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The map label for this gene is betT [H]

Identifier: 121999142

GI number: 121999142

Start: 2594084

End: 2596141

Strand: Reverse

Name: betT [H]

Synonym: Hhal_2364

Alternate gene names: 121999142

Gene position: 2596141-2594084 (Counterclockwise)

Preceding gene: 121999143

Following gene: 121999133

Centisome position: 96.93

GC content: 66.13

Gene sequence:

>2058_bases
ATGATCGATCGCAAGCGCGCCTTCCGCACCACCATCCTCGCCCCGGTCTTCTTCCCCGCCATCGCTGTTGCGCTGCTGCT
GATCATCGGGGCGATCAGCAGCCCGGACCTGGCCGGGGCGTTCTTCGAGGACTTGCTCGCCTTCATCACCGAGACCTTCG
GCTGGTTCTACATGCTGGCGGTGGCGGCGTTCCTGGTCTTTCTGGTGGCGGTTGCCTTCACCCGGTGGGGCCATATCAAG
CTCGGGCCGGAGCACGGCGAGCCGCAGTACAGCTTCCCCGCGTGGTTCGCCATGCTCTTCTCGGCGGGCTACGGGATCGT
GCTGCTCTTCTTCGGCGTGGCCGAGCCGGTGCTCCACTACGCCGATCCGCCCCGGGGTGAGCCGGAGACGATTGAGGCGG
CGCGCCAGGCGATGCAGATCGCCTTCTTCCACTGGGGCTTCCACATCTGGGCCATCTACGGCCTGGTGGGGTTGGTGCTG
GCGTACTTCTCGTTCCGCCACGGCCTGCCGCTGTCGATCCGTTCGGCGCTCTACCCGCTGATCGGCGATCGCATCTACGG
GCCCATCGGCCATACGGTGGATGTCTTCGCCATCCTCGGCACGCTGTTCGGCATCGCCACCACGCTGGGGCTGTCGGTGG
CGCAGATCAACGCCGGGCTCAACTACCTGTGGCCGTCGATCCCCACCAGCACCACGGTGCAGGTCATCGTCATCGCGGTG
ATTACGGCGCTGGCGACCATCTCCGTGGTCGCCGGCCTGGACAAGGGCATCAAGCGGCTGTCGATCCTCAACATGATCCT
CGCCGCAGCGCTGATGCTCTTCGTCTTCCTGGTCGGCCCGTCGATCCTGATCGTGGAGACCTTCCTGCAGAACACCGGCA
GCTACGTCAGCGGCATCGTCGAGCGCACCTTCAATCTCGAGGCCTACGAGCGGCGGGAGTGGATCGGCAACTGGACGCTG
TTCATCTTCGGCTGGACCATCGCCTGGGCGCCGTTCGTGGGCATGTTCATCGCCAAGATCAGCCGCGGGCGGACCATCCG
CCAGTTCGTCGTCGGCGTGATGCTGGTGCCGACGCTCTTCACCTTCCTGTGGTTCTCGATCTTCGGCGGCACCGGCCTGA
ACCTGATCATGAACGAGGGCTACGAGCAGCTCATCGGCCTTGTGCAGGAGGACGAGGCGGTGGCCCTGTTCCAGCTCTAC
GACATCCTGCCGTGGAGTGCCCTGGCGTCGTTCGTCACCGTGATCCTGATCATGACCTTCTTCGTCACCTCGTCGGACTC
CGGCTCGCTGGTCATCGATCAGCTCGCCTCCGGCGGCGCGTCGGTGACGCCGGTCTGGCAGCGGGTCTTCTGGGCGGTGC
TCGAGGGCGCGGTGGCGGCGGTGCTGCTCATCGCCGGCGGATTGGCGGCGCTGCAGACCATGGCGGTGACCAGTGCCCTG
CCGTTCGCGGTGATCATGCTCATCGCTGCCGGTGGGCTATGGCGGGCCCTGATCATCGAGAGCCACCACGACACCAGCCT
GCAGAATCACGTCCAGCGCCGCCAGCGCTACGGTACGCTGCTGTGGAAGAAGCGGCTCTACGAGCTGTTCGACTTCCCCA
CCCGCGACGACGTGATGGCATTCATCCGCGGCCCGGTGGTGCAGGCCCTGGAGCACGTTCAGAAGGCCCTCGACCAGCGC
GGCTGGCCGGCCAAAGTGGTGCTCGATGAGGATCACGGACGGGTCTACCTAGCGGTACACCGCGACGGGTTGATGGACTT
CCTCTACGACGTGCGCCTGACCGAGCGCCCGCGTCCGGCCTTCGCCTACCCGTCCATCGATCCCTCGGGCGGACCGGCTG
AGGTCTACTACCGCCCGGAGGTCTACCTGCGCCGGGGCGGGCAGTCGTACAGCGTCTACGAGTACAACGAGCAGGAGATC
ATCGACGACGTCCTCGATCACTTCGAGAGCTATCTGCAGTTCCTCGACTCGGCGCCGGCCACGCTGCCGTGGGCGACGGA
GGCGCACGACGAGATGATCGACGCCCCGGTGGGTGGCAAGGGCCGCGGACGGGGGTGA

Upstream 100 bases:

>100_bases
TGGGCCTAATCTGCCTAAAGAGCCGGTCTGGCTGCCGCCCCCGAGCAGCATGCGTGGGCCCGCGTCGGACGGCTGACCCC
GGCCACCAAGAGCAGGGCCC

Downstream 100 bases:

>100_bases
TCAGGCCGCCGGCTCGCCCGAGCGTTGGCCGAGCACGCCGGCGTAAAGGGCCAGCGTCTCCCGCGCCGTGCGCTCGACGG
TCAAGCGGGTGGCGATGCGC

Product: choline/carnitine/betaine transporter

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 685; Mature: 685

Protein sequence:

>685_residues
MIDRKRAFRTTILAPVFFPAIAVALLLIIGAISSPDLAGAFFEDLLAFITETFGWFYMLAVAAFLVFLVAVAFTRWGHIK
LGPEHGEPQYSFPAWFAMLFSAGYGIVLLFFGVAEPVLHYADPPRGEPETIEAARQAMQIAFFHWGFHIWAIYGLVGLVL
AYFSFRHGLPLSIRSALYPLIGDRIYGPIGHTVDVFAILGTLFGIATTLGLSVAQINAGLNYLWPSIPTSTTVQVIVIAV
ITALATISVVAGLDKGIKRLSILNMILAAALMLFVFLVGPSILIVETFLQNTGSYVSGIVERTFNLEAYERREWIGNWTL
FIFGWTIAWAPFVGMFIAKISRGRTIRQFVVGVMLVPTLFTFLWFSIFGGTGLNLIMNEGYEQLIGLVQEDEAVALFQLY
DILPWSALASFVTVILIMTFFVTSSDSGSLVIDQLASGGASVTPVWQRVFWAVLEGAVAAVLLIAGGLAALQTMAVTSAL
PFAVIMLIAAGGLWRALIIESHHDTSLQNHVQRRQRYGTLLWKKRLYELFDFPTRDDVMAFIRGPVVQALEHVQKALDQR
GWPAKVVLDEDHGRVYLAVHRDGLMDFLYDVRLTERPRPAFAYPSIDPSGGPAEVYYRPEVYLRRGGQSYSVYEYNEQEI
IDDVLDHFESYLQFLDSAPATLPWATEAHDEMIDAPVGGKGRGRG

Sequences:

>Translated_685_residues
MIDRKRAFRTTILAPVFFPAIAVALLLIIGAISSPDLAGAFFEDLLAFITETFGWFYMLAVAAFLVFLVAVAFTRWGHIK
LGPEHGEPQYSFPAWFAMLFSAGYGIVLLFFGVAEPVLHYADPPRGEPETIEAARQAMQIAFFHWGFHIWAIYGLVGLVL
AYFSFRHGLPLSIRSALYPLIGDRIYGPIGHTVDVFAILGTLFGIATTLGLSVAQINAGLNYLWPSIPTSTTVQVIVIAV
ITALATISVVAGLDKGIKRLSILNMILAAALMLFVFLVGPSILIVETFLQNTGSYVSGIVERTFNLEAYERREWIGNWTL
FIFGWTIAWAPFVGMFIAKISRGRTIRQFVVGVMLVPTLFTFLWFSIFGGTGLNLIMNEGYEQLIGLVQEDEAVALFQLY
DILPWSALASFVTVILIMTFFVTSSDSGSLVIDQLASGGASVTPVWQRVFWAVLEGAVAAVLLIAGGLAALQTMAVTSAL
PFAVIMLIAAGGLWRALIIESHHDTSLQNHVQRRQRYGTLLWKKRLYELFDFPTRDDVMAFIRGPVVQALEHVQKALDQR
GWPAKVVLDEDHGRVYLAVHRDGLMDFLYDVRLTERPRPAFAYPSIDPSGGPAEVYYRPEVYLRRGGQSYSVYEYNEQEI
IDDVLDHFESYLQFLDSAPATLPWATEAHDEMIDAPVGGKGRGRG
>Mature_685_residues
MIDRKRAFRTTILAPVFFPAIAVALLLIIGAISSPDLAGAFFEDLLAFITETFGWFYMLAVAAFLVFLVAVAFTRWGHIK
LGPEHGEPQYSFPAWFAMLFSAGYGIVLLFFGVAEPVLHYADPPRGEPETIEAARQAMQIAFFHWGFHIWAIYGLVGLVL
AYFSFRHGLPLSIRSALYPLIGDRIYGPIGHTVDVFAILGTLFGIATTLGLSVAQINAGLNYLWPSIPTSTTVQVIVIAV
ITALATISVVAGLDKGIKRLSILNMILAAALMLFVFLVGPSILIVETFLQNTGSYVSGIVERTFNLEAYERREWIGNWTL
FIFGWTIAWAPFVGMFIAKISRGRTIRQFVVGVMLVPTLFTFLWFSIFGGTGLNLIMNEGYEQLIGLVQEDEAVALFQLY
DILPWSALASFVTVILIMTFFVTSSDSGSLVIDQLASGGASVTPVWQRVFWAVLEGAVAAVLLIAGGLAALQTMAVTSAL
PFAVIMLIAAGGLWRALIIESHHDTSLQNHVQRRQRYGTLLWKKRLYELFDFPTRDDVMAFIRGPVVQALEHVQKALDQR
GWPAKVVLDEDHGRVYLAVHRDGLMDFLYDVRLTERPRPAFAYPSIDPSGGPAEVYYRPEVYLRRGGQSYSVYEYNEQEI
IDDVLDHFESYLQFLDSAPATLPWATEAHDEMIDAPVGGKGRGRG

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=671, Percent_Identity=39.4932935916543, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1786224, Length=489, Percent_Identity=26.5848670756646, Blast_Score=163, Evalue=3e-41,
Organism=Escherichia coli, GI1788102, Length=447, Percent_Identity=28.6353467561521, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 75935; Mature: 75935

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRKRAFRTTILAPVFFPAIAVALLLIIGAISSPDLAGAFFEDLLAFITETFGWFYMLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAAFLVFLVAVAFTRWGHIKLGPEHGEPQYSFPAWFAMLFSAGYGIVLLFFGVAEPVLHY
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
ADPPRGEPETIEAARQAMQIAFFHWGFHIWAIYGLVGLVLAYFSFRHGLPLSIRSALYPL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IGDRIYGPIGHTVDVFAILGTLFGIATTLGLSVAQINAGLNYLWPSIPTSTTVQVIVIAV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHH
ITALATISVVAGLDKGIKRLSILNMILAAALMLFVFLVGPSILIVETFLQNTGSYVSGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHH
ERTFNLEAYERREWIGNWTLFIFGWTIAWAPFVGMFIAKISRGRTIRQFVVGVMLVPTLF
HHHCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TFLWFSIFGGTGLNLIMNEGYEQLIGLVQEDEAVALFQLYDILPWSALASFVTVILIMTF
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FVTSSDSGSLVIDQLASGGASVTPVWQRVFWAVLEGAVAAVLLIAGGLAALQTMAVTSAL
HHCCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFAVIMLIAAGGLWRALIIESHHDTSLQNHVQRRQRYGTLLWKKRLYELFDFPTRDDVMA
HHHHHHHHHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FIRGPVVQALEHVQKALDQRGWPAKVVLDEDHGRVYLAVHRDGLMDFLYDVRLTERPRPA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCHHHHHHHHHHCCCCCCCC
FAYPSIDPSGGPAEVYYRPEVYLRRGGQSYSVYEYNEQEIIDDVLDHFESYLQFLDSAPA
CCCCCCCCCCCCCEEEECCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCC
TLPWATEAHDEMIDAPVGGKGRGRG
CCCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MIDRKRAFRTTILAPVFFPAIAVALLLIIGAISSPDLAGAFFEDLLAFITETFGWFYMLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VAAFLVFLVAVAFTRWGHIKLGPEHGEPQYSFPAWFAMLFSAGYGIVLLFFGVAEPVLHY
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
ADPPRGEPETIEAARQAMQIAFFHWGFHIWAIYGLVGLVLAYFSFRHGLPLSIRSALYPL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IGDRIYGPIGHTVDVFAILGTLFGIATTLGLSVAQINAGLNYLWPSIPTSTTVQVIVIAV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHH
ITALATISVVAGLDKGIKRLSILNMILAAALMLFVFLVGPSILIVETFLQNTGSYVSGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHH
ERTFNLEAYERREWIGNWTLFIFGWTIAWAPFVGMFIAKISRGRTIRQFVVGVMLVPTLF
HHHCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
TFLWFSIFGGTGLNLIMNEGYEQLIGLVQEDEAVALFQLYDILPWSALASFVTVILIMTF
HHHHHHHHCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FVTSSDSGSLVIDQLASGGASVTPVWQRVFWAVLEGAVAAVLLIAGGLAALQTMAVTSAL
HHCCCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFAVIMLIAAGGLWRALIIESHHDTSLQNHVQRRQRYGTLLWKKRLYELFDFPTRDDVMA
HHHHHHHHHCCCHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
FIRGPVVQALEHVQKALDQRGWPAKVVLDEDHGRVYLAVHRDGLMDFLYDVRLTERPRPA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCHHHHHHHHHHCCCCCCCC
FAYPSIDPSGGPAEVYYRPEVYLRRGGQSYSVYEYNEQEIIDDVLDHFESYLQFLDSAPA
CCCCCCCCCCCCCEEEECCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCC
TLPWATEAHDEMIDAPVGGKGRGRG
CCCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]