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The map label for this gene is gyrB [H]

Identifier: 121998014

GI number: 121998014

Start: 1328717

End: 1331140

Strand: Reverse

Name: gyrB [H]

Synonym: Hhal_1224

Alternate gene names: 121998014

Gene position: 1331140-1328717 (Counterclockwise)

Preceding gene: 121998015

Following gene: 121998009

Centisome position: 49.7

GC content: 65.14

Gene sequence:

>2424_bases
ATGACGACGGAGATTACGCCGCAGTACGACTCGGAAAGCATTCAGGTGCTGCGTGGCCTCGACGCCGTCCGCAAGCGCCC
GGGCATGTACATCGGCGATACGGACGACGGTACCGGCCTCCACCACATGGTCTTCGAGGTCCTCGATAACTCCATCGACG
AGGCGCTGGCCGGCCACTGCTCCGAGATCACCGTCACCCTCCACGCCGATCACTCCGTCACCGTGACCGACAACGGCCGC
GGTATACCAGTGGACATCCACGCCGAGGAGGGCGTCCCCGCTGCGCAGGTGATCATGACCGTGCTGCACGCCGGCGGGAA
GTTCGATGACAACAGTTACAAGGTCTCCGGTGGTCTGCACGGGGTCGGTGTCTCCGTCGTCAACGCGCTCTCTGAGCGCT
TGCGCCTGGTCATCGAGCGCGAGGGCAAGGTCCACGTTCAGGAGTACGCCGATGGCGCGCCGGTCACCTCGCTCAAGGTT
GTCGGCGAGACCGAACAGACCGGGACGCGCATCACCTTCAAGCCGTCCGAGGCGATCTTTACCGAGGTCCAGTACAACTA
CGATATCCTCGCCAAGCGCTTCCGCGAGCTCTCCTTCCTCAATCCGGGGGTGCGCGTCGTCCTCAAGGACGAACGCACCG
AGAAAGAGGATGTCTTCGAGTACACCGGCGGGATCCGCGCCTTCGTTGAACACCTCAACCGCAACAAGACTCCGCTTCAC
CCGACGGTGTTCTATGTCACCGCCTGGCGGGATGGGGTCGGCGTGGATGTGGCCATGCAGTGGAACGACTCCTACCAGGA
GAATATCTTCTGTTTCACCAACAACATCCCGCAGCGTGACGGCGGCACTCACCTGGCCGGGTTCCGCGGCGCCCTCACCC
GCACGGTCAATGGCTATCTCGAGGCCGAGGGGTATCTCAAGAAGCTCAAGTCGACGCCCAGCGGCGAGGACGTGCGCGAG
GGGCTGACCGCTGTGGTCTCGGTCAAGGCCCCGGATCCCAAGTTCTCCTCGCAGACCAAAGACAAGCTCGTCTCCTCCGA
GGTCAAGGGCATCGTCGAGTCGCTCCTCTCCGAGTCGCTGCAGACATTCCTTGCAGAACACCCGCCGGAGGCCCGCGCCA
TCGCCGAGCGCGTCATCCAGGCCAGCCGGGCCCGCGAGGCCGCGCGCAAGGCCCGGGAGATGACCCGGCGCAAGGACGCG
CTGGATATCGCCGGCCTACCGGGCAAGCTGGCCGACTGTCAGGAGCGCGATCCGGCTAAGTCGGAGATCTACCTGGTCGA
GGGCGACTCCGCCGGCGGTTCTGCCAAGCAGGGGCGCGATCGCCGTACCCAGGCGATCCTCCCGCTCAAGGGCAAGATCC
TCAACGTCGAGAAGGCGCGATTCGACAAGATGCTCTCCTCGGCGGAGGTCGGCACCCTCATCACCGCGCTCGGCTGCGGC
ATCGGCCGTGACGACTTCGATCCGGACAAGCTCCGCTACCACCGGATCATCATCATGACCGACGCCGATGTGGACGGCTC
CCACATCCGCACCCTGCTCCTGACCTTCTTCTACCGGCAGATGCGCGAGCTGGTCGAGCGCGGCAACGTTTATATCGCCC
AGCCACCGCTCTACAAGATCAAGCGCGGCAAACAGGAACACTACGTCAAGGATGAACGCGAGCTGACCGAGTATCTCCTG
GAGCTCGCCCTGGACGGCTCAGCCTTGCACCCTGGCGGGGGCGCACCTCCGATCAGCGGCGAGGCTCTCGGTCGGCTGGC
ACGCCGCTACTACGAGGCCATGGAGCTCATCGAGCATGTCTCGCGGCGCTGGGACTCGGCGATCCTCGAGCAGATGACCA
CGCTGGCGCCGCGTACCGAGGACGACATCACCGACGCCCAGGCCATGCAGGCGTGGTTCGATCAACTGGTGCAGCAGGTC
GAAGCCGCCACGGATGCCAGCATGCGCTATCGGGTGACGGTCCAGCGCGGCCCGGATGGGGGCTTCCAGGAGGCCATCGT
GACCCGGCGTCGCCACGGTCTGGATCAGGAGTACCGCTTCAATCCGCAGTTCTTCCTGTCGGCGGAGTACGACACCCTGA
AGGCCCTGGCCTCGCTGCTGGACGGCCTCCTCCACGAAGGGGCCGAGGTGGTTCGCGGCGAACGCCGTCGGCCGGTTACC
AGCCTGCGCGAGGCGGTGGAATGGCTGATGGAGGAGGCCAAGCGCGGGCAGACCATCCAGCGCTACAAGGGTCTGGGTGA
GATGAATCCGGATCAGCTTTGGGAGACCACCATGAACCCGGAGACCCGCCGGCTCCTGCGGGTGACCATCGACGATGCGG
TGGCCGCCGACGAGATCTTCACCACGCTGATGGGGGATCATGTCGAGCCGCGGCGCGATTTCATCGAGCGCAACGCGCTG
GCGGTCTCCAACCTCGACGTCTGA

Upstream 100 bases:

>100_bases
TGGTATCAGGTATGCGAAGGGAGGGTGTCAGCGATGGTATAATGGCCTTTTACGACCGGCACTTCGGTCCAGACGTACCC
TTGTAGAGGCTGAATCATCG

Downstream 100 bases:

>100_bases
TCCCGATGCCCCTCCGGACCGGCGGTCGCTCCGGAGGGGCCGCCGCCGGTTACCGGGCCGCTGGGCGGCTCTCCAGCTCC
GCCATCCGCGCCTCGATCCA

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MTTEITPQYDSESIQVLRGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDEALAGHCSEITVTLHADHSVTVTDNGR
GIPVDIHAEEGVPAAQVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSERLRLVIEREGKVHVQEYADGAPVTSLKV
VGETEQTGTRITFKPSEAIFTEVQYNYDILAKRFRELSFLNPGVRVVLKDERTEKEDVFEYTGGIRAFVEHLNRNKTPLH
PTVFYVTAWRDGVGVDVAMQWNDSYQENIFCFTNNIPQRDGGTHLAGFRGALTRTVNGYLEAEGYLKKLKSTPSGEDVRE
GLTAVVSVKAPDPKFSSQTKDKLVSSEVKGIVESLLSESLQTFLAEHPPEARAIAERVIQASRAREAARKAREMTRRKDA
LDIAGLPGKLADCQERDPAKSEIYLVEGDSAGGSAKQGRDRRTQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
IGRDDFDPDKLRYHRIIIMTDADVDGSHIRTLLLTFFYRQMRELVERGNVYIAQPPLYKIKRGKQEHYVKDERELTEYLL
ELALDGSALHPGGGAPPISGEALGRLARRYYEAMELIEHVSRRWDSAILEQMTTLAPRTEDDITDAQAMQAWFDQLVQQV
EAATDASMRYRVTVQRGPDGGFQEAIVTRRRHGLDQEYRFNPQFFLSAEYDTLKALASLLDGLLHEGAEVVRGERRRPVT
SLREAVEWLMEEAKRGQTIQRYKGLGEMNPDQLWETTMNPETRRLLRVTIDDAVAADEIFTTLMGDHVEPRRDFIERNAL
AVSNLDV

Sequences:

>Translated_807_residues
MTTEITPQYDSESIQVLRGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDEALAGHCSEITVTLHADHSVTVTDNGR
GIPVDIHAEEGVPAAQVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSERLRLVIEREGKVHVQEYADGAPVTSLKV
VGETEQTGTRITFKPSEAIFTEVQYNYDILAKRFRELSFLNPGVRVVLKDERTEKEDVFEYTGGIRAFVEHLNRNKTPLH
PTVFYVTAWRDGVGVDVAMQWNDSYQENIFCFTNNIPQRDGGTHLAGFRGALTRTVNGYLEAEGYLKKLKSTPSGEDVRE
GLTAVVSVKAPDPKFSSQTKDKLVSSEVKGIVESLLSESLQTFLAEHPPEARAIAERVIQASRAREAARKAREMTRRKDA
LDIAGLPGKLADCQERDPAKSEIYLVEGDSAGGSAKQGRDRRTQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
IGRDDFDPDKLRYHRIIIMTDADVDGSHIRTLLLTFFYRQMRELVERGNVYIAQPPLYKIKRGKQEHYVKDERELTEYLL
ELALDGSALHPGGGAPPISGEALGRLARRYYEAMELIEHVSRRWDSAILEQMTTLAPRTEDDITDAQAMQAWFDQLVQQV
EAATDASMRYRVTVQRGPDGGFQEAIVTRRRHGLDQEYRFNPQFFLSAEYDTLKALASLLDGLLHEGAEVVRGERRRPVT
SLREAVEWLMEEAKRGQTIQRYKGLGEMNPDQLWETTMNPETRRLLRVTIDDAVAADEIFTTLMGDHVEPRRDFIERNAL
AVSNLDV
>Mature_806_residues
TTEITPQYDSESIQVLRGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDEALAGHCSEITVTLHADHSVTVTDNGRG
IPVDIHAEEGVPAAQVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSERLRLVIEREGKVHVQEYADGAPVTSLKVV
GETEQTGTRITFKPSEAIFTEVQYNYDILAKRFRELSFLNPGVRVVLKDERTEKEDVFEYTGGIRAFVEHLNRNKTPLHP
TVFYVTAWRDGVGVDVAMQWNDSYQENIFCFTNNIPQRDGGTHLAGFRGALTRTVNGYLEAEGYLKKLKSTPSGEDVREG
LTAVVSVKAPDPKFSSQTKDKLVSSEVKGIVESLLSESLQTFLAEHPPEARAIAERVIQASRAREAARKAREMTRRKDAL
DIAGLPGKLADCQERDPAKSEIYLVEGDSAGGSAKQGRDRRTQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCGI
GRDDFDPDKLRYHRIIIMTDADVDGSHIRTLLLTFFYRQMRELVERGNVYIAQPPLYKIKRGKQEHYVKDERELTEYLLE
LALDGSALHPGGGAPPISGEALGRLARRYYEAMELIEHVSRRWDSAILEQMTTLAPRTEDDITDAQAMQAWFDQLVQQVE
AATDASMRYRVTVQRGPDGGFQEAIVTRRRHGLDQEYRFNPQFFLSAEYDTLKALASLLDGLLHEGAEVVRGERRRPVTS
LREAVEWLMEEAKRGQTIQRYKGLGEMNPDQLWETTMNPETRRLLRVTIDDAVAADEIFTTLMGDHVEPRRDFIERNALA
VSNLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=553, Percent_Identity=25.1356238698011, Blast_Score=130, Evalue=7e-30,
Organism=Homo sapiens, GI19913406, Length=581, Percent_Identity=25.3012048192771, Blast_Score=124, Evalue=4e-28,
Organism=Escherichia coli, GI48994957, Length=804, Percent_Identity=64.8009950248756, Blast_Score=1076, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=554, Percent_Identity=41.6967509025271, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17535065, Length=543, Percent_Identity=24.8618784530387, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI212645845, Length=502, Percent_Identity=24.9003984063745, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI212645657, Length=157, Percent_Identity=33.7579617834395, Blast_Score=73, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=571, Percent_Identity=26.4448336252189, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17136538, Length=512, Percent_Identity=27.34375, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 90195; Mature: 90064

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTEITPQYDSESIQVLRGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDEALAGHC
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SEITVTLHADHSVTVTDNGRGIPVDIHAEEGVPAAQVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSERLRLVIEREGKVHVQEYADGAPVTSLKVVGETEQTGTRITFKPSEAIF
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCEEEEECCCCCCCCEEEECCCHHHH
TEVQYNYDILAKRFRELSFLNPGVRVVLKDERTEKEDVFEYTGGIRAFVEHLNRNKTPLH
HHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCHHHHHHHHHCCCCCCCC
PTVFYVTAWRDGVGVDVAMQWNDSYQENIFCFTNNIPQRDGGTHLAGFRGALTRTVNGYL
CEEEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EAEGYLKKLKSTPSGEDVREGLTAVVSVKAPDPKFSSQTKDKLVSSEVKGIVESLLSESL
HHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QTFLAEHPPEARAIAERVIQASRAREAARKAREMTRRKDALDIAGLPGKLADCQERDPAK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SEIYLVEGDSAGGSAKQGRDRRTQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
CEEEEEECCCCCCCCCCCCCCHHCEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDDFDPDKLRYHRIIIMTDADVDGSHIRTLLLTFFYRQMRELVERGNVYIAQPPLYKI
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHH
KRGKQEHYVKDERELTEYLLELALDGSALHPGGGAPPISGEALGRLARRYYEAMELIEHV
HCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRRWDSAILEQMTTLAPRTEDDITDAQAMQAWFDQLVQQVEAATDASMRYRVTVQRGPDG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
GFQEAIVTRRRHGLDQEYRFNPQFFLSAEYDTLKALASLLDGLLHEGAEVVRGERRRPVT
CHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHH
SLREAVEWLMEEAKRGQTIQRYKGLGEMNPDQLWETTMNPETRRLLRVTIDDAVAADEIF
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHCCCCCCHHHEEEEEHHHHHHHHHHH
TTLMGDHVEPRRDFIERNALAVSNLDV
HHHHCCCCCHHHHHHHHCCEEECCCCC
>Mature Secondary Structure 
TTEITPQYDSESIQVLRGLDAVRKRPGMYIGDTDDGTGLHHMVFEVLDNSIDEALAGHC
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCCCC
SEITVTLHADHSVTVTDNGRGIPVDIHAEEGVPAAQVIMTVLHAGGKFDDNSYKVSGGLH
CEEEEEEECCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
GVGVSVVNALSERLRLVIEREGKVHVQEYADGAPVTSLKVVGETEQTGTRITFKPSEAIF
HHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCCEEEEECCCCCCCCEEEECCCHHHH
TEVQYNYDILAKRFRELSFLNPGVRVVLKDERTEKEDVFEYTGGIRAFVEHLNRNKTPLH
HHHHCCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHCHHHHHHHHHCCCCCCCC
PTVFYVTAWRDGVGVDVAMQWNDSYQENIFCFTNNIPQRDGGTHLAGFRGALTRTVNGYL
CEEEEEEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
EAEGYLKKLKSTPSGEDVREGLTAVVSVKAPDPKFSSQTKDKLVSSEVKGIVESLLSESL
HHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QTFLAEHPPEARAIAERVIQASRAREAARKAREMTRRKDALDIAGLPGKLADCQERDPAK
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
SEIYLVEGDSAGGSAKQGRDRRTQAILPLKGKILNVEKARFDKMLSSAEVGTLITALGCG
CEEEEEECCCCCCCCCCCCCCHHCEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCC
IGRDDFDPDKLRYHRIIIMTDADVDGSHIRTLLLTFFYRQMRELVERGNVYIAQPPLYKI
CCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHH
KRGKQEHYVKDERELTEYLLELALDGSALHPGGGAPPISGEALGRLARRYYEAMELIEHV
HCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SRRWDSAILEQMTTLAPRTEDDITDAQAMQAWFDQLVQQVEAATDASMRYRVTVQRGPDG
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCC
GFQEAIVTRRRHGLDQEYRFNPQFFLSAEYDTLKALASLLDGLLHEGAEVVRGERRRPVT
CHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHH
SLREAVEWLMEEAKRGQTIQRYKGLGEMNPDQLWETTMNPETRRLLRVTIDDAVAADEIF
HHHHHHHHHHHHHHCCCHHHHHCCCCCCCHHHHHHCCCCCCHHHEEEEEHHHHHHHHHHH
TTLMGDHVEPRRDFIERNALAVSNLDV
HHHHCCCCCHHHHHHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]