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The map label for this gene is trpC [H]

Identifier: 121998858

GI number: 121998858

Start: 2282911

End: 2283729

Strand: Reverse

Name: trpC [H]

Synonym: Hhal_2079

Alternate gene names: 121998858

Gene position: 2283729-2282911 (Counterclockwise)

Preceding gene: 121998859

Following gene: 121998857

Centisome position: 85.26

GC content: 70.94

Gene sequence:

>819_bases
ATGAGCGCGCCCGGGACGCCGGATATCCTGCGCCGCATCCTGCGCCGTAAGGTCGAGGAGGTGGTCGAGCGGGCCGAGAG
CCGCTCGCTGCGCGAGCTCTCGGCCGCTGCGGCCGATCTGCCGCCGACCCGCGGGTTCCGCGACGCGCTGCTGCAGCGGA
TCGAGGCCGGGGGTACCGGGGTGATCGCCGAGATCAAGCGGGCCTCGCCGAGCCGTGGCGTGATCCGCGAGGACTTCCAG
CCGGCGGCTATCGCCGTCGATTATCAGCGTCATGGTGCCGCGTGCCTGTCGGTCCTGACCGACCGCGACTTCTTCCAGGG
CGACGACGCCCACCTGCAGGCGGCCCGCGAGGCCGTTCAGCTGCCGGTGCTCCGCAAGGATTTCACCGTCGATACCTATC
AGGTCTATGAGGCCCGCGTCCTCGGGGCCGACTGCATCCTGCTCATCGCCGCGGCGCTGGGCGACGCGCAGCTGGCCGAG
CTGCACGCCTTGGCGGTCGAGCTGGGCATGGATGTGCTGATCGAGGTCCACGATGCCGAGGAACTGGCCCGGGTCGGGCC
GCTGGGGCCTGCCCTGGTCGGTGTGAACAACCGCGATCTGCGGACCTTCCACACAGACCTGGCGACCAGTGAGGTGTTGT
CCGAGTCGATGCCGGCCGGCGCGCTGGCGGTGACCGAGAGCGGCATCCACACCCGTGAGGACGTGGCACGCATGCACGCG
GCGGGGATCCACGCCTTCCTGGTCGGCGAGGCCTTCATGTCGGCCCCAAGCCCCGGGGCACGGCTCGCCGAGCTGTTCGG
GAGCCCCGCCGGGGTGTAA

Upstream 100 bases:

>100_bases
ATCTGCGTCGTGGTGTGGAGCGAGCCCGGGAACTCATGACCTCCGGTGCCGCCGCTCAGACGCTGGAGCGCTTCGTGGCG
ACGACCAAGGAACTCGCCCA

Downstream 100 bases:

>100_bases
CCGGCCCCCCTGGGCGAGCGGGTTCCCGGGGGCCGTGGCGGAACGGTGGCAGTCATGACGCTGTCCACCACAAAGGTGGC
GTTATCGCCAGATTTGTGCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSAPGTPDILRRILRRKVEEVVERAESRSLRELSAAAADLPPTRGFRDALLQRIEAGGTGVIAEIKRASPSRGVIREDFQ
PAAIAVDYQRHGAACLSVLTDRDFFQGDDAHLQAAREAVQLPVLRKDFTVDTYQVYEARVLGADCILLIAAALGDAQLAE
LHALAVELGMDVLIEVHDAEELARVGPLGPALVGVNNRDLRTFHTDLATSEVLSESMPAGALAVTESGIHTREDVARMHA
AGIHAFLVGEAFMSAPSPGARLAELFGSPAGV

Sequences:

>Translated_272_residues
MSAPGTPDILRRILRRKVEEVVERAESRSLRELSAAAADLPPTRGFRDALLQRIEAGGTGVIAEIKRASPSRGVIREDFQ
PAAIAVDYQRHGAACLSVLTDRDFFQGDDAHLQAAREAVQLPVLRKDFTVDTYQVYEARVLGADCILLIAAALGDAQLAE
LHALAVELGMDVLIEVHDAEELARVGPLGPALVGVNNRDLRTFHTDLATSEVLSESMPAGALAVTESGIHTREDVARMHA
AGIHAFLVGEAFMSAPSPGARLAELFGSPAGV
>Mature_271_residues
SAPGTPDILRRILRRKVEEVVERAESRSLRELSAAAADLPPTRGFRDALLQRIEAGGTGVIAEIKRASPSRGVIREDFQP
AAIAVDYQRHGAACLSVLTDRDFFQGDDAHLQAAREAVQLPVLRKDFTVDTYQVYEARVLGADCILLIAAALGDAQLAEL
HALAVELGMDVLIEVHDAEELARVGPLGPALVGVNNRDLRTFHTDLATSEVLSESMPAGALAVTESGIHTREDVARMHAA
GIHAFLVGEAFMSAPSPGARLAELFGSPAGV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=247, Percent_Identity=40.080971659919, Blast_Score=154, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6322638, Length=277, Percent_Identity=37.9061371841155, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29026; Mature: 28895

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGTPDILRRILRRKVEEVVERAESRSLRELSAAAADLPPTRGFRDALLQRIEAGGTG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
VIAEIKRASPSRGVIREDFQPAAIAVDYQRHGAACLSVLTDRDFFQGDDAHLQAAREAVQ
HHHHHHHCCCCCCCHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LPVLRKDFTVDTYQVYEARVLGADCILLIAAALGDAQLAELHALAVELGMDVLIEVHDAE
CCCHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHEEEECCHH
ELARVGPLGPALVGVNNRDLRTFHTDLATSEVLSESMPAGALAVTESGIHTREDVARMHA
HHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
AGIHAFLVGEAFMSAPSPGARLAELFGSPAGV
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SAPGTPDILRRILRRKVEEVVERAESRSLRELSAAAADLPPTRGFRDALLQRIEAGGTG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCC
VIAEIKRASPSRGVIREDFQPAAIAVDYQRHGAACLSVLTDRDFFQGDDAHLQAAREAVQ
HHHHHHHCCCCCCCHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LPVLRKDFTVDTYQVYEARVLGADCILLIAAALGDAQLAELHALAVELGMDVLIEVHDAE
CCCHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHEEEECCHH
ELARVGPLGPALVGVNNRDLRTFHTDLATSEVLSESMPAGALAVTESGIHTREDVARMHA
HHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
AGIHAFLVGEAFMSAPSPGARLAELFGSPAGV
HHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA