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The map label for this gene is lysC [H]

Identifier: 121998431

GI number: 121998431

Start: 1804178

End: 1805428

Strand: Reverse

Name: lysC [H]

Synonym: Hhal_1652

Alternate gene names: 121998431

Gene position: 1805428-1804178 (Counterclockwise)

Preceding gene: 121998432

Following gene: 121998430

Centisome position: 67.41

GC content: 60.83

Gene sequence:

>1251_bases
ATGGGGCTGGTAGTCAAAAAATTCGGTGGGACATCGGTCGGGACGACCGAGCGCATCCAGGCAGTGGCCGAGCAGGTCAA
GGCAAGTCGTGAGGCCGGAGACGATGTGGTCGTGGTCGTCTCCGCTATGAGCGGCGAGACCAATCGCCTGGTTGAGCTTG
CCGAGTCGATTCACCCAAATCCGCCAGCACGCGAGGTGGATGTCCTGTTGTCCACCGGTGAGCAGGTCACCATCGCGCTG
CTTACGATGGCGCTGGAGCAGATCGATTGCCCCGCGCGCTGCTACACCGGTGCGCAGGTGCGGATTCTGACCGATAGTTC
ATTCAGCAGGGCGCGAATCCTCGATATCGATGCCGAGCCGTTGCAAGAGGATCTGCAGCGGGGACGTGTCGTGGTGGTTG
CGGGCTTTCAGGGTGTCGACGAGGAAGGCGCGCTCACCACGCTGGGCCGTGGTGGTTCCGATACTACGGCCGTGGCGCTG
GCAGCCGCACTGGAAGCGAGCGAGTGCCAGATTTATACCGACGTGGATGGGGTCTACACCACCGACCCGCGCGTCGTACC
CGAGGCGAGGCGGTTGGACCGTATAACGGTCGACGAGATGCTGGAACTCTCCAGTCTGGGCTCCAAGGTCCTGCAGATCC
GGGCGGTAGAGTTTGCCGGCAAGTACCGCGTGCCCCTGCGGGTGCTGTCTAGCTTCGAAGAAGGGCCTGGAACGCTCATC
ACCTACGAGGAAGAAGGAATGGAAGAGCCGCTGATTTCCGGTATTGCGTTCAACCGCGACGAGGCGAAGATCTCCGTCAT
CGGTGTGCCGGACACGCCAGGGATCGCGGCCAAGATCCTCGGGGCGGTTGCCGAGGCGAACATCGAAGTGGACATGATCA
TCCAGAACATCAGCCAGCAGGGGCTGACGGATTTCACCTTTACGGTCCACAAGCGCGATTATCAGGCCACCCTGGATCTG
GTCCGGGACAACGCTGAGCAACTCGGAGCCCGGGAAGTCTATGGCGACGACAAGATTGTCAAGCTCTCCCTGGTCGGGGT
CGGGATGCGTTCCCACGCCGGCGTGGCGAACACCATGTTCCGTGCGTTGTCCAACGAGGGGATCAACATTCAAATGATCT
CGACTTCGGAGATTAAGATCTCGGTGGTTGTCGAAGAGAAATACTTGGAGCTTGGCGTGCGCGCCTTGCACAAGGCCTTC
GAGTTGGATGTACAGCCCGTGGCCGAGCTTGAGGGTCTCTCCGACGAGTAG

Upstream 100 bases:

>100_bases
AAGCTTGGATTAAGGATAACTTGACTTAATGGCGTCTCATACTCATCCTAGCATGCTTTCAATAGGAGGCTGAGACGCCC
CTGCTAGCTGAGGAATGCCC

Downstream 100 bases:

>100_bases
CGCAGTTTCCGCCCTTTGGGGATCAGGCCTGAGGGTGCTTCAGGAGTCGGGTCGCTCCGAAGGGCGAAGCGGCCGCCCGC
TCAAAAGGCGCCGGTGGCGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MGLVVKKFGGTSVGTTERIQAVAEQVKASREAGDDVVVVVSAMSGETNRLVELAESIHPNPPAREVDVLLSTGEQVTIAL
LTMALEQIDCPARCYTGAQVRILTDSSFSRARILDIDAEPLQEDLQRGRVVVVAGFQGVDEEGALTTLGRGGSDTTAVAL
AAALEASECQIYTDVDGVYTTDPRVVPEARRLDRITVDEMLELSSLGSKVLQIRAVEFAGKYRVPLRVLSSFEEGPGTLI
TYEEEGMEEPLISGIAFNRDEAKISVIGVPDTPGIAAKILGAVAEANIEVDMIIQNISQQGLTDFTFTVHKRDYQATLDL
VRDNAEQLGAREVYGDDKIVKLSLVGVGMRSHAGVANTMFRALSNEGINIQMISTSEIKISVVVEEKYLELGVRALHKAF
ELDVQPVAELEGLSDE

Sequences:

>Translated_416_residues
MGLVVKKFGGTSVGTTERIQAVAEQVKASREAGDDVVVVVSAMSGETNRLVELAESIHPNPPAREVDVLLSTGEQVTIAL
LTMALEQIDCPARCYTGAQVRILTDSSFSRARILDIDAEPLQEDLQRGRVVVVAGFQGVDEEGALTTLGRGGSDTTAVAL
AAALEASECQIYTDVDGVYTTDPRVVPEARRLDRITVDEMLELSSLGSKVLQIRAVEFAGKYRVPLRVLSSFEEGPGTLI
TYEEEGMEEPLISGIAFNRDEAKISVIGVPDTPGIAAKILGAVAEANIEVDMIIQNISQQGLTDFTFTVHKRDYQATLDL
VRDNAEQLGAREVYGDDKIVKLSLVGVGMRSHAGVANTMFRALSNEGINIQMISTSEIKISVVVEEKYLELGVRALHKAF
ELDVQPVAELEGLSDE
>Mature_415_residues
GLVVKKFGGTSVGTTERIQAVAEQVKASREAGDDVVVVVSAMSGETNRLVELAESIHPNPPAREVDVLLSTGEQVTIALL
TMALEQIDCPARCYTGAQVRILTDSSFSRARILDIDAEPLQEDLQRGRVVVVAGFQGVDEEGALTTLGRGGSDTTAVALA
AALEASECQIYTDVDGVYTTDPRVVPEARRLDRITVDEMLELSSLGSKVLQIRAVEFAGKYRVPLRVLSSFEEGPGTLIT
YEEEGMEEPLISGIAFNRDEAKISVIGVPDTPGIAAKILGAVAEANIEVDMIIQNISQQGLTDFTFTVHKRDYQATLDLV
RDNAEQLGAREVYGDDKIVKLSLVGVGMRSHAGVANTMFRALSNEGINIQMISTSEIKISVVVEEKYLELGVRALHKAFE
LDVQPVAELEGLSDE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=284, Percent_Identity=36.2676056338028, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1790455, Length=347, Percent_Identity=32.2766570605187, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=25.9515570934256, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=371, Percent_Identity=29.1105121293801, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44833; Mature: 44702

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLVVKKFGGTSVGTTERIQAVAEQVKASREAGDDVVVVVSAMSGETNRLVELAESIHPN
CCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
PPAREVDVLLSTGEQVTIALLTMALEQIDCPARCYTGAQVRILTDSSFSRARILDIDAEP
CCCHHHHHEECCCCHHHHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCCCEEEEECCCHH
LQEDLQRGRVVVVAGFQGVDEEGALTTLGRGGSDTTAVALAAALEASECQIYTDVDGVYT
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEEE
TDPRVVPEARRLDRITVDEMLELSSLGSKVLQIRAVEFAGKYRVPLRVLSSFEEGPGTLI
CCCCCCCCHHHHCCCCHHHHHHHHHHCHHEEEEEEEECCCCCCCHHHHHHCCCCCCCCEE
TYEEEGMEEPLISGIAFNRDEAKISVIGVPDTPGIAAKILGAVAEANIEVDMIIQNISQQ
EECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
GLTDFTFTVHKRDYQATLDLVRDNAEQLGAREVYGDDKIVKLSLVGVGMRSHAGVANTMF
CCCEEEEEEECCCHHHHHHHHHCCHHHCCCHHCCCCCCEEEEEEEEECCCCCCCHHHHHH
RALSNEGINIQMISTSEIKISVVVEEKYLELGVRALHKAFELDVQPVAELEGLSDE
HHHCCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure 
GLVVKKFGGTSVGTTERIQAVAEQVKASREAGDDVVVVVSAMSGETNRLVELAESIHPN
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCC
PPAREVDVLLSTGEQVTIALLTMALEQIDCPARCYTGAQVRILTDSSFSRARILDIDAEP
CCCHHHHHEECCCCHHHHHHHHHHHHHCCCCHHCCCCCEEEEEECCCCCCEEEEECCCHH
LQEDLQRGRVVVVAGFQGVDEEGALTTLGRGGSDTTAVALAAALEASECQIYTDVDGVYT
HHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEEE
TDPRVVPEARRLDRITVDEMLELSSLGSKVLQIRAVEFAGKYRVPLRVLSSFEEGPGTLI
CCCCCCCCHHHHCCCCHHHHHHHHHHCHHEEEEEEEECCCCCCCHHHHHHCCCCCCCCEE
TYEEEGMEEPLISGIAFNRDEAKISVIGVPDTPGIAAKILGAVAEANIEVDMIIQNISQQ
EECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHC
GLTDFTFTVHKRDYQATLDLVRDNAEQLGAREVYGDDKIVKLSLVGVGMRSHAGVANTMF
CCCEEEEEEECCCHHHHHHHHHCCHHHCCCHHCCCCCCEEEEEEEEECCCCCCCHHHHHH
RALSNEGINIQMISTSEIKISVVVEEKYLELGVRALHKAFELDVQPVAELEGLSDE
HHHCCCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]