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The map label for this gene is cbiC [H]

Identifier: 121998131

GI number: 121998131

Start: 1458685

End: 1459353

Strand: Reverse

Name: cbiC [H]

Synonym: Hhal_1349

Alternate gene names: 121998131

Gene position: 1459353-1458685 (Counterclockwise)

Preceding gene: 121998132

Following gene: 121998130

Centisome position: 54.48

GC content: 72.5

Gene sequence:

>669_bases
ATGTCTCGCGAGCCGTCCGTGACCGAGCAGCAGACCGCCTCCGGGCGCCAGATCGAGGCGTGCTCCTTCGCCCGCGTCGA
CGCCGAGGCCGGGGATCGCAGTGCCTACGACGCGGCGCAGTGGGCGGTGGTCCGGCGCATGATCCACGCCACGGCGGATT
TCGACTTCAATGGCGTGACCCGCTTCCATCCCCGTGCTGTGACCGCGGGGATGGAGGCCATCCGCGCCGGGGCGCCGGTC
TTCGTCGACGTGGAGATGATCCGTGTCGGTCTGTCCGCCGCGCGGCTGGGGCACTTCGGGATCGAGGCGCACTGCCTGAT
GGCGGACCCGCGGGCGGCGGAGCGGGCCCAGCAGGCGGGGACCACCCGAGCTGAGCAGGCGGTTGCCCTGGCCGCCGAGC
AGGGGTGGCTCGATGGCGCCATCGTAGCCGTGGGTAATGCCCCGACGGCGCTGCGAGCAGTCCTTGAGCGGATCCACGGT
GGCGTGGTGGCGCCGCGATTGCTGATCGCCATGCCGGTCGGGTTTGTCGCTGCCGCAGAGTCCAGCGAGGAGGCCATGGC
GCAGCAGCAGGTGCCGTGGATCGCCACCGCCGGGCGCAAGGGCGGGACGCCGCCGGTGGTGGCCTGTCTGCACGCCCTGC
TCGCCCTGGCCGAGGAGGGAGACGGGTGA

Upstream 100 bases:

>100_bases
GGCGCGTGCGGGACAGGCGATGCTCGAGTGCGACGGCTGCCCGCACCGCGCGGCGGCCGCGCACCACCACCATCACCACC
ACCACTGAAGAGGTGCGAGG

Downstream 100 bases:

>100_bases
CCCCGGTCTGCACCATCGTCGGTGTGCTCGATGACGGTCCCGACGGGCTGGCACCGGTGGCCCGTGAGGCCATTGCCGGC
GCCGATCTGCTCATCGGCGG

Product: precorrin-8X methylmutase CbiC/CobH

Products: hydrogenobyrinate

Alternate protein names: Cobalt-precorrin isomerase; HBA synthase [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSREPSVTEQQTASGRQIEACSFARVDAEAGDRSAYDAAQWAVVRRMIHATADFDFNGVTRFHPRAVTAGMEAIRAGAPV
FVDVEMIRVGLSAARLGHFGIEAHCLMADPRAAERAQQAGTTRAEQAVALAAEQGWLDGAIVAVGNAPTALRAVLERIHG
GVVAPRLLIAMPVGFVAAAESSEEAMAQQQVPWIATAGRKGGTPPVVACLHALLALAEEGDG

Sequences:

>Translated_222_residues
MSREPSVTEQQTASGRQIEACSFARVDAEAGDRSAYDAAQWAVVRRMIHATADFDFNGVTRFHPRAVTAGMEAIRAGAPV
FVDVEMIRVGLSAARLGHFGIEAHCLMADPRAAERAQQAGTTRAEQAVALAAEQGWLDGAIVAVGNAPTALRAVLERIHG
GVVAPRLLIAMPVGFVAAAESSEEAMAQQQVPWIATAGRKGGTPPVVACLHALLALAEEGDG
>Mature_221_residues
SREPSVTEQQTASGRQIEACSFARVDAEAGDRSAYDAAQWAVVRRMIHATADFDFNGVTRFHPRAVTAGMEAIRAGAPVF
VDVEMIRVGLSAARLGHFGIEAHCLMADPRAAERAQQAGTTRAEQAVALAAEQGWLDGAIVAVGNAPTALRAVLERIHGG
VVAPRLLIAMPVGFVAAAESSEEAMAQQQVPWIATAGRKGGTPPVVACLHALLALAEEGDG

Specific function: Catalyzes the conversion of cobalt-precorrin-8X to cobyrinic acid; a methyl migration reaction during the transformation of cobalt-precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: 5.4.1.2

Molecular weight: Translated: 23232; Mature: 23100

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSREPSVTEQQTASGRQIEACSFARVDAEAGDRSAYDAAQWAVVRRMIHATADFDFNGVT
CCCCCCCCHHHHCCCCEECHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
RFHPRAVTAGMEAIRAGAPVFVDVEMIRVGLSAARLGHFGIEAHCLMADPRAAERAQQAG
EECCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHC
TTRAEQAVALAAEQGWLDGAIVAVGNAPTALRAVLERIHGGVVAPRLLIAMPVGFVAAAE
CHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SSEEAMAQQQVPWIATAGRKGGTPPVVACLHALLALAEEGDG
CHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SREPSVTEQQTASGRQIEACSFARVDAEAGDRSAYDAAQWAVVRRMIHATADFDFNGVT
CCCCCCCHHHHCCCCEECHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
RFHPRAVTAGMEAIRAGAPVFVDVEMIRVGLSAARLGHFGIEAHCLMADPRAAERAQQAG
EECCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHC
TTRAEQAVALAAEQGWLDGAIVAVGNAPTALRAVLERIHGGVVAPRLLIAMPVGFVAAAE
CHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
SSEEAMAQQQVPWIATAGRKGGTPPVVACLHALLALAEEGDG
CHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Precorrin 8X

Specific reaction: precorrin-8X = hydrogenobyrinate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]