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The map label for this gene is glmU

Identifier: 121999206

GI number: 121999206

Start: 2668188

End: 2669609

Strand: Reverse

Name: glmU

Synonym: Hhal_2428

Alternate gene names: 121999206

Gene position: 2669609-2668188 (Counterclockwise)

Preceding gene: 121999207

Following gene: 121999205

Centisome position: 99.67

GC content: 70.6

Gene sequence:

>1422_bases
ATGCGGGCACCTGTTGCCGTGGTCATACTGGCTGCGGGCAAAGGGACCCGCATGCGCTCGGCCCAGCCTAAGGTTCTGCA
ACCGCTGGCTGGGCGCCCCCTGCTTGCCCACGTCCTGGATACGGCCCTGGCCCTGGGGCCGGAGCAGGTTCACGTGGTCT
ACGGCCACGGCGGCGATCAGGTCGCCGCCGCGCACGCCGATTACCCGGTCTACTGGGTTGAACAGCCCCGCCAACTCGGG
ACCGGGCACGCGGTGGCGTGCGCGCTGCCGCAGATCCCGGACGATCACCGGGTGCTGGTCCTCTATGGTGACGTCCCCCT
GGTCACCCCTGAGACCCTCAAACCCCTGCTTGCCGGAGATGGACTGGAACTCCTGGCAGCCCGGGTCCCGGACCCGACCG
GTTACGGCCGCATCATCCGTGATGACGACGGCGCCGTGGTGGCCATCGTCGAGGAAAAGGACGCCGACCCGGAGCAGCGT
CGCGTCGATGAGGTCAACACCGGCCTTCTGGCCGCATCGGCCGGTGATCTGCGTCGCTGGATGGCCGCTCTGTCCGCCGA
CAACGCCCAGGGCGAGTACTACCTGACCGATGCGGTGGCGGCGGCGAGGGCGGACGGCACCCCGGTGCGTGCCCGGTTCA
CGAGCGAGGCCGGCGAAGCCAGCGGCATCAACGACCTGGTCCAGCTCGCGGAGGTGGAAGAGGCGTTCCAGCGACGCTGG
GCGCGGCGCCTGCTGCAGGGAGGGCTGCGCCTGGTAGCGCCGCACCGGTTCACCCTGCGTGGTGCGGTCCGCCACGGTAC
CGACTGCGCTGTGGACGCTGACTGCACCCTGGAGGGCGAAGTGCAGCTGGGCCATGGGGTGCAGGTCGGCCAAGGGGTGA
TCCTGCGCGACTGCGTGATCGAGGACGGGGCCCAAGTCGGCCCCTATACTGTGGTCGAGCAAGCCCACATTGGCGCAGGG
TGCCGCGTCGGCCCCTTCGCCCATCTGCGTCCAGGGACCGTGCTCGAGGAGGGCGCCCGGGTGGGAAATTTCGTCGAGAC
CAAGGCAGCCCGCCTGGGCCCTGGCGCAAAGGCCAACCACCTGACCTACGTCGGAGACGCCGAGGTCGGGGCCCGGGCCA
ACCTGGGGGCCGGCACCATCACCTGCAACTACGACGGGGCCGAGAAGCACCGTACGCAGATTGGTGAGGATGCCTTCATC
GGCTCCGGGAGCCAGCTGGTCGCGCCGGTCCAGGTGGGGGCGCGGGCGACCATCGGCGCCGGGACCACCCTGACCAGCGA
TGCGCCGGCCGACGCCCTCACCGTGGGCCGCAGCCGCGCCCGGACCATCCCCGGCTGGCAGCACCCCGGCTTGACGGGCC
GTCGCGGACCTCCCGATGATAACGATGCGACGCCGGCGTCCGGCGGTGCCAAGGAAGAGTAA

Upstream 100 bases:

>100_bases
GCTCGGTCCAGGCGGAGCTTGCCGAGGCCATGGCGCAGCTGCGAACCCTGGAGAGCCTGCGCAAGCGGGCCAAGCGCTGA
CCCGAACGGAGGAACCGACC

Downstream 100 bases:

>100_bases
GGAGCGAGCATGTTCGACCACACAGTCGTTGCGGTGCACTTCGAGTCCCCTTACCAGCCGCTGCTCGATGCCGTCAGCGA
GCTGCACAAGTTTGGGGCGA

Product: UDP-N-acetylglucosamine pyrophosphorylase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRAPVAVVILAAGKGTRMRSAQPKVLQPLAGRPLLAHVLDTALALGPEQVHVVYGHGGDQVAAAHADYPVYWVEQPRQLG
TGHAVACALPQIPDDHRVLVLYGDVPLVTPETLKPLLAGDGLELLAARVPDPTGYGRIIRDDDGAVVAIVEEKDADPEQR
RVDEVNTGLLAASAGDLRRWMAALSADNAQGEYYLTDAVAAARADGTPVRARFTSEAGEASGINDLVQLAEVEEAFQRRW
ARRLLQGGLRLVAPHRFTLRGAVRHGTDCAVDADCTLEGEVQLGHGVQVGQGVILRDCVIEDGAQVGPYTVVEQAHIGAG
CRVGPFAHLRPGTVLEEGARVGNFVETKAARLGPGAKANHLTYVGDAEVGARANLGAGTITCNYDGAEKHRTQIGEDAFI
GSGSQLVAPVQVGARATIGAGTTLTSDAPADALTVGRSRARTIPGWQHPGLTGRRGPPDDNDATPASGGAKEE

Sequences:

>Translated_473_residues
MRAPVAVVILAAGKGTRMRSAQPKVLQPLAGRPLLAHVLDTALALGPEQVHVVYGHGGDQVAAAHADYPVYWVEQPRQLG
TGHAVACALPQIPDDHRVLVLYGDVPLVTPETLKPLLAGDGLELLAARVPDPTGYGRIIRDDDGAVVAIVEEKDADPEQR
RVDEVNTGLLAASAGDLRRWMAALSADNAQGEYYLTDAVAAARADGTPVRARFTSEAGEASGINDLVQLAEVEEAFQRRW
ARRLLQGGLRLVAPHRFTLRGAVRHGTDCAVDADCTLEGEVQLGHGVQVGQGVILRDCVIEDGAQVGPYTVVEQAHIGAG
CRVGPFAHLRPGTVLEEGARVGNFVETKAARLGPGAKANHLTYVGDAEVGARANLGAGTITCNYDGAEKHRTQIGEDAFI
GSGSQLVAPVQVGARATIGAGTTLTSDAPADALTVGRSRARTIPGWQHPGLTGRRGPPDDNDATPASGGAKEE
>Mature_473_residues
MRAPVAVVILAAGKGTRMRSAQPKVLQPLAGRPLLAHVLDTALALGPEQVHVVYGHGGDQVAAAHADYPVYWVEQPRQLG
TGHAVACALPQIPDDHRVLVLYGDVPLVTPETLKPLLAGDGLELLAARVPDPTGYGRIIRDDDGAVVAIVEEKDADPEQR
RVDEVNTGLLAASAGDLRRWMAALSADNAQGEYYLTDAVAAARADGTPVRARFTSEAGEASGINDLVQLAEVEEAFQRRW
ARRLLQGGLRLVAPHRFTLRGAVRHGTDCAVDADCTLEGEVQLGHGVQVGQGVILRDCVIEDGAQVGPYTVVEQAHIGAG
CRVGPFAHLRPGTVLEEGARVGNFVETKAARLGPGAKANHLTYVGDAEVGARANLGAGTITCNYDGAEKHRTQIGEDAFI
GSGSQLVAPVQVGARATIGAGTTLTSDAPADALTVGRSRARTIPGWQHPGLTGRRGPPDDNDATPASGGAKEE

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=452, Percent_Identity=51.1061946902655, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_HALHL (A1WZS9)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003993.1
- ProteinModelPortal:   A1WZS9
- SMR:   A1WZS9
- STRING:   A1WZS9
- GeneID:   4710798
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2428
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   A1WZS9
- ProtClustDB:   CLSK727745
- BioCyc:   HHAL349124:HHAL_2428-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49473; Mature: 49473

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 360-360 BINDING 75-75 BINDING 136-136 BINDING 151-151 BINDING 166-166 BINDING 384-384 BINDING 402-402 BINDING 420-420 BINDING 437-437

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPVAVVILAAGKGTRMRSAQPKVLQPLAGRPLLAHVLDTALALGPEQVHVVYGHGGDQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCE
VAAAHADYPVYWVEQPRQLGTGHAVACALPQIPDDHRVLVLYGDVPLVTPETLKPLLAGD
EEEECCCCCEEEECCCHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
GLELLAARVPDPTGYGRIIRDDDGAVVAIVEEKDADPEQRRVDEVNTGLLAASAGDLRRW
CHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHH
MAALSADNAQGEYYLTDAVAAARADGTPVRARFTSEAGEASGINDLVQLAEVEEAFQRRW
HHHHCCCCCCCCEEEEHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
ARRLLQGGLRLVAPHRFTLRGAVRHGTDCAVDADCTLEGEVQLGHGVQVGQGVILRDCVI
HHHHHHCCCEEECCCEEEEEEHHHCCCCCEECCCCEEECCEEECCCEECCCCEEEEEHHH
EDGAQVGPYTVVEQAHIGAGCRVGPFAHLRPGTVLEEGARVGNFVETKAARLGPGAKANH
CCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCC
LTYVGDAEVGARANLGAGTITCNYDGAEKHRTQIGEDAFIGSGSQLVAPVQVGARATIGA
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCEECCCCCEEEEEECCCEEEECC
GTTLTSDAPADALTVGRSRARTIPGWQHPGLTGRRGPPDDNDATPASGGAKEE
CCEECCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRAPVAVVILAAGKGTRMRSAQPKVLQPLAGRPLLAHVLDTALALGPEQVHVVYGHGGDQ
CCCCEEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCE
VAAAHADYPVYWVEQPRQLGTGHAVACALPQIPDDHRVLVLYGDVPLVTPETLKPLLAGD
EEEECCCCCEEEECCCHHCCCCCEEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCC
GLELLAARVPDPTGYGRIIRDDDGAVVAIVEEKDADPEQRRVDEVNTGLLAASAGDLRRW
CHHHHHHHCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHCCCEEEECHHHHHHH
MAALSADNAQGEYYLTDAVAAARADGTPVRARFTSEAGEASGINDLVQLAEVEEAFQRRW
HHHHCCCCCCCCEEEEHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHH
ARRLLQGGLRLVAPHRFTLRGAVRHGTDCAVDADCTLEGEVQLGHGVQVGQGVILRDCVI
HHHHHHCCCEEECCCEEEEEEHHHCCCCCEECCCCEEECCEEECCCEECCCCEEEEEHHH
EDGAQVGPYTVVEQAHIGAGCRVGPFAHLRPGTVLEEGARVGNFVETKAARLGPGAKANH
CCCCCCCCEEEEEHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCC
LTYVGDAEVGARANLGAGTITCNYDGAEKHRTQIGEDAFIGSGSQLVAPVQVGARATIGA
EEEECCCCCCCCCCCCCCEEEECCCCCHHHHHHCCCCCEECCCCCEEEEEECCCEEEECC
GTTLTSDAPADALTVGRSRARTIPGWQHPGLTGRRGPPDDNDATPASGGAKEE
CCEECCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA