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The map label for this gene is truD

Identifier: 121998215

GI number: 121998215

Start: 1545510

End: 1546526

Strand: Reverse

Name: truD

Synonym: Hhal_1433

Alternate gene names: 121998215

Gene position: 1546526-1545510 (Counterclockwise)

Preceding gene: 121998216

Following gene: 121998213

Centisome position: 57.74

GC content: 70.89

Gene sequence:

>1017_bases
TTGATCCGGGCCCACGGCGGACCCTTGGGCACGGCGCGCCTGCGCGCCTGCCCCGAGGACTTCCGCGTGGATGAGCAGCT
GCCGTTTCAGCCCTCCGGGGTGGGCGAGCACTGCCTGATCCAGGTTTGCAAACGCGGCTGGACGACCGAGGCTGTCGCCA
AGATATTGGCGGCTCGGGCGGGGGTGTCGCGGGGCGCCGTGAGCTTTGCCGGTCTCAAGGACCGGCACGCAGTGACCACC
CAGTGGTTCTCGGTGCATGCGCCGAAGGCGTGCCCGGCGCTGCTGCCGGGATGTTTAGAGGACGGCGTCGAGATCGTTGC
GGCTACCCGCAACGCCCGCAAGCTGCGCCGCGGCGCGCTCGGCGGCAACCGCTTCCGCCTGCTGGTTCGCGAAGTATCGG
CGCCGCGTCGGGCGGTGGAGCGCCGCCTGCATGCCATTTCCCGGCGGGGCGTCCCCAACTATTTCGGGCCCCAGCGTTTC
GGGCGCGGGGGGCGCAACCTGCAGCAGGCGCGGGCCTGGTTGCTCGAGGGCGAGCCGGTCCGAGGTCGTACCGTGCGTGG
GCTACTGATCTCTGCGGTGCGTTCGGATCTGTTCAACCGAGTGCTGGCCCGGCGGGTGGCAGCCGGTACCTGGGATACGT
TGCTGGCCGGAGAACGGGCGGCGCTCGATGGAACCGGTAGCCATTTTCCGGTGGTGGCGGTGGATGCCCCCCTCCGGCGG
CGTGTCGCCCAGGGGGATGTCCATCCCAGCGGGCCTTTGCCCGGGGTTGGTGGGGATCGGCCGGAAGGTGCGGTGGCGGC
GCTTGAAGACGAGGTCCTCGCCGAGGAGCCCGAGCTGCTGGCCGCACTGGCCGAGCGCGGGGTGCGCGCCGACCGCCGTC
CACTGCGCCTGATGCCCCGGCAGTTGGTCTGGCACTGGCCCGACGCACAGACCCTCTCTCTCGACTTCACGCTCACCGCC
GGGGCCTACGCCACCACGGTGATCGCGGAAGTCTTGGAGACCGCCGCGGAAGAGTGA

Upstream 100 bases:

>100_bases
ACGTCAAGGCGACGACCAGCGAGCGCCTCGGCTTCACCGGCCGGGGAGAGGGGATCGCCGCGATGGCAGTGGTCCTGGTG
GAATCGGCCCCGGGGCGGGG

Downstream 100 bases:

>100_bases
CATCGCTCCTGCCCCGGGGTTACCGCGGGCCCGGCTTGCGCAGCAGCACGTAGACGGCGCCGGTGCCGCCGTCACTCTCC
GGTGCCGAAGCGAAGGCCAG

Product: tRNA pseudouridine synthase D

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D; tRNA-uridine isomerase D [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIRAHGGPLGTARLRACPEDFRVDEQLPFQPSGVGEHCLIQVCKRGWTTEAVAKILAARAGVSRGAVSFAGLKDRHAVTT
QWFSVHAPKACPALLPGCLEDGVEIVAATRNARKLRRGALGGNRFRLLVREVSAPRRAVERRLHAISRRGVPNYFGPQRF
GRGGRNLQQARAWLLEGEPVRGRTVRGLLISAVRSDLFNRVLARRVAAGTWDTLLAGERAALDGTGSHFPVVAVDAPLRR
RVAQGDVHPSGPLPGVGGDRPEGAVAALEDEVLAEEPELLAALAERGVRADRRPLRLMPRQLVWHWPDAQTLSLDFTLTA
GAYATTVIAEVLETAAEE

Sequences:

>Translated_338_residues
MIRAHGGPLGTARLRACPEDFRVDEQLPFQPSGVGEHCLIQVCKRGWTTEAVAKILAARAGVSRGAVSFAGLKDRHAVTT
QWFSVHAPKACPALLPGCLEDGVEIVAATRNARKLRRGALGGNRFRLLVREVSAPRRAVERRLHAISRRGVPNYFGPQRF
GRGGRNLQQARAWLLEGEPVRGRTVRGLLISAVRSDLFNRVLARRVAAGTWDTLLAGERAALDGTGSHFPVVAVDAPLRR
RVAQGDVHPSGPLPGVGGDRPEGAVAALEDEVLAEEPELLAALAERGVRADRRPLRLMPRQLVWHWPDAQTLSLDFTLTA
GAYATTVIAEVLETAAEE
>Mature_338_residues
MIRAHGGPLGTARLRACPEDFRVDEQLPFQPSGVGEHCLIQVCKRGWTTEAVAKILAARAGVSRGAVSFAGLKDRHAVTT
QWFSVHAPKACPALLPGCLEDGVEIVAATRNARKLRRGALGGNRFRLLVREVSAPRRAVERRLHAISRRGVPNYFGPQRF
GRGGRNLQQARAWLLEGEPVRGRTVRGLLISAVRSDLFNRVLARRVAAGTWDTLLAGERAALDGTGSHFPVVAVDAPLRR
RVAQGDVHPSGPLPGVGGDRPEGAVAALEDEVLAEEPELLAALAERGVRADRRPLRLMPRQLVWHWPDAQTLSLDFTLTA
GAYATTVIAEVLETAAEE

Specific function: Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Escherichia coli, GI1789102, Length=335, Percent_Identity=43.5820895522388, Blast_Score=243, Evalue=1e-65,
Organism=Drosophila melanogaster, GI21355799, Length=131, Percent_Identity=33.587786259542, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 36601; Mature: 36601

Theoretical pI: Translated: 10.98; Mature: 10.98

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRAHGGPLGTARLRACPEDFRVDEQLPFQPSGVGEHCLIQVCKRGWTTEAVAKILAARA
CCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
GVSRGAVSFAGLKDRHAVTTQWFSVHAPKACPALLPGCLEDGVEIVAATRNARKLRRGAL
CCCCCCEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHEEHHHHHHHHHHHHCC
GGNRFRLLVREVSAPRRAVERRLHAISRRGVPNYFGPQRFGRGGRNLQQARAWLLEGEPV
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCC
RGRTVRGLLISAVRSDLFNRVLARRVAAGTWDTLLAGERAALDGTGSHFPVVAVDAPLRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEECCHHHH
RVAQGDVHPSGPLPGVGGDRPEGAVAALEDEVLAEEPELLAALAERGVRADRRPLRLMPR
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCH
QLVWHWPDAQTLSLDFTLTAGAYATTVIAEVLETAAEE
HHEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRAHGGPLGTARLRACPEDFRVDEQLPFQPSGVGEHCLIQVCKRGWTTEAVAKILAARA
CCCCCCCCCCHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHC
GVSRGAVSFAGLKDRHAVTTQWFSVHAPKACPALLPGCLEDGVEIVAATRNARKLRRGAL
CCCCCCEECCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCHHEEHHHHHHHHHHHHCC
GGNRFRLLVREVSAPRRAVERRLHAISRRGVPNYFGPQRFGRGGRNLQQARAWLLEGEPV
CCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCC
RGRTVRGLLISAVRSDLFNRVLARRVAAGTWDTLLAGERAALDGTGSHFPVVAVDAPLRR
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCEEEECCHHHH
RVAQGDVHPSGPLPGVGGDRPEGAVAALEDEVLAEEPELLAALAERGVRADRRPLRLMPR
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCH
QLVWHWPDAQTLSLDFTLTAGAYATTVIAEVLETAAEE
HHEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA