAGTTGGCTTTGCTAAAGCAATAGAGATAGCAGTTTTTAATCAAAAAAATAATGC
TGAGAAATTACTTTTTTACAGAAATAACCTTTTAGAGGGGTTGTTAAAAAATAATTCTGGTTTATTAATTAATGGCTCTA
TAGAAAAAAGATTACCTCACAATTTAAATTTGACTGTATTGGATTTAAACGGAGCAAAGTTTCATAAACTTTTAAAATCT
AAAATAATTTGTTCTACTGGATCTGCATGTAGTAGTGGTGAACCATCTCATGTTTTACTAGCCTTAGGTAGATCTCTTAA
AGAAGTAGAATCTTCAATAAGGCTAAGTATTGGATTAAGTACTAATTCAAAAGATATAAAACAAGCAATTCATATTCTTA
CAAATACGATCAGATCATTACGATAG

Upstream 100 bases:

>100_bases
TTTCTTACAAGTTCATTATTTATTTGATTAATTTCATTCATTTTTTAAATTCTTAAATTTGATTTTCTAGTAATAAACAG
AATTTTATATACTTAACATA

Downstream 100 bases:

>100_bases
GAAAATATTTGCTTTTAATTTAATTGAGCAATTCTTAATTTTCCACTTCTAGCTCTTTTATTTAGTTCAATTTCTTGTTC
GGAAGGAGTTATTGGCTTTT

Product: NifS-like aminotransferase class-V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MLSTPILLDYQSSTPCSKDVVDSMKPFWSEIFSNPASKSNLAGINASAILEASREKIEQNLFLKNKKVIFTSGATESNNL
ALLGFARNFYKKTGNYGHIITLKTEHKAVLEPLNQLKKEGFMVTEINPDKDGLISEEQFKKNIKEDTFLVSVMLANNEIG
VIQPIENISKICKSRGIIFHSDFAQCLGYMALDNLLSDVNMITMSSHKIYGPKGIGLLLIDEEINLEPLIVGGGQEYGLR
SGTLPLPLVVGFAKAIEIAVFNQKNNAEKLLFYRNNLLEGLLKNNSGLLINGSIEKRLPHNLNLTVLDLNGAKFHKLLKS
KIICSTGSACSSGEPSHVLLALGRSLKEVESSIRLSIGLSTNSKDIKQAIHILTNTIRSLR

Sequences:

>Translated_381_residues
MLSTPILLDYQSSTPCSKDVVDSMKPFWSEIFSNPASKSNLAGINASAILEASREKIEQNLFLKNKKVIFTSGATESNNL
ALLGFARNFYKKTGNYGHIITLKTEHKAVLEPLNQLKKEGFMVTEINPDKDGLISEEQFKKNIKEDTFLVSVMLANNEIG
VIQPIENISKICKSRGIIFHSDFAQCLGYMALDNLLSDVNMITMSSHKIYGPKGIGLLLIDEEINLEPLIVGGGQEYGLR
SGTLPLPLVVGFAKAIEIAVFNQKNNAEKLLFYRNNLLEGLLKNNSGLLINGSIEKRLPHNLNLTVLDLNGAKFHKLLKS
KIICSTGSACSSGEPSHVLLALGRSLKEVESSIRLSIGLSTNSKDIKQAIHILTNTIRSLR
>Mature_381_residues
MLSTPILLDYQSSTPCSKDVVDSMKPFWSEIFSNPASKSNLAGINASAILEASREKIEQNLFLKNKKVIFTSGATESNNL
ALLGFARNFYKKTGNYGHIITLKTEHKAVLEPLNQLKKEGFMVTEINPDKDGLISEEQFKKNIKEDTFLVSVMLANNEIG
VIQPIENISKICKSRGIIFHSDFAQCLGYMALDNLLSDVNMITMSSHKIYGPKGIGLLLIDEEINLEPLIVGGGQEYGLR
SGTLPLPLVVGFAKAIEIAVFNQKNNAEKLLFYRNNLLEGLLKNNSGLLINGSIEKRLPHNLNLTVLDLNGAKFHKLLKS
KIICSTGSACSSGEPSHVLLALGRSLKEVESSIRLSIGLSTNSKDIKQAIHILTNTIRSLR

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=381, Percent_Identity=38.0577427821522, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI156713448, Length=415, Percent_Identity=30.3614457831325, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=40.6735751295337, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1787970, Length=388, Percent_Identity=22.4226804123711, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789175, Length=301, Percent_Identity=24.5847176079734, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=386, Percent_Identity=40.1554404145078, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17533177, Length=316, Percent_Identity=33.5443037974684, Blast_Score=153, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319831, Length=383, Percent_Identity=41.5143603133159, Blast_Score=280, Evalue=3e-76,
Organism=Drosophila melanogaster, GI20129463, Length=381, Percent_Identity=38.5826771653543, Blast_Score=264, Evalue=9e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41898; Mature: 41898

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSTPILLDYQSSTPCSKDVVDSMKPFWSEIFSNPASKSNLAGINASAILEASREKIEQN
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LFLKNKKVIFTSGATESNNLALLGFARNFYKKTGNYGHIITLKTEHKAVLEPLNQLKKEG
HEECCCEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC
FMVTEINPDKDGLISEEQFKKNIKEDTFLVSVMLANNEIGVIQPIENISKICKSRGIIFH
EEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHCCCEEE
SDFAQCLGYMALDNLLSDVNMITMSSHKIYGPKGIGLLLIDEEINLEPLIVGGGQEYGLR
CCHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCCEEEEEECCCCCCEEEEECCCCCCCC
SGTLPLPLVVGFAKAIEIAVFNQKNNAEKLLFYRNNLLEGLLKNNSGLLINGSIEKRLPH
CCCCCHHHHHHHHHHEEEEEECCCCCCHHEEEHHHHHHHHHHCCCCCEEEECCHHHCCCC
NLNLTVLDLNGAKFHKLLKSKIICSTGSACSSGEPSHVLLALGRSLKEVESSIRLSIGLS
CCCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEC
TNSKDIKQAIHILTNTIRSLR
CCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSTPILLDYQSSTPCSKDVVDSMKPFWSEIFSNPASKSNLAGINASAILEASREKIEQN
CCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LFLKNKKVIFTSGATESNNLALLGFARNFYKKTGNYGHIITLKTEHKAVLEPLNQLKKEG
HEECCCEEEEECCCCCCCCEEEEEEHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC
FMVTEINPDKDGLISEEQFKKNIKEDTFLVSVMLANNEIGVIQPIENISKICKSRGIIFH
EEEEEECCCCCCCCCHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHCCCEEE
SDFAQCLGYMALDNLLSDVNMITMSSHKIYGPKGIGLLLIDEEINLEPLIVGGGQEYGLR
CCHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCCEEEEEECCCCCCEEEEECCCCCCCC
SGTLPLPLVVGFAKAIEIAVFNQKNNAEKLLFYRNNLLEGLLKNNSGLLINGSIEKRLPH
CCCCCHHHHHHHHHHEEEEEECCCCCCHHEEEHHHHHHHHHHCCCCCEEEECCHHHCCCC
NLNLTVLDLNGAKFHKLLKSKIICSTGSACSSGEPSHVLLALGRSLKEVESSIRLSIGLS
CCCEEEEECCCHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEEEC
TNSKDIKQAIHILTNTIRSLR
CCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA