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The map label for this gene is folC [H]

Identifier: 121998580

GI number: 121998580

Start: 1972853

End: 1974157

Strand: Reverse

Name: folC [H]

Synonym: Hhal_1801

Alternate gene names: 121998580

Gene position: 1974157-1972853 (Counterclockwise)

Preceding gene: 121998581

Following gene: 121998579

Centisome position: 73.71

GC content: 71.34

Gene sequence:

>1305_bases
ATGAACGGTGCCCGCAGGCCGCAGCCGGCCGCTCCGCCAGATCTTGAGGGTTGGCTGGCCCGACTGGAAGCGGCTCACCC
GACGGCCATCGACCTCGGTCTGGAGCGCGTGGCCGCCGTGGGCCTGCGCCTTGGTGTCCTCGCCCCGGCGGCGCGGGTGG
TTACGGTCGGTGGGACCAACGGCAAGGGGAGTGTGGCGCGGACCCTGGAGGCGCTGCTGCGCGGTCTCGGGGTGAGCACA
GCCCTCTACACCTCGCCCCATTTCCAGCGCTTTAACGAGCGGATGCGCCTCGACGGGGTCGAGGTGGCCGATGCCCCATT
GGTCAAGGCGCTGGGCCGGGTCGAGGAGGCCCGGGGCGACGCTGACGTCAGTCTGACCTATTTCGAGCATACGACCCTGG
CCGCCTTCGATCTCTTTGCGCGCAGCGGTGCTCGGGTCTGGATCCTGGAGGTGGGGCTGGGCGGGCGGCTGGACGCTGTG
AACGCCATCGACGCGGATGTGGCGGTGGTCACCCGGATTGCCCGCGACCACGCCGAATTCCTCGGCGACGACCTGCAGGC
GATTGCCGCCGAGAAGGCCGGCATCTTCCGCAAGGGGCGACCGGCGGTGATCGGTCAGCAGGACGCCCCGGCGGCGCTGC
GTCAGTCGGCGCTGGAGGTCGGCGCCGAGGTCGCGCAGGCCGGGGTGGAGTGGACGTTCTCCGCCGAGGCCGACGGGCGC
TGGTGGTGGCGCTGTGGCGAGTACCACTGGGGGGGGCTGCCGGCCTCGGGGATCCCGGGGTGCGCTGCGCGCGGCAACGT
GGCTACCGCCTTGGCCGCCCTCGTTCAGCTGCCGGAGGCGGTTGGCGTGGACGCGGCGGCCGTCGCCAGGCTCCTGGATG
GGGTGCGGGTGCCCGGGCGTCTGGAGCGGATCGAGGCCGGGTCACTGGAGTGGCTGTTGGATGTCGCGCATAATGCCGAT
GGTGCGGAGGAGCTCGCCCGGGTGCTGGATGACCGAACGGTCACCGGGCAAACGCGAGCCCTCTTCGCCGTGGCGGCGCG
CAAGGATGCCCGGGCATTGGTCGCGGCGTTGAGTGGTCGGATCGACGCCTGGTACCTGCCGCAGCTGGATGAGCCGGATA
TGCGCAACGCCGATGAACTGGCCAGCCAGCTTGCCGACGCGGGTGAGTCGGTGGTGCACTGCGGTGACGGGGTGGCGACC
ACCCTGGCCGCTCTCCAGGGCCAGGCCGGGCCCGGCGATCGGGTTGTGGTCTTTGGCTCCTTCCGCACTGTGGCCGCCGT
ACAAGCGCAGCAAGGCTGGGGGTAG

Upstream 100 bases:

>100_bases
AGAGCGCAGAGCCCGAGGCGCCGGCCGAGGAGGCCGGGCCCGCTGGGGCGGCGGGGGATCAGGCTGGTGAGAGCCAGGAC
GAGGGCGACCCCCGCAACGC

Downstream 100 bases:

>100_bases
GCGATGGATCCAAGCACGAAACGACAGTTGGTTGGGGCCGCGGTCCTGGTCGCCCTGGCCGTGATCTTCCTGCCGATGAT
CTTCTCCGGCTCCGATGAGG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpolyglutamate synthase; Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase; Dihydrofolate synthase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNGARRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTNGKGSVARTLEALLRGLGVST
ALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGDADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAV
NAIDADVAVVTRIARDHAEFLGDDLQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGR
WWWRCGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGRLERIEAGSLEWLLDVAHNAD
GAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGRIDAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVAT
TLAALQGQAGPGDRVVVFGSFRTVAAVQAQQGWG

Sequences:

>Translated_434_residues
MNGARRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTNGKGSVARTLEALLRGLGVST
ALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGDADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAV
NAIDADVAVVTRIARDHAEFLGDDLQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGR
WWWRCGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGRLERIEAGSLEWLLDVAHNAD
GAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGRIDAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVAT
TLAALQGQAGPGDRVVVFGSFRTVAAVQAQQGWG
>Mature_434_residues
MNGARRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTNGKGSVARTLEALLRGLGVST
ALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGDADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAV
NAIDADVAVVTRIARDHAEFLGDDLQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGR
WWWRCGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGRLERIEAGSLEWLLDVAHNAD
GAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGRIDAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVAT
TLAALQGQAGPGDRVVVFGSFRTVAAVQAQQGWG

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932990, Length=369, Percent_Identity=29.2682926829268, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI66932984, Length=369, Percent_Identity=29.2682926829268, Blast_Score=125, Evalue=9e-29,
Organism=Escherichia coli, GI1788654, Length=424, Percent_Identity=41.2735849056604, Blast_Score=266, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17553148, Length=156, Percent_Identity=37.8205128205128, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71984923, Length=156, Percent_Identity=37.8205128205128, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17553150, Length=156, Percent_Identity=37.8205128205128, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6323760, Length=357, Percent_Identity=27.1708683473389, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6324815, Length=333, Percent_Identity=25.5255255255255, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24641571, Length=289, Percent_Identity=29.0657439446367, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581568, Length=198, Percent_Identity=30.8080808080808, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17; =6.3.2.12 [H]

Molecular weight: Translated: 45533; Mature: 45533

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGARRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTN
CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
GKGSVARTLEALLRGLGVSTALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGD
CCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
ADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAVNAIDADVAVVTRIARDHAEF
CCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHH
LGDDLQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGR
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
WWWRCGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCH
LERIEAGSLEWLLDVAHNADGAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGR
HHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IDAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVATTLAALQGQAGPGDRVVVFGS
CCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEEEC
FRTVAAVQAQQGWG
CHHHHHHHHHCCCC
>Mature Secondary Structure
MNGARRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTN
CCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
GKGSVARTLEALLRGLGVSTALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGD
CCCHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCC
ADVSLTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAVNAIDADVAVVTRIARDHAEF
CCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHH
LGDDLQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGR
HHHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
WWWRCGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGR
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCH
LERIEAGSLEWLLDVAHNADGAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGR
HHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
IDAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVATTLAALQGQAGPGDRVVVFGS
CCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCCCCCEEEEEEC
FRTVAAVQAQQGWG
CHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3040739; 3040734; 9205837; 9278503; 1989505 [H]