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The map label for this gene is mutT [C]

Identifier: 121998804

GI number: 121998804

Start: 2227836

End: 2228804

Strand: Reverse

Name: mutT [C]

Synonym: Hhal_2025

Alternate gene names: 121998804

Gene position: 2228804-2227836 (Counterclockwise)

Preceding gene: 121998805

Following gene: 121998793

Centisome position: 83.21

GC content: 74.2

Gene sequence:

>969_bases
GTGCATACGGCATCGCCCGCCGCGCCGATCCACGTGGCCGCCGCCGTGGTCCGCGGCGAAGACCAGCGCGTACTGGTCCA
GTGCCGGCCGGATCACCTCGATCACGGCGGTCTGTGGGAGTTCCCCGGGGGCAAGATTGAGCCCGGTGAGTCGGTCGCCG
ACGCCTTGGTCCGCGAGCTGGACGAGGAGCTGGGTATCCGTGTCCGTCCGGGGGCGCTGCGCATCCGCGTGCCGTGGGAC
TACGGCCACCGGCGCGTGGTGCTCCACGTCCTCGATGTGAACGAGTGGACGGGGCGTCCCATCGGCCGCGAGGGCCAGGC
GGTGGACTGGCTCACCCCCGAGGCGATGGCCGAGCGGGCCTGGCCCGCCGCCAACTGGCCGATCATCCGTTCGCTGCAGC
TCCCCGACCGGTATCTGATCACCCCCGTGGAGCCAGCGGATGCCGATGCCTGGCTGGCCCGACTGGATGCGGCCCTGGCG
CGCGGTGTGCGCCTGGTTCAGCTGCGTCGCCCAGATCTCGACGTGGAGGCCTGGGTGCGTCTGGGGCGCGCCCTGCGCCG
GCGCTGTGACGCCCACGGTGCGTGGCTGCTAGCCAACGGACCGGCGGAACAGGCCCGGGCGGTGGGCGCCGACGGGGTGC
ACTGGAGCAGTCGCGTGCTGGCCGAGGGGCCGCAACGCCCGGGGTGGGCGCGGTGGGTGGGCGCTTCTTGCCACAACGGC
GACGAGCTGGAGCGCGCCGCCGCCTGCGGGGCCGATTTCGCGCTGTTGTCACCGGTGCAGTGGACGGCCAGCCATCCGGA
ACAGAGCGGCATGGGGTGGGAGCGTTTCGCCGCCTGGGTGGCCGGGGCGCGCCTGCCGGTCTACGCCCTCGGCGGCGTGG
GCCCGGCGGATATCCACCGGGCTCGGGCCTGCGGCGGGCAGGGAGTGGCGGCTATCCGCGGCCTGCTGGCGGAGGCGGGC
CGCCGATAG

Upstream 100 bases:

>100_bases
AGCTCGGCCGCGGGCCGGCAGCGGCCACCGTGTGGACCTGCGACTTCACGGCGGAGTACGTCCGCATCAACGCCGAGTAT
CGAACCTGAGCGAGGCCCCG

Downstream 100 bases:

>100_bases
CGGTCGCGGTTTTACAGCGTGCAGCGGGCCAGCCGGAACGACACGTCGGCCCCCACGGGCTCCGGGCGGCTGCGGGTGTC
GGGCTGGCGCAGGAAGCGGA

Product: mutator MutT protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MHTASPAAPIHVAAAVVRGEDQRVLVQCRPDHLDHGGLWEFPGGKIEPGESVADALVRELDEELGIRVRPGALRIRVPWD
YGHRRVVLHVLDVNEWTGRPIGREGQAVDWLTPEAMAERAWPAANWPIIRSLQLPDRYLITPVEPADADAWLARLDAALA
RGVRLVQLRRPDLDVEAWVRLGRALRRRCDAHGAWLLANGPAEQARAVGADGVHWSSRVLAEGPQRPGWARWVGASCHNG
DELERAAACGADFALLSPVQWTASHPEQSGMGWERFAAWVAGARLPVYALGGVGPADIHRARACGGQGVAAIRGLLAEAG
RR

Sequences:

>Translated_322_residues
MHTASPAAPIHVAAAVVRGEDQRVLVQCRPDHLDHGGLWEFPGGKIEPGESVADALVRELDEELGIRVRPGALRIRVPWD
YGHRRVVLHVLDVNEWTGRPIGREGQAVDWLTPEAMAERAWPAANWPIIRSLQLPDRYLITPVEPADADAWLARLDAALA
RGVRLVQLRRPDLDVEAWVRLGRALRRRCDAHGAWLLANGPAEQARAVGADGVHWSSRVLAEGPQRPGWARWVGASCHNG
DELERAAACGADFALLSPVQWTASHPEQSGMGWERFAAWVAGARLPVYALGGVGPADIHRARACGGQGVAAIRGLLAEAG
RR
>Mature_322_residues
MHTASPAAPIHVAAAVVRGEDQRVLVQCRPDHLDHGGLWEFPGGKIEPGESVADALVRELDEELGIRVRPGALRIRVPWD
YGHRRVVLHVLDVNEWTGRPIGREGQAVDWLTPEAMAERAWPAANWPIIRSLQLPDRYLITPVEPADADAWLARLDAALA
RGVRLVQLRRPDLDVEAWVRLGRALRRRCDAHGAWLLANGPAEQARAVGADGVHWSSRVLAEGPQRPGWARWVGASCHNG
DELERAAACGADFALLSPVQWTASHPEQSGMGWERFAAWVAGARLPVYALGGVGPADIHRARACGGQGVAAIRGLLAEAG
RR

Specific function: Involved In The Go System Responsible For Removing An Oxidatively Damaged Form Of Guanine (7,8-Dihydro-8-Oxoguanine) From DNA And The Nucleotide Pool. 8-Oxo-Dgtp Is Inserted Opposite Da And Dc Residues Of Template DNA With Almost Equal Efficiency Thus Le

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=124, Percent_Identity=33.0645161290323, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788056, Length=123, Percent_Identity=37.3983739837398, Blast_Score=74, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: 3.6.1.-; 2.5.1.3

Molecular weight: Translated: 35051; Mature: 35051

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTASPAAPIHVAAAVVRGEDQRVLVQCRPDHLDHGGLWEFPGGKIEPGESVADALVREL
CCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCHHHHHHHHHHH
DEELGIRVRPGALRIRVPWDYGHRRVVLHVLDVNEWTGRPIGREGQAVDWLTPEAMAERA
HHHCCCEECCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHC
WPAANWPIIRSLQLPDRYLITPVEPADADAWLARLDAALARGVRLVQLRRPDLDVEAWVR
CCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHH
LGRALRRRCDAHGAWLLANGPAEQARAVGADGVHWSSRVLAEGPQRPGWARWVGASCHNG
HHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHEECCCCCCC
DELERAAACGADFALLSPVQWTASHPEQSGMGWERFAAWVAGARLPVYALGGVGPADIHR
HHHHHHHHCCCCHHHHCCCCCCCCCCHHCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHH
ARACGGQGVAAIRGLLAEAGRR
HHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHTASPAAPIHVAAAVVRGEDQRVLVQCRPDHLDHGGLWEFPGGKIEPGESVADALVREL
CCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEECCCCCCCCCCHHHHHHHHHHH
DEELGIRVRPGALRIRVPWDYGHRRVVLHVLDVNEWTGRPIGREGQAVDWLTPEAMAERA
HHHCCCEECCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHC
WPAANWPIIRSLQLPDRYLITPVEPADADAWLARLDAALARGVRLVQLRRPDLDVEAWVR
CCCCCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHH
LGRALRRRCDAHGAWLLANGPAEQARAVGADGVHWSSRVLAEGPQRPGWARWVGASCHNG
HHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCCCCCHHHHCCCCCCCHHHEECCCCCCC
DELERAAACGADFALLSPVQWTASHPEQSGMGWERFAAWVAGARLPVYALGGVGPADIHR
HHHHHHHHCCCCHHHHCCCCCCCCCCHHCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHH
ARACGGQGVAAIRGLLAEAGRR
HHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]