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The map label for this gene is mutM

Identifier: 121999089

GI number: 121999089

Start: 2537419

End: 2538231

Strand: Reverse

Name: mutM

Synonym: Hhal_2311

Alternate gene names: 121999089

Gene position: 2538231-2537419 (Counterclockwise)

Preceding gene: 121999090

Following gene: 121999083

Centisome position: 94.76

GC content: 71.96

Gene sequence:

>813_bases
TTGCCCGAGCTGCCCGAGGTTGAGACCACCCGTCGCGGCCTGCAGGTCCACCTGGTCGGGCGTACCCTGCAGCGCGTCGT
GGTACGCCAACGGCAGCTGCGCTATCCCGTGCCGGCCAGGGTGGAGGCCGCCGTCGTCGGTGAGGAGGTGGTGGCCCTGG
AGCGGCGCGCCAAGTATCTGCTGATCCGCCTTGGCGGCGGTGCCTGGCTGTTGCTGCATCTGGGTATGTCCGGGAGCCTG
CGGCTGGTGGCGGAGACCGATGCCCCGGGGCGGCACGACCATGTCGATCTGGTCCTCAATGATGGCCGTGCCGTCCGCCT
GACCGACCCGCGCCGTTTTGGCTGCCTGCTCCTCGGTGACGGGGACCCGCAGGACCACCGGCTGCTCCGCCGCCTTGGCC
CCGAGCCGTTGGGATCGGCCTTCGATGGGGCCGTGCTGCACCGCGCGGCCCGTGGCCGTCGCGTGGCGGTGAAGGCCCTG
CTGATGGATGCCACCGTCGTGGTCGGGGTGGGGAATATCTATGCCAATGAGGCGCTCTTTCGTGCCGGTATCCGCCCGGA
CCGAGCGGCCGGGCGGATCGCCCGGGCCCGGTACGACCGCCTGGCCGGGGCCGTACGGGCGGTCCTGGAGGCAGCGCTGG
CGGCGGGGGGCACCACGCTGCGCGATTTCACCGACGGTTCGGGTGAGCCGGGATACTTCGCCGTGAATCTGTCCGTCTAT
GGCGCTTCGGTGTGCCCGGTCTGCGGCGGCGCGCTGCGCCAGATCCGGCTGGCGCAGCGCGGGACCTGGTTCTGCCCCCG
GTGCCAGCGCTAG

Upstream 100 bases:

>100_bases
GGCCTGGCTAGCTCATCTATCCCGCAGCGAGCGTCCGGAACGGTTGGCCGCCCGCCGGCGTGGTCCGCCGTCGGAATCGT
GATCCCAGGGGAGGCGGCCG

Downstream 100 bases:

>100_bases
GCAGGCCTAGAGCGCGGGCGTACCGAGCCACAGGCCGAGGGCGAACAGGGTCATGAACAGCAGGATGATGAAGACATCCC
GCAGCATCCGGAATAGGTCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MPELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYLLIRLGGGAWLLLHLGMSGSL
RLVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGDGDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKAL
LMDATVVVGVGNIYANEALFRAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVY
GASVCPVCGGALRQIRLAQRGTWFCPRCQR

Sequences:

>Translated_270_residues
MPELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYLLIRLGGGAWLLLHLGMSGSL
RLVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGDGDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKAL
LMDATVVVGVGNIYANEALFRAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVY
GASVCPVCGGALRQIRLAQRGTWFCPRCQR
>Mature_269_residues
PELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYLLIRLGGGAWLLLHLGMSGSLR
LVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGDGDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKALL
MDATVVVGVGNIYANEALFRAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVYG
ASVCPVCGGALRQIRLAQRGTWFCPRCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=48.8970588235294, Blast_Score=263, Evalue=7e-72,
Organism=Escherichia coli, GI1786932, Length=282, Percent_Identity=22.3404255319149, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_HALHL (A1WZG2)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003876.1
- ProteinModelPortal:   A1WZG2
- SMR:   A1WZG2
- STRING:   A1WZG2
- GeneID:   4709387
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2311
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   A1WZG2
- BioCyc:   HHAL349124:HHAL_2311-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29314; Mature: 29183

Theoretical pI: Translated: 11.06; Mature: 11.06

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 260-260 BINDING 92-92 BINDING 111-111 BINDING 153-153

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYL
CCCCCCCHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEE
LIRLGGGAWLLLHLGMSGSLRLVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGD
EEEECCCEEEEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEEEEEEC
GDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKALLMDATVVVGVGNIYANEALF
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCHHHHHHHH
RAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVY
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEE
GASVCPVCGGALRQIRLAQRGTWFCPRCQR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTRRGLQVHLVGRTLQRVVVRQRQLRYPVPARVEAAVVGEEVVALERRAKYL
CCCCCCHHHHCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEE
LIRLGGGAWLLLHLGMSGSLRLVAETDAPGRHDHVDLVLNDGRAVRLTDPRRFGCLLLGD
EEEECCCEEEEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCEEEEECCCCEEEEEEEC
GDPQDHRLLRRLGPEPLGSAFDGAVLHRAARGRRVAVKALLMDATVVVGVGNIYANEALF
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCEEEEECCCHHHHHHHH
RAGIRPDRAAGRIARARYDRLAGAVRAVLEAALAAGGTTLRDFTDGSGEPGYFAVNLSVY
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEE
GASVCPVCGGALRQIRLAQRGTWFCPRCQR
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA