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The map label for this gene is ddl

Identifier: 121998867

GI number: 121998867

Start: 2291938

End: 2292852

Strand: Reverse

Name: ddl

Synonym: Hhal_2088

Alternate gene names: 121998867

Gene position: 2292852-2291938 (Counterclockwise)

Preceding gene: 121998868

Following gene: 121998866

Centisome position: 85.6

GC content: 70.6

Gene sequence:

>915_bases
GTGAGTGGTATCCCGGATCCGCAGCGGGTGGGGCGCGTCGCCGTGCTGATGGGCGGCACCTCGGCCGAGCGGGACATCTC
CCTGCGCAGTGGCGGCGCGATACTCGCGGCGCTACAGCGCTGTGGCTACGACGCCGAGGCCTACGATCCCCGTGACCGCG
CCCTGGAAGGGCTGCGCGGCTACGACGTGGTCTTCATCGCCCTTCACGGGCGGGGCGGTGAGGACGGCACGGTCCAGGGA
CTGCTGGATCTGCTCGGAATCCCGTACACCGGCAGCGGTGTCCTCGGCTCGGCGCTGGGCATGGACAAGTGGCGCTGCAA
GCGGCTCTGGCAGGGCAGTGGCCTGCCCACGCCGGCGGGTCAGTTGCTGACCGGCGACCGCCCGGTCCTCGACGAGGGGG
TGGGTTACCCAGTGATCGTCAAGCCCGCCCGCGAGGGGTCGAGCCTCGGCATGAGTCGGGTCGAGGGGCCGGAGGAGCTG
GCCGAGGCCTACCGCGTGGCAGCGGCCTACGACGATACCGTCCTCGCCGAGGCCTGGGTCGAGGGCGAGGAGTACACCGT
GGCGCTGCTCGGTGATCAGGCGTTGCCGTCGATCCGACTGGAGACCCCGCACGCCTTCTTCGACTACGCGGCCAAGTACC
AGGCCGAGGACACCGGTCACCACTGCCCGAGCGGTCTCGGGCCGGAGGAAGAGGCCGAACTTGGCGCCCTGTGTCGGGAG
GCCTTTATCGCCAGCGGCGGGAACGGCTGGGGGCGTGTGGATGTCATGCGGGACACCGGCGGACGCTGGTGGCTGCTGGA
GGTGAATACCATCCCCGGCATGACCGATCACTCGCTGGTGCCCATCGCGGCGGCGCAGGCCGGGATCGGCTTCGACGAGC
TGGTGGCCCGCATCCTGGGGGAGGCGTTGCGATGA

Upstream 100 bases:

>100_bases
CGGATATCGAGGGGCTCATCGAGGTGGTCCGGCAGCGGGTTGCCGAGGTGCACGGTGTGCGGCTAGAGACCGAAGTCCAC
GTGATCGGGGGGGAGCAGTC

Downstream 100 bases:

>100_bases
GCCGTGAGGATTGGAGTGACCTGCTGGGCCGCCGCTCCTCCCGGCGCCCGCAGGGGCGCGCCGCTTTGCTGCCGGCGATG
CCGGGGCTGCGGGGCTGGCT

Product: D-alanine--D-alanine ligase

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSGIPDPQRVGRVAVLMGGTSAERDISLRSGGAILAALQRCGYDAEAYDPRDRALEGLRGYDVVFIALHGRGGEDGTVQG
LLDLLGIPYTGSGVLGSALGMDKWRCKRLWQGSGLPTPAGQLLTGDRPVLDEGVGYPVIVKPAREGSSLGMSRVEGPEEL
AEAYRVAAAYDDTVLAEAWVEGEEYTVALLGDQALPSIRLETPHAFFDYAAKYQAEDTGHHCPSGLGPEEEAELGALCRE
AFIASGGNGWGRVDVMRDTGGRWWLLEVNTIPGMTDHSLVPIAAAQAGIGFDELVARILGEALR

Sequences:

>Translated_304_residues
MSGIPDPQRVGRVAVLMGGTSAERDISLRSGGAILAALQRCGYDAEAYDPRDRALEGLRGYDVVFIALHGRGGEDGTVQG
LLDLLGIPYTGSGVLGSALGMDKWRCKRLWQGSGLPTPAGQLLTGDRPVLDEGVGYPVIVKPAREGSSLGMSRVEGPEEL
AEAYRVAAAYDDTVLAEAWVEGEEYTVALLGDQALPSIRLETPHAFFDYAAKYQAEDTGHHCPSGLGPEEEAELGALCRE
AFIASGGNGWGRVDVMRDTGGRWWLLEVNTIPGMTDHSLVPIAAAQAGIGFDELVARILGEALR
>Mature_303_residues
SGIPDPQRVGRVAVLMGGTSAERDISLRSGGAILAALQRCGYDAEAYDPRDRALEGLRGYDVVFIALHGRGGEDGTVQGL
LDLLGIPYTGSGVLGSALGMDKWRCKRLWQGSGLPTPAGQLLTGDRPVLDEGVGYPVIVKPAREGSSLGMSRVEGPEELA
EAYRVAAAYDDTVLAEAWVEGEEYTVALLGDQALPSIRLETPHAFFDYAAKYQAEDTGHHCPSGLGPEEEAELGALCREA
FIASGGNGWGRVDVMRDTGGRWWLLEVNTIPGMTDHSLVPIAAAQAGIGFDELVARILGEALR

Specific function: Cell wall formation

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Escherichia coli, GI1786280, Length=299, Percent_Identity=52.8428093645485, Blast_Score=310, Evalue=9e-86,
Organism=Escherichia coli, GI1786579, Length=347, Percent_Identity=30.5475504322767, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DDL_HALHL (A1WYU0)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003654.1
- ProteinModelPortal:   A1WYU0
- SMR:   A1WYU0
- STRING:   A1WYU0
- GeneID:   4710084
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2088
- eggNOG:   COG1181
- HOGENOM:   HBG427092
- OMA:   VPYTGSD
- PhylomeDB:   A1WYU0
- ProtClustDB:   PRK01372
- BioCyc:   HHAL349124:HHAL_2088-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00047
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR01205

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; SSF52440 PreATP-grasp-like

EC number: =6.3.2.4

Molecular weight: Translated: 32263; Mature: 32132

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIPDPQRVGRVAVLMGGTSAERDISLRSGGAILAALQRCGYDAEAYDPRDRALEGLRG
CCCCCCHHHHCEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCC
YDVVFIALHGRGGEDGTVQGLLDLLGIPYTGSGVLGSALGMDKWRCKRLWQGSGLPTPAG
CEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCC
QLLTGDRPVLDEGVGYPVIVKPAREGSSLGMSRVEGPEELAEAYRVAAAYDDTVLAEAWV
CEECCCCCCHHCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHC
EGEEYTVALLGDQALPSIRLETPHAFFDYAAKYQAEDTGHHCPSGLGPEEEAELGALCRE
CCCCEEEEEECCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AFIASGGNGWGRVDVMRDTGGRWWLLEVNTIPGMTDHSLVPIAAAQAGIGFDELVARILG
HHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEHHHHHCCCHHHHHHHHHH
EALR
HHCC
>Mature Secondary Structure 
SGIPDPQRVGRVAVLMGGTSAERDISLRSGGAILAALQRCGYDAEAYDPRDRALEGLRG
CCCCCHHHHCEEEEEECCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHCCCC
YDVVFIALHGRGGEDGTVQGLLDLLGIPYTGSGVLGSALGMDKWRCKRLWQGSGLPTPAG
CEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCC
QLLTGDRPVLDEGVGYPVIVKPAREGSSLGMSRVEGPEELAEAYRVAAAYDDTVLAEAWV
CEECCCCCCHHCCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHHHHHHC
EGEEYTVALLGDQALPSIRLETPHAFFDYAAKYQAEDTGHHCPSGLGPEEEAELGALCRE
CCCCEEEEEECCCCCCCEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
AFIASGGNGWGRVDVMRDTGGRWWLLEVNTIPGMTDHSLVPIAAAQAGIGFDELVARILG
HHHHCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCEEHHHHHCCCHHHHHHHHHH
EALR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA