Click here to switch to the map view.

The map label for this gene is frdB [H]

Identifier: 121998231

GI number: 121998231

Start: 1561039

End: 1561803

Strand: Reverse

Name: frdB [H]

Synonym: Hhal_1449

Alternate gene names: 121998231

Gene position: 1561803-1561039 (Counterclockwise)

Preceding gene: 121998232

Following gene: 121998230

Centisome position: 58.31

GC content: 65.62

Gene sequence:

>765_bases
GTGAGCGAGTGGCAGCACATCACCCTCGAAGTGCAACGCTACCACCCGGAGCAGGATGCCGCCCCGCGCTGGCAGCGTTA
CACCGTGCCGTATACGCCGGATATGTCCGTTCTCGAGGGCCTGCAGTACATCAAGGACCATCTGGATGGCACCCTGACCT
TCCGCTGGTCGTGTCGCATGGCGATCTGCGGAAGCTGTGGCTGCATGATCGACGGCGAGCCTGAGCTGGCCTGCCACGTC
TTCCTCCGTGATTACGCGCCGGGGCCGGTGCGCGTGACGGCACTGGACCATTTCCCCATTCAGCGGGACCTGGTCATCGA
CCACACCGACTTCCTCGAGAAGCTGGAGACGGCCCGCGCTTACCTGATCCCGGCTGACGACCGGACCCCCGCTGACGGGA
CTTACCGGCAGACGCCCGAGGAGATGTCGGACTACTACGCCTACGCGCAGTGCATCAACTGTCTGCTCTGCTACGCTGCT
TGCCCGCAGTACGGCTGGCACCCAGACTTCCTGGGACCCGGGATCCTGGCGCTGGTGCAGCGGTACAACCTGGATCATCG
GGATGGGGGTAGTCGGGCCCGAGAGGGGGTAGTCGATGCCGAGGAGGGTGTCTGGGGGTGCACCCTGGTTGGCTACTGTT
CCGAGGTCTGTCCCAAGGGGGTCGACCCGGCGCGCGCGATCAATCAGAACAAGCCCGCGAGCAGCGCTCGCTATCTGCTC
GACTGGCTGCGCCCGGGCGGCCGCAAGCGGGAGGGCTCGGAATGA

Upstream 100 bases:

>100_bases
CGGGTGGTGAGACTGGGCCGGTGATCGATCACGCGCCGGTAACCATTACCCGTTCCGAGCCGCGGCGACGGGCCTATGGG
GCCGAAGGGGAGGGCCGGTC

Downstream 100 bases:

>100_bases
GTCGGCCGCACGCTTACCGCCCGACCATGCGCGGCTGGTGGCAGCGGCACCCGGCCTACCGCCGCTACCTGTTGCGGGAA
GGGAGCAGCGTTCTTCTAGC

Product: succinate dehydrogenase and fumarate reductase iron-sulfur protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSEWQHITLEVQRYHPEQDAAPRWQRYTVPYTPDMSVLEGLQYIKDHLDGTLTFRWSCRMAICGSCGCMIDGEPELACHV
FLRDYAPGPVRVTALDHFPIQRDLVIDHTDFLEKLETARAYLIPADDRTPADGTYRQTPEEMSDYYAYAQCINCLLCYAA
CPQYGWHPDFLGPGILALVQRYNLDHRDGGSRAREGVVDAEEGVWGCTLVGYCSEVCPKGVDPARAINQNKPASSARYLL
DWLRPGGRKREGSE

Sequences:

>Translated_254_residues
MSEWQHITLEVQRYHPEQDAAPRWQRYTVPYTPDMSVLEGLQYIKDHLDGTLTFRWSCRMAICGSCGCMIDGEPELACHV
FLRDYAPGPVRVTALDHFPIQRDLVIDHTDFLEKLETARAYLIPADDRTPADGTYRQTPEEMSDYYAYAQCINCLLCYAA
CPQYGWHPDFLGPGILALVQRYNLDHRDGGSRAREGVVDAEEGVWGCTLVGYCSEVCPKGVDPARAINQNKPASSARYLL
DWLRPGGRKREGSE
>Mature_253_residues
SEWQHITLEVQRYHPEQDAAPRWQRYTVPYTPDMSVLEGLQYIKDHLDGTLTFRWSCRMAICGSCGCMIDGEPELACHVF
LRDYAPGPVRVTALDHFPIQRDLVIDHTDFLEKLETARAYLIPADDRTPADGTYRQTPEEMSDYYAYAQCINCLLCYAAC
PQYGWHPDFLGPGILALVQRYNLDHRDGGSRAREGVVDAEEGVWGCTLVGYCSEVCPKGVDPARAINQNKPASSARYLLD
WLRPGGRKREGSE

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=226, Percent_Identity=31.858407079646, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1790596, Length=245, Percent_Identity=52.6530612244898, Blast_Score=276, Evalue=1e-75,
Organism=Escherichia coli, GI1786943, Length=232, Percent_Identity=35.3448275862069, Blast_Score=128, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17533915, Length=227, Percent_Identity=30.8370044052863, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322987, Length=234, Percent_Identity=33.7606837606838, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI17137106, Length=234, Percent_Identity=33.7606837606838, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24643156, Length=227, Percent_Identity=33.0396475770925, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 28783; Mature: 28651

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEWQHITLEVQRYHPEQDAAPRWQRYTVPYTPDMSVLEGLQYIKDHLDGTLTFRWSCRM
CCCCEEEEEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECE
AICGSCGCMIDGEPELACHVFLRDYAPGPVRVTALDHFPIQRDLVIDHTDFLEKLETARA
EEECCCCEEECCCCCEEEEEEEHHCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHCCE
YLIPADDRTPADGTYRQTPEEMSDYYAYAQCINCLLCYAACPQYGWHPDFLGPGILALVQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RYNLDHRDGGSRAREGVVDAEEGVWGCTLVGYCSEVCPKGVDPARAINQNKPASSARYLL
HHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHH
DWLRPGGRKREGSE
HHHCCCCCCCCCCC
>Mature Secondary Structure 
SEWQHITLEVQRYHPEQDAAPRWQRYTVPYTPDMSVLEGLQYIKDHLDGTLTFRWSCRM
CCCEEEEEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECE
AICGSCGCMIDGEPELACHVFLRDYAPGPVRVTALDHFPIQRDLVIDHTDFLEKLETARA
EEECCCCEEECCCCCEEEEEEEHHCCCCCEEEEEECCCCCCCCEEECHHHHHHHHHHCCE
YLIPADDRTPADGTYRQTPEEMSDYYAYAQCINCLLCYAACPQYGWHPDFLGPGILALVQ
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
RYNLDHRDGGSRAREGVVDAEEGVWGCTLVGYCSEVCPKGVDPARAINQNKPASSARYLL
HHCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHCCCCCCHHHHHHH
DWLRPGGRKREGSE
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3308458 [H]