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The map label for this gene is cobB [H]

Identifier: 121998376

GI number: 121998376

Start: 1737403

End: 1738137

Strand: Reverse

Name: cobB [H]

Synonym: Hhal_1597

Alternate gene names: 121998376

Gene position: 1738137-1737403 (Counterclockwise)

Preceding gene: 121998382

Following gene: 121998374

Centisome position: 64.89

GC content: 70.61

Gene sequence:

>735_bases
GTGACGCATATTGAAAAGCGGCTGAGGCAGGTGCTTCACCGGGCGCAGCGGATTGTCGCCCTGACCGGAGCCGGCATCTC
GGCCGAGAGCGGCGTCCCCACCTTTCGAGATGCGCAGACCGGGTACTGGGAGCAGTTCGACCCCGGCGAACTGGCCACGC
CCGAGGCCTTCCGGCGCAATCCCCGTCGAGTCTGGGCGTGGTATGCGCAGCGTCGGCGCCTGGCTGAGCAGGCCCAGCCC
AACGCCGGGCACCGCGCCCTCGTCGACTGGGAGCGCCAGCTTGGCGGTCTGCGGGTCGTCACACAAAACGTGGACGGTCT
GCACCAGCGCGCTGGTAGCCAGCAGGTTACCGAGCTGCACGGCAATATCCACCGCGATCGTGTCTTCGAGGGAGCGGTGG
ATGGGGCCAGCGATGCCCCCGAGCTCCCGCGTTGCCCGTGTAGCGGCGGGTTGCTTCGCCCTGATGTGGTCTGGTTCGGC
GAGGCTCTGCCTGAAGGCACGGTGGAGGCCGCGGTGGCGGCCGTACGGGAGGCGGACCTGGTGCTGTCCGTCGGCACCTC
GTCGCTGGTTCAGCCGGCCGCATCCCTGCCCCTCGAGGCCCTGGAGCGGGACATCCCGGTGCTGGAGGTTAACCGCGAGC
CGACGCCGCTGACCCCGGTGGCGGACTGGAGTCTGCGCGGCAGCGCCGGCGAGATCCTGCCGGCGCTGGTCGGCGCGGCG
ACCGAGGCGGTCTGA

Upstream 100 bases:

>100_bases
ACGGTGGTGGACACCCGCGGCTCTTGTCGAATCGGAGGGAGCGTCGCAGACTACACCACTTGCGCGACCTTTTCCCTGAT
GGCTGGTGAGGAAATCGCAC

Downstream 100 bases:

>100_bases
GCCTCCCGGTGGGGCGCGGGTATCCGGGGATCTAGAGGAAGGCCCGCGGCACCCGTTCATCCCAGGTCTTGGCGAAGACG
CGCAGCCCGTTCTCGTAGGC

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTHIEKRLRQVLHRAQRIVALTGAGISAESGVPTFRDAQTGYWEQFDPGELATPEAFRRNPRRVWAWYAQRRRLAEQAQP
NAGHRALVDWERQLGGLRVVTQNVDGLHQRAGSQQVTELHGNIHRDRVFEGAVDGASDAPELPRCPCSGGLLRPDVVWFG
EALPEGTVEAAVAAVREADLVLSVGTSSLVQPAASLPLEALERDIPVLEVNREPTPLTPVADWSLRGSAGEILPALVGAA
TEAV

Sequences:

>Translated_244_residues
MTHIEKRLRQVLHRAQRIVALTGAGISAESGVPTFRDAQTGYWEQFDPGELATPEAFRRNPRRVWAWYAQRRRLAEQAQP
NAGHRALVDWERQLGGLRVVTQNVDGLHQRAGSQQVTELHGNIHRDRVFEGAVDGASDAPELPRCPCSGGLLRPDVVWFG
EALPEGTVEAAVAAVREADLVLSVGTSSLVQPAASLPLEALERDIPVLEVNREPTPLTPVADWSLRGSAGEILPALVGAA
TEAV
>Mature_243_residues
THIEKRLRQVLHRAQRIVALTGAGISAESGVPTFRDAQTGYWEQFDPGELATPEAFRRNPRRVWAWYAQRRRLAEQAQPN
AGHRALVDWERQLGGLRVVTQNVDGLHQRAGSQQVTELHGNIHRDRVFEGAVDGASDAPELPRCPCSGGLLRPDVVWFGE
ALPEGTVEAAVAAVREADLVLSVGTSSLVQPAASLPLEALERDIPVLEVNREPTPLTPVADWSLRGSAGEILPALVGAAT
EAV

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=252, Percent_Identity=43.2539682539683, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI6912664, Length=268, Percent_Identity=41.044776119403, Blast_Score=180, Evalue=8e-46,
Organism=Homo sapiens, GI13787215, Length=241, Percent_Identity=42.3236514522822, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI6912662, Length=272, Percent_Identity=31.9852941176471, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI7657575, Length=229, Percent_Identity=33.6244541484716, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI6912660, Length=214, Percent_Identity=34.1121495327103, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI63054862, Length=209, Percent_Identity=34.4497607655502, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI13775602, Length=217, Percent_Identity=29.9539170506912, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI13775600, Length=217, Percent_Identity=29.4930875576037, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI300797705, Length=191, Percent_Identity=28.2722513089005, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI215982798, Length=176, Percent_Identity=35.2272727272727, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI300797577, Length=252, Percent_Identity=32.1428571428571, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI300797597, Length=238, Percent_Identity=31.9327731092437, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI308199517, Length=228, Percent_Identity=40.3508771929825, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71990482, Length=272, Percent_Identity=28.6764705882353, Blast_Score=113, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17567771, Length=271, Percent_Identity=28.4132841328413, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71990487, Length=274, Percent_Identity=30.2919708029197, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17541892, Length=254, Percent_Identity=27.1653543307087, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325242, Length=243, Percent_Identity=28.3950617283951, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=267, Percent_Identity=29.9625468164794, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648389, Length=205, Percent_Identity=30.7317073170732, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137536, Length=241, Percent_Identity=28.2157676348548, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645650, Length=229, Percent_Identity=27.0742358078603, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26501; Mature: 26370

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHIEKRLRQVLHRAQRIVALTGAGISAESGVPTFRDAQTGYWEQFDPGELATPEAFRRN
CCHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
PRRVWAWYAQRRRLAEQAQPNAGHRALVDWERQLGGLRVVTQNVDGLHQRAGSQQVTELH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHH
GNIHRDRVFEGAVDGASDAPELPRCPCSGGLLRPDVVWFGEALPEGTVEAAVAAVREADL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHE
VLSVGTSSLVQPAASLPLEALERDIPVLEVNREPTPLTPVADWSLRGSAGEILPALVGAA
EEECCCHHHHHHHHHCCHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TEAV
HHCC
>Mature Secondary Structure 
THIEKRLRQVLHRAQRIVALTGAGISAESGVPTFRDAQTGYWEQFDPGELATPEAFRRN
CHHHHHHHHHHHHHHHEEHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCC
PRRVWAWYAQRRRLAEQAQPNAGHRALVDWERQLGGLRVVTQNVDGLHQRAGSQQVTELH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHH
GNIHRDRVFEGAVDGASDAPELPRCPCSGGLLRPDVVWFGEALPEGTVEAAVAAVREADL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHE
VLSVGTSSLVQPAASLPLEALERDIPVLEVNREPTPLTPVADWSLRGSAGEILPALVGAA
EEECCCHHHHHHHHHCCHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TEAV
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA