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The map label for this gene is menA [H]

Identifier: 121997963

GI number: 121997963

Start: 1279842

End: 1280780

Strand: Reverse

Name: menA [H]

Synonym: Hhal_1173

Alternate gene names: 121997963

Gene position: 1280780-1279842 (Counterclockwise)

Preceding gene: 121997965

Following gene: 121997962

Centisome position: 47.82

GC content: 69.65

Gene sequence:

>939_bases
ATGGATCGGTCGATGACGCAAATGTCCCCGCGCCCGTCCTGGCCGACGATCGTCTGGCACGCGATCCGGCCGCGCACGCT
ACCGCTTTCCCTGTCCCCGATCCTCGCGGGGTCCGCTGTGGGGTGGGTAGAGAGCGGCGTCCTGCGCCTCGACGTGACCC
TGGTGGCGGCGTTATCGACGGCAGCGATCCAGATCGGGACCAACCTGCAGAACGACGCCGCCGACACCCTGAACCAGACC
GACAGCGCCGAGCGCATCGGTCCGGTGCGGGTCACCGAGCGCGGTTGGCTGACTCCGCGGCAGGTCATGGCGGCCGCCTA
CGGTGCCTTCGCCCTGGCGCTGTTCTGTGGTCTCTACCTGGTGGCGATCGGCGGCCTGCCCATTCTGGTGCTCGGCATCC
TCTCGGTACTGGCCGGATACGCCTACTCCGGCGGCCCGTTCCCGATCTCCCGCGGTCCGCTGGGGGAGTTGTTTGTCATC
TTCTTCTTCGGGTTGGTCGCCGTCGGCGGTGTGGTCTACCTGTATACCGGGTCGATCAGTCCACCCGCGCTGGTGATGGG
AGTGACCCTCGGGCTGCCGGCCGCAGCCGTGCTGCTGGTCAACAATCTGCGTGATCGCGAGGGCGACCGCGAGGCCGGGC
GCGCGACGCTGGCCATCCTGCTCGGACCGGTGGGTTCGGTCTGGTTGTTCGGTGGCCTGCTCGCCGGTGTGGCGCTGGGG
CTGCTCGGTATGGTTGCGTTCGGCGTGCCGTGGACCGGCGCCGCCCTGGGGCTGGCTGTGCTGCCCTTCGGGGTAAGGAT
CTGGCGCGCGCTGATGGGCGCGGCCAGCGGCGAGGATTACAATCAGTGCCTGGCCCGCACCGGGGTGTTCCAGCTGCTGC
TCGCCCTGGTCGCCGGGGCCGGGTTGGTGGTCGGGGCGTATCTGCACGGGGCCGCGTAG

Upstream 100 bases:

>100_bases
TCCCGTGTCAGACTGGACCTCTCCCCGCGGACCGGTCACAATCGCCGCATCCCGGCGCGGTTCGCGCTCCGTTCGTTCTT
GCTGCTGAACAGGTTCTCGC

Downstream 100 bases:

>100_bases
CGGCCCGGCAGGACGCGGCGCCGCGGATTGTTGATAGGGTCCGGGCCAGGCGCTATGGTCCGGCTGATTGCCTGCGCGGC
GGTGCCCGCGCCGGTTTCAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDRSMTQMSPRPSWPTIVWHAIRPRTLPLSLSPILAGSAVGWVESGVLRLDVTLVAALSTAAIQIGTNLQNDAADTLNQT
DSAERIGPVRVTERGWLTPRQVMAAAYGAFALALFCGLYLVAIGGLPILVLGILSVLAGYAYSGGPFPISRGPLGELFVI
FFFGLVAVGGVVYLYTGSISPPALVMGVTLGLPAAAVLLVNNLRDREGDREAGRATLAILLGPVGSVWLFGGLLAGVALG
LLGMVAFGVPWTGAALGLAVLPFGVRIWRALMGAASGEDYNQCLARTGVFQLLLALVAGAGLVVGAYLHGAA

Sequences:

>Translated_312_residues
MDRSMTQMSPRPSWPTIVWHAIRPRTLPLSLSPILAGSAVGWVESGVLRLDVTLVAALSTAAIQIGTNLQNDAADTLNQT
DSAERIGPVRVTERGWLTPRQVMAAAYGAFALALFCGLYLVAIGGLPILVLGILSVLAGYAYSGGPFPISRGPLGELFVI
FFFGLVAVGGVVYLYTGSISPPALVMGVTLGLPAAAVLLVNNLRDREGDREAGRATLAILLGPVGSVWLFGGLLAGVALG
LLGMVAFGVPWTGAALGLAVLPFGVRIWRALMGAASGEDYNQCLARTGVFQLLLALVAGAGLVVGAYLHGAA
>Mature_312_residues
MDRSMTQMSPRPSWPTIVWHAIRPRTLPLSLSPILAGSAVGWVESGVLRLDVTLVAALSTAAIQIGTNLQNDAADTLNQT
DSAERIGPVRVTERGWLTPRQVMAAAYGAFALALFCGLYLVAIGGLPILVLGILSVLAGYAYSGGPFPISRGPLGELFVI
FFFGLVAVGGVVYLYTGSISPPALVMGVTLGLPAAAVLLVNNLRDREGDREAGRATLAILLGPVGSVWLFGGLLAGVALG
LLGMVAFGVPWTGAALGLAVLPFGVRIWRALMGAASGEDYNQCLARTGVFQLLLALVAGAGLVVGAYLHGAA

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=311, Percent_Identity=29.5819935691318, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1790365, Length=253, Percent_Identity=33.9920948616601, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32231; Mature: 32231

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSMTQMSPRPSWPTIVWHAIRPRTLPLSLSPILAGSAVGWVESGVLRLDVTLVAALST
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCHHHHHHCCHHEEHHHHHHHHHH
AAIQIGTNLQNDAADTLNQTDSAERIGPVRVTERGWLTPRQVMAAAYGAFALALFCGLYL
HHHEECCCCCCHHHHHHHCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VAIGGLPILVLGILSVLAGYAYSGGPFPISRGPLGELFVIFFFGLVAVGGVVYLYTGSIS
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCC
PPALVMGVTLGLPAAAVLLVNNLRDREGDREAGRATLAILLGPVGSVWLFGGLLAGVALG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLGMVAFGVPWTGAALGLAVLPFGVRIWRALMGAASGEDYNQCLARTGVFQLLLALVAGA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
GLVVGAYLHGAA
HHHHHHHHHCCC
>Mature Secondary Structure
MDRSMTQMSPRPSWPTIVWHAIRPRTLPLSLSPILAGSAVGWVESGVLRLDVTLVAALST
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCHHHHHHCCHHEEHHHHHHHHHH
AAIQIGTNLQNDAADTLNQTDSAERIGPVRVTERGWLTPRQVMAAAYGAFALALFCGLYL
HHHEECCCCCCHHHHHHHCCCCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VAIGGLPILVLGILSVLAGYAYSGGPFPISRGPLGELFVIFFFGLVAVGGVVYLYTGSIS
HHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEECCCC
PPALVMGVTLGLPAAAVLLVNNLRDREGDREAGRATLAILLGPVGSVWLFGGLLAGVALG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLGMVAFGVPWTGAALGLAVLPFGVRIWRALMGAASGEDYNQCLARTGVFQLLLALVAGA
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCC
GLVVGAYLHGAA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]