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The map label for this gene is hemL

Identifier: 121998790

GI number: 121998790

Start: 2215256

End: 2216536

Strand: Reverse

Name: hemL

Synonym: Hhal_2011

Alternate gene names: 121998790

Gene position: 2216536-2215256 (Counterclockwise)

Preceding gene: 121998791

Following gene: 121998789

Centisome position: 82.75

GC content: 69.71

Gene sequence:

>1281_bases
ATGCAGCGCACCCATCAGTTATTCCAGCAGGCCCGGGAGCTGATCCCCGGGGGCGTCAACTCCCCGGTGCGCGCGTTCAA
GGGGGTCGGTGGCGAGCCGATCTTCTTCGAGCGCGGCGAGGGGCCGTATATGTGGGACGTGGACGGCAAGCGCTACGTCG
ATTACGTCTGTTCCTGGGGGCCGCTGGTCGCCGGGCACGCCGACCCGGAGATCGTCCGGCGCGTTCAGGAGACCGCCGCC
AAGGGGCTCTCCTTCGGCACCCCGGTGGAGCTCGAGGTGGAGATGGCCCGCACCCTCTGCCAGCACGTGCCGTCGCTGGA
GATGGTGCGCCTGGTCAACTCCGGCACCGAGGCGACCATGAGTGCCCTGCGCCTGGCCCGCGGCTTTACCGGTCGCGACA
AGATCGTCAAGTTCCAGGGCAACTATCACGGTCACGTCGACGCCCTGCTGGCGCAGGCCGGCTCCGGCGCCCTGACCCTG
GGCGTGCCCGGTTGTCCCGGTGTCCCCGAGGCGGTGGTCGCCGAGACGCTCACTGTGCCCTATAACGATATCGAGGCGGT
GGAGCAGTGCTTCAACGAACACGGCAGCGAGATCGCTGCGGTCATCGTCGAGCCGGTGGCCGGCAACATGAACTGCGTGC
CGCCAGTGCCCGGCTTCCTGGAGAAGCTGCGCGAGGTCTGCGACCGCACCGACGCCCTGCTGATCTTCGATGAGGTGATG
ACCGGCTTCCGCGTCGGGCCGCAGTGCGCCCAGGGGCGCTACGGCATCACCCCGGATCTGACGTGCCTGGGCAAGGTCGT
CGGCGGCGGCATGCCGGTCGGCGCCTTCGGCGGCCGGCGCGAGATCATGGAGGGGCTGGCCCCGACCGGTGGGGTCTACC
AGGCCGGGACGCTCTCCGGAAACCCGGTGACCATGGCCGCCGGGCTGGCGACCCTGGAGCGGATCACTGCGCCGGGTGCC
TTCGAGGGGCTGGAGCAGACCACCACGCGGGTGGTCGACGGCATCAAGGAGCGCGCCGACGCCGCGGGCATCCCGCTGGC
CACCAACCAAGCGGGCAGCATGTTCGGCCTGTTCTTCACCGACGACGCGCCGGTGACCCGTTTCGAGCAGGTCAAGGCGT
GCGACCTGGATGCGTTCAACCGCTTCTTCCACGCCATGCTCGACGAGGGGGTCTACCTGGCCCCGGCGGCCTTCGAGGCC
GGCTTCGTCTCGCTGGCCCACGACGATAACGCCGTGCAGGAGACCCTGGACGCTGCCGAGCGCGCCTTCGCCCGCGTCTG
A

Upstream 100 bases:

>100_bases
CGAGGATCCGGAGGCGGCCGCCCGGCAGCTCGTCGCCCAGTGGCAGCGCAGTCGGTAGAATCCCGTCCTGATACCGAATC
ACAAGACAAGAGGAGTACCC

Downstream 100 bases:

>100_bases
GCGAGACCGCGCCGGGGCCTGCGGGTCCCGGCCCTGGTATCCGACGATCCGGCGGGGCTGCGGCCCCTCCGGATTTTTTT
TCTGCGGCCGGGCTGCGCCC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MQRTHQLFQQARELIPGGVNSPVRAFKGVGGEPIFFERGEGPYMWDVDGKRYVDYVCSWGPLVAGHADPEIVRRVQETAA
KGLSFGTPVELEVEMARTLCQHVPSLEMVRLVNSGTEATMSALRLARGFTGRDKIVKFQGNYHGHVDALLAQAGSGALTL
GVPGCPGVPEAVVAETLTVPYNDIEAVEQCFNEHGSEIAAVIVEPVAGNMNCVPPVPGFLEKLREVCDRTDALLIFDEVM
TGFRVGPQCAQGRYGITPDLTCLGKVVGGGMPVGAFGGRREIMEGLAPTGGVYQAGTLSGNPVTMAAGLATLERITAPGA
FEGLEQTTTRVVDGIKERADAAGIPLATNQAGSMFGLFFTDDAPVTRFEQVKACDLDAFNRFFHAMLDEGVYLAPAAFEA
GFVSLAHDDNAVQETLDAAERAFARV

Sequences:

>Translated_426_residues
MQRTHQLFQQARELIPGGVNSPVRAFKGVGGEPIFFERGEGPYMWDVDGKRYVDYVCSWGPLVAGHADPEIVRRVQETAA
KGLSFGTPVELEVEMARTLCQHVPSLEMVRLVNSGTEATMSALRLARGFTGRDKIVKFQGNYHGHVDALLAQAGSGALTL
GVPGCPGVPEAVVAETLTVPYNDIEAVEQCFNEHGSEIAAVIVEPVAGNMNCVPPVPGFLEKLREVCDRTDALLIFDEVM
TGFRVGPQCAQGRYGITPDLTCLGKVVGGGMPVGAFGGRREIMEGLAPTGGVYQAGTLSGNPVTMAAGLATLERITAPGA
FEGLEQTTTRVVDGIKERADAAGIPLATNQAGSMFGLFFTDDAPVTRFEQVKACDLDAFNRFFHAMLDEGVYLAPAAFEA
GFVSLAHDDNAVQETLDAAERAFARV
>Mature_426_residues
MQRTHQLFQQARELIPGGVNSPVRAFKGVGGEPIFFERGEGPYMWDVDGKRYVDYVCSWGPLVAGHADPEIVRRVQETAA
KGLSFGTPVELEVEMARTLCQHVPSLEMVRLVNSGTEATMSALRLARGFTGRDKIVKFQGNYHGHVDALLAQAGSGALTL
GVPGCPGVPEAVVAETLTVPYNDIEAVEQCFNEHGSEIAAVIVEPVAGNMNCVPPVPGFLEKLREVCDRTDALLIFDEVM
TGFRVGPQCAQGRYGITPDLTCLGKVVGGGMPVGAFGGRREIMEGLAPTGGVYQAGTLSGNPVTMAAGLATLERITAPGA
FEGLEQTTTRVVDGIKERADAAGIPLATNQAGSMFGLFFTDDAPVTRFEQVKACDLDAFNRFFHAMLDEGVYLAPAAFEA
GFVSLAHDDNAVQETLDAAERAFARV

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=298, Percent_Identity=31.8791946308725, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI37574042, Length=331, Percent_Identity=29.0030211480363, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI226442705, Length=303, Percent_Identity=29.042904290429, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI24119277, Length=305, Percent_Identity=28.5245901639344, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI13994255, Length=372, Percent_Identity=24.7311827956989, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI226442709, Length=240, Percent_Identity=31.25, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI284507298, Length=213, Percent_Identity=32.8638497652582, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=62.206572769953, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789016, Length=348, Percent_Identity=31.0344827586207, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789759, Length=309, Percent_Identity=31.7152103559871, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788044, Length=339, Percent_Identity=32.4483775811209, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI145693181, Length=316, Percent_Identity=31.9620253164557, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787560, Length=357, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786991, Length=285, Percent_Identity=30.5263157894737, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=296, Percent_Identity=30.7432432432432, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=377, Percent_Identity=27.3209549071618, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=138, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=303, Percent_Identity=28.3828382838284, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=328, Percent_Identity=26.219512195122, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357415, Length=296, Percent_Identity=29.3918918918919, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356575, Length=333, Percent_Identity=31.5315315315315, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_HALHL (A1WYL3)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003577.1
- ProteinModelPortal:   A1WYL3
- SMR:   A1WYL3
- STRING:   A1WYL3
- GeneID:   4710408
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_2011
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   HANEKIV
- PhylomeDB:   A1WYL3
- ProtClustDB:   PRK00062
- BioCyc:   HHAL349124:HHAL_2011-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 45411; Mature: 45411

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRTHQLFQQARELIPGGVNSPVRAFKGVGGEPIFFERGEGPYMWDVDGKRYVDYVCSWG
CCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEECCCCCEEECCCCHHHHHHHHCCC
PLVAGHADPEIVRRVQETAAKGLSFGTPVELEVEMARTLCQHVPSLEMVRLVNSGTEATM
CEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRDKIVKFQGNYHGHVDALLAQAGSGALTLGVPGCPGVPEAVVAETLTVP
HHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCC
YNDIEAVEQCFNEHGSEIAAVIVEPVAGNMNCVPPVPGFLEKLREVCDRTDALLIFDEVM
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHH
TGFRVGPQCAQGRYGITPDLTCLGKVVGGGMPVGAFGGRREIMEGLAPTGGVYQAGTLSG
HHCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCC
NPVTMAAGLATLERITAPGAFEGLEQTTTRVVDGIKERADAAGIPLATNQAGSMFGLFFT
CCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEE
DDAPVTRFEQVKACDLDAFNRFFHAMLDEGVYLAPAAFEAGFVSLAHDDNAVQETLDAAE
CCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCHHCCCEEEEECCCHHHHHHHHHHH
RAFARV
HHHHCC
>Mature Secondary Structure
MQRTHQLFQQARELIPGGVNSPVRAFKGVGGEPIFFERGEGPYMWDVDGKRYVDYVCSWG
CCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEECCCCCEEECCCCHHHHHHHHCCC
PLVAGHADPEIVRRVQETAAKGLSFGTPVELEVEMARTLCQHVPSLEMVRLVNSGTEATM
CEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRDKIVKFQGNYHGHVDALLAQAGSGALTLGVPGCPGVPEAVVAETLTVP
HHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHCCC
YNDIEAVEQCFNEHGSEIAAVIVEPVAGNMNCVPPVPGFLEKLREVCDRTDALLIFDEVM
CCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEHHHHH
TGFRVGPQCAQGRYGITPDLTCLGKVVGGGMPVGAFGGRREIMEGLAPTGGVYQAGTLSG
HHCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCC
NPVTMAAGLATLERITAPGAFEGLEQTTTRVVDGIKERADAAGIPLATNQAGSMFGLFFT
CCEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEE
DDAPVTRFEQVKACDLDAFNRFFHAMLDEGVYLAPAAFEAGFVSLAHDDNAVQETLDAAE
CCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCHHCCCEEEEECCCHHHHHHHHHHH
RAFARV
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA