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The map label for this gene is pyrH

Identifier: 121998246

GI number: 121998246

Start: 1579742

End: 1580482

Strand: Reverse

Name: pyrH

Synonym: Hhal_1464

Alternate gene names: 121998246

Gene position: 1580482-1579742 (Counterclockwise)

Preceding gene: 121998247

Following gene: 121998245

Centisome position: 59.01

GC content: 65.86

Gene sequence:

>741_bases
GTGCCGCACTATCGCCGGATACTGCTCAAGCTCAGCGGCGAGGCGCTGCTGGGCGACGGACAATACGGGATCGCCGCCAA
TACGCTCGATCGCATTGCCGACGAACTGGCCGAGATCAACGCCATGGGGGTCGAGGTGGCGGTGGTCATTGGTGGCGGCA
ATATCTTCCGCGGGGCCGGTCTGGCCGCCTCGGGCATGGACCGGGTCACCGCCGACCATATGGGCATGCTGGCCACCGTG
ATGAACGCCCTGGCCATCCAGGATGCCCTCGAGCGGCGGAGCGTCTTCTGCCGCGTCATGTCAGCGATCAAGATCAATCA
GGTCTGCGAGGACTACATCCGCCGCCGGGCGGTCCGCCACCTGGAGAAAGGCCGGGTGGTGATCTTCGCCGCCGGTACCG
GCAACCCCTTCTTCACCACCGACTCTGCCGCCAGCCTGCGCGCCGTGGAGGTCGGGGCCGAACTGCTGCTCAAGGGGACC
AAGGTCGACGGGGTCTACAGCTCCGATCCGGTCCGCGACCCCGAGGCGAAGCGCTATCAGCAGCTCACCTACGATGAGGT
ACTGAGTAAGCGCCTGGAGGTCATGGACGCGACCGCCATCGTTCTGTGCCGCGATCAAGCGATGCGCATCATGGTCTTTG
ATATCACCAGCCCGGGTACCATGGTTGCCGCGGCCCGTGGCGAGCCGGTGGGTACCGTGGTCGATCCGGGCCTGCCCAGC
GCCCAGGAGGAATCATCGTGA

Upstream 100 bases:

>100_bases
CAAGTCCGCGACTCCTGAGCCCGGGCGGCGTTACCAGCAACGGCGGTGCCCGGGTGGCCCGGGCACCGCGCCCGCTCACT
AAAAGGCCGGAGTCATGACG

Downstream 100 bases:

>100_bases
TCGAAGATATCCAGGAAGACGCCGATCGCCGGATGGCCAAGGCCGTCGAGAGCCTCAAGCACGACCTGGCTCGGCTGCGC
ACCGGGCGCGCCCACACCAG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MPHYRRILLKLSGEALLGDGQYGIAANTLDRIADELAEINAMGVEVAVVIGGGNIFRGAGLAASGMDRVTADHMGMLATV
MNALAIQDALERRSVFCRVMSAIKINQVCEDYIRRRAVRHLEKGRVVIFAAGTGNPFFTTDSAASLRAVEVGAELLLKGT
KVDGVYSSDPVRDPEAKRYQQLTYDEVLSKRLEVMDATAIVLCRDQAMRIMVFDITSPGTMVAAARGEPVGTVVDPGLPS
AQEESS

Sequences:

>Translated_246_residues
MPHYRRILLKLSGEALLGDGQYGIAANTLDRIADELAEINAMGVEVAVVIGGGNIFRGAGLAASGMDRVTADHMGMLATV
MNALAIQDALERRSVFCRVMSAIKINQVCEDYIRRRAVRHLEKGRVVIFAAGTGNPFFTTDSAASLRAVEVGAELLLKGT
KVDGVYSSDPVRDPEAKRYQQLTYDEVLSKRLEVMDATAIVLCRDQAMRIMVFDITSPGTMVAAARGEPVGTVVDPGLPS
AQEESS
>Mature_245_residues
PHYRRILLKLSGEALLGDGQYGIAANTLDRIADELAEINAMGVEVAVVIGGGNIFRGAGLAASGMDRVTADHMGMLATVM
NALAIQDALERRSVFCRVMSAIKINQVCEDYIRRRAVRHLEKGRVVIFAAGTGNPFFTTDSAASLRAVEVGAELLLKGTK
VDGVYSSDPVRDPEAKRYQQLTYDEVLSKRLEVMDATAIVLCRDQAMRIMVFDITSPGTMVAAARGEPVGTVVDPGLPSA
QEESS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=57.0815450643777, Blast_Score=272, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_HALHL (A1WX19)

Other databases:

- EMBL:   CP000544
- RefSeq:   YP_001003033.1
- ProteinModelPortal:   A1WX19
- SMR:   A1WX19
- STRING:   A1WX19
- GeneID:   4710659
- GenomeReviews:   CP000544_GR
- KEGG:   hha:Hhal_1464
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   A1WX19
- ProtClustDB:   PRK00358
- BioCyc:   HHAL349124:HHAL_1464-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26445; Mature: 26314

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHYRRILLKLSGEALLGDGQYGIAANTLDRIADELAEINAMGVEVAVVIGGGNIFRGAG
CCHHHEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECCCC
LAASGMDRVTADHMGMLATVMNALAIQDALERRSVFCRVMSAIKINQVCEDYIRRRAVRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPFFTTDSAASLRAVEVGAELLLKGTKVDGVYSSDPVRDPEAKRYQ
HHCCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHH
QLTYDEVLSKRLEVMDATAIVLCRDQAMRIMVFDITSPGTMVAAARGEPVGTVVDPGLPS
HCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCEEEECCCCCCCEEECCCCCC
AQEESS
CCCCCC
>Mature Secondary Structure 
PHYRRILLKLSGEALLGDGQYGIAANTLDRIADELAEINAMGVEVAVVIGGGNIFRGAG
CHHHEEEEEECCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEECCCC
LAASGMDRVTADHMGMLATVMNALAIQDALERRSVFCRVMSAIKINQVCEDYIRRRAVRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEKGRVVIFAAGTGNPFFTTDSAASLRAVEVGAELLLKGTKVDGVYSSDPVRDPEAKRYQ
HHCCCEEEEEECCCCCCEECCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHH
QLTYDEVLSKRLEVMDATAIVLCRDQAMRIMVFDITSPGTMVAAARGEPVGTVVDPGLPS
HCCHHHHHHHHHHHHHHHEEEEEECCCEEEEEEEECCCCCEEEECCCCCCCEEECCCCCC
AQEESS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA