Click here to switch to the map view.

The map label for this gene is tyrS [H]

Identifier: 121997667

GI number: 121997667

Start: 954208

End: 955410

Strand: Reverse

Name: tyrS [H]

Synonym: Hhal_0876

Alternate gene names: 121997667

Gene position: 955410-954208 (Counterclockwise)

Preceding gene: 121997670

Following gene: 121997666

Centisome position: 35.67

GC content: 65.92

Gene sequence:

>1203_bases
ATGACGATGGAAGATGCACAGGCGCTGATTCGACGCGGGGTTGAGGAGATCATTCCGGAGGCGGAGCTCGACGAGCGCCT
GCGATCGGGCAAGCGGCTGCGCATCAAGGCCGGCTTCGATCCCACCGCGCCGGATCTGCACCTTGGCCACACCGTGCTGA
TCAACAAGCTGCGCCAGTTTCAGGACCTGGGGCACGAGGTGCTGTTCCTGATCGGCGATTTCACCGCCACCATTGGTGAT
CCGAGCGGCAAGAGCGCCACCCGTCCGGCACTGACTCCGGAGGAGGTGCGTCAGAACGCGCGCACCTATGAGGAGCAGAT
CTACGCCATCCTCGACCCGAAGCGCACCCGGCTGGTCTTCAACTCCGACTGGATGGGCACCATGCAGGCTGGCGATCTGA
TCCAGCTCGCCTCCCGCTACACCGTGGCGCGCATGCTCGAGCGGGACGACTTCCATCAGCGCTACCAGGCCGGCTCCGCC
ATCGCTATCCACGAATTCCTCTACCCGCTGATCCAGGGCTACGACTCGGTGGCCCTTGAGGCGGACATCGAACTCGGCGG
CACCGATCAGCGGTTCAACCTGCTCGTCGGGCGCGAGTTGCAGCGCCAGTTCGGGCAGAAGCCGCAGACGGTGCTGACCA
TGCCCCTGTTGGTCGGGCTCGACGGGCACAAGAAGATGTCCAAGTCCCTGGGCAACTACGTTGGCGTCAAGGAGTCCGCC
GAGGACATCTACGCCAAGCTGATGTCCATCTCCGACGACCTGATGTGGCGTTACTTCGAGTTGCTCAGCCTGCGTCCGTG
GCGCGAGGTCGAGGCCCTGCAGGCGCGGATCCGCGATGAGGGGATGAACCCCCGGGATGCCAAGGACGCCCTGGCCTACG
AGCTGGCGGAGCGCTTCTGCGGTGCCGTCGAGGCGCAGCGCGCCCGTGAGGCCTTCGTGGCCCGCTTCCGCCACGGCGCC
GTACCGGAGGATGTGCCGCAGGTCACCCTGACCTATGATGAGCAAGGGGGGGTAGGCATCGCCGCCGCCCTAAAAGAGGC
CGGGCTCGTGGGCTCGACCTCCGAGGGGCTGCGCATGGTTCGTCAGGGGGCTGTGCGGGTCGATGGCGAGCGGATCGAAG
ACCCCAAGGCGCGCCTGGAGTCCGGCCGTGCGCACCTGCTGCAGGTGGGCAAACGCCGGTTTGCGCGGGTGAGTGAAAAT
TAG

Upstream 100 bases:

>100_bases
CGAGTGCGCGCTCGCCGTCGGCGCGGCGTCGGGCTCGGCCACAATCCGGGGGTTACGGTACAATACGCGATTTTACATAG
CGATGGGCAGGGGGCGAGCC

Downstream 100 bases:

>100_bases
GGGTTGACCTACGCTGCGCAGCCCGTAGAATGCGCATCTCTCGACGGGGCGGAGACGCCCGGTCGGACCAGACAAAGAGG
GGATTCGCCGGCGGCTGAAT

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTMEDAQALIRRGVEEIIPEAELDERLRSGKRLRIKAGFDPTAPDLHLGHTVLINKLRQFQDLGHEVLFLIGDFTATIGD
PSGKSATRPALTPEEVRQNARTYEEQIYAILDPKRTRLVFNSDWMGTMQAGDLIQLASRYTVARMLERDDFHQRYQAGSA
IAIHEFLYPLIQGYDSVALEADIELGGTDQRFNLLVGRELQRQFGQKPQTVLTMPLLVGLDGHKKMSKSLGNYVGVKESA
EDIYAKLMSISDDLMWRYFELLSLRPWREVEALQARIRDEGMNPRDAKDALAYELAERFCGAVEAQRAREAFVARFRHGA
VPEDVPQVTLTYDEQGGVGIAAALKEAGLVGSTSEGLRMVRQGAVRVDGERIEDPKARLESGRAHLLQVGKRRFARVSEN

Sequences:

>Translated_400_residues
MTMEDAQALIRRGVEEIIPEAELDERLRSGKRLRIKAGFDPTAPDLHLGHTVLINKLRQFQDLGHEVLFLIGDFTATIGD
PSGKSATRPALTPEEVRQNARTYEEQIYAILDPKRTRLVFNSDWMGTMQAGDLIQLASRYTVARMLERDDFHQRYQAGSA
IAIHEFLYPLIQGYDSVALEADIELGGTDQRFNLLVGRELQRQFGQKPQTVLTMPLLVGLDGHKKMSKSLGNYVGVKESA
EDIYAKLMSISDDLMWRYFELLSLRPWREVEALQARIRDEGMNPRDAKDALAYELAERFCGAVEAQRAREAFVARFRHGA
VPEDVPQVTLTYDEQGGVGIAAALKEAGLVGSTSEGLRMVRQGAVRVDGERIEDPKARLESGRAHLLQVGKRRFARVSEN
>Mature_399_residues
TMEDAQALIRRGVEEIIPEAELDERLRSGKRLRIKAGFDPTAPDLHLGHTVLINKLRQFQDLGHEVLFLIGDFTATIGDP
SGKSATRPALTPEEVRQNARTYEEQIYAILDPKRTRLVFNSDWMGTMQAGDLIQLASRYTVARMLERDDFHQRYQAGSAI
AIHEFLYPLIQGYDSVALEADIELGGTDQRFNLLVGRELQRQFGQKPQTVLTMPLLVGLDGHKKMSKSLGNYVGVKESAE
DIYAKLMSISDDLMWRYFELLSLRPWREVEALQARIRDEGMNPRDAKDALAYELAERFCGAVEAQRAREAFVARFRHGAV
PEDVPQVTLTYDEQGGVGIAAALKEAGLVGSTSEGLRMVRQGAVRVDGERIEDPKARLESGRAHLLQVGKRRFARVSEN

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=401, Percent_Identity=26.6832917705736, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1787925, Length=419, Percent_Identity=28.6396181384248, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI25145802, Length=371, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325160, Length=314, Percent_Identity=26.1146496815287, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130383, Length=403, Percent_Identity=27.2952853598015, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 44951; Mature: 44820

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMEDAQALIRRGVEEIIPEAELDERLRSGKRLRIKAGFDPTAPDLHLGHTVLINKLRQF
CCHHHHHHHHHHCHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
QDLGHEVLFLIGDFTATIGDPSGKSATRPALTPEEVRQNARTYEEQIYAILDPKRTRLVF
HHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
NSDWMGTMQAGDLIQLASRYTVARMLERDDFHQRYQAGSAIAIHEFLYPLIQGYDSVALE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEE
ADIELGGTDQRFNLLVGRELQRQFGQKPQTVLTMPLLVGLDGHKKMSKSLGNYVGVKESA
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHCCCCHHH
EDIYAKLMSISDDLMWRYFELLSLRPWREVEALQARIRDEGMNPRDAKDALAYELAERFC
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAVEAQRAREAFVARFRHGAVPEDVPQVTLTYDEQGGVGIAAALKEAGLVGSTSEGLRMV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHH
RQGAVRVDGERIEDPKARLESGRAHLLQVGKRRFARVSEN
HHCCCEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TMEDAQALIRRGVEEIIPEAELDERLRSGKRLRIKAGFDPTAPDLHLGHTVLINKLRQF
CHHHHHHHHHHCHHHHCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHH
QDLGHEVLFLIGDFTATIGDPSGKSATRPALTPEEVRQNARTYEEQIYAILDPKRTRLVF
HHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
NSDWMGTMQAGDLIQLASRYTVARMLERDDFHQRYQAGSAIAIHEFLYPLIQGYDSVALE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEE
ADIELGGTDQRFNLLVGRELQRQFGQKPQTVLTMPLLVGLDGHKKMSKSLGNYVGVKESA
EEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCHHHHHHHHHHHCCCCHHH
EDIYAKLMSISDDLMWRYFELLSLRPWREVEALQARIRDEGMNPRDAKDALAYELAERFC
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GAVEAQRAREAFVARFRHGAVPEDVPQVTLTYDEQGGVGIAAALKEAGLVGSTSEGLRMV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHH
RQGAVRVDGERIEDPKARLESGRAHLLQVGKRRFARVSEN
HHCCCEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA