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The map label for this gene is moaE [H]

Identifier: 121998143

GI number: 121998143

Start: 1470766

End: 1471188

Strand: Reverse

Name: moaE [H]

Synonym: Hhal_1361

Alternate gene names: 121998143

Gene position: 1471188-1470766 (Counterclockwise)

Preceding gene: 121998144

Following gene: 121998142

Centisome position: 54.93

GC content: 69.27

Gene sequence:

>423_bases
ATGAATCGCGTGACCGACGACCCCATCGCGCTGGAGCCGCTGCTGACCGAGACCGCCGACCCCTCGGCCGGGGCCCTGGT
GGTCTTCGGCGGCACGGTGCGGGATCACCACGAGGGGCGACGTGTGGCGGCCATCGCCTACTCGGCTTATCGCCCGATGG
CCGAGCGTGTGCTCGCCGAGTTGGAGGCTGAGGTGACCGAGCGCTACGGCGTGCAGGCGTGCCGAATCGTGCACCGCGTT
GGCGAGTTGGCTGTGGGCGAGGAGAGCGTGGTGGTAGTGGTGCGTGCAGCCCACCGGGCCGAGGCCTTCGAGGCGGGGCG
CTACGCCATCGACACGCTGAAGGTCCGGGCGCCATTCTGGAAGGACGAGCATTATGAGGACGGGACCCGCGCGTATCAAT
CGGGTGTGCCGCTGGCACCCTGA

Upstream 100 bases:

>100_bases
TACCGGCGTTTCTGTGCCCTGCAGCTGGGTGCTCTGGAGATCGAGACGCCTGGAAACGGGTCGCCCGTGTCATAATGACG
CACAATGGCGAGGAGGTGGC

Downstream 100 bases:

>100_bases
CTGGCGCGGTAGGGACAACGACTGCCGGGGGAACGGTATGACGAATCTGACCCGCGAGGCCGTGGAGCAGGGGGTGAGTC
AGGTCCAGGATTACTACTTG

Product: molybdopterin biosynthesis MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MNRVTDDPIALEPLLTETADPSAGALVVFGGTVRDHHEGRRVAAIAYSAYRPMAERVLAELEAEVTERYGVQACRIVHRV
GELAVGEESVVVVVRAAHRAEAFEAGRYAIDTLKVRAPFWKDEHYEDGTRAYQSGVPLAP

Sequences:

>Translated_140_residues
MNRVTDDPIALEPLLTETADPSAGALVVFGGTVRDHHEGRRVAAIAYSAYRPMAERVLAELEAEVTERYGVQACRIVHRV
GELAVGEESVVVVVRAAHRAEAFEAGRYAIDTLKVRAPFWKDEHYEDGTRAYQSGVPLAP
>Mature_140_residues
MNRVTDDPIALEPLLTETADPSAGALVVFGGTVRDHHEGRRVAAIAYSAYRPMAERVLAELEAEVTERYGVQACRIVHRV
GELAVGEESVVVVVRAAHRAEAFEAGRYAIDTLKVRAPFWKDEHYEDGTRAYQSGVPLAP

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=109, Percent_Identity=40.3669724770642, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI1787003, Length=107, Percent_Identity=45.7943925233645, Blast_Score=97, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17509279, Length=127, Percent_Identity=35.4330708661417, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21356259, Length=125, Percent_Identity=36.8, Blast_Score=93, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 15357; Mature: 15357

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVTDDPIALEPLLTETADPSAGALVVFGGTVRDHHEGRRVAAIAYSAYRPMAERVLAE
CCCCCCCCEECCHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
LEAEVTERYGVQACRIVHRVGELAVGEESVVVVVRAAHRAEAFEAGRYAIDTLKVRAPFW
HHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEEEEEECCCC
KDEHYEDGTRAYQSGVPLAP
CCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNRVTDDPIALEPLLTETADPSAGALVVFGGTVRDHHEGRRVAAIAYSAYRPMAERVLAE
CCCCCCCCEECCHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHH
LEAEVTERYGVQACRIVHRVGELAVGEESVVVVVRAAHRAEAFEAGRYAIDTLKVRAPFW
HHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEEEEEECCCC
KDEHYEDGTRAYQSGVPLAP
CCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]