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The map label for this gene is hemH [H]

Identifier: 121997610

GI number: 121997610

Start: 900800

End: 901915

Strand: Reverse

Name: hemH [H]

Synonym: Hhal_0819

Alternate gene names: 121997610

Gene position: 901915-900800 (Counterclockwise)

Preceding gene: 121997612

Following gene: 121997609

Centisome position: 33.67

GC content: 71.06

Gene sequence:

>1116_bases
ATGAAACTGTATTCCGCGAAGAGCACGTTCCAGCACGATGAAGCGCCCGCCGTGGGGGTCCTGGTCGCCAACCTGGGCAC
CCCGGATGAGCCGACGGAACCGGCCCTGCGCCGCTATCTGCGCCAGTTCCTCTCGGATCCGCGGGTCATCGAGATCCCCC
GCTGGCGCTGGTGGCCGATCCTCTACGGGATCGTGCTGCGTACCCGGCCCAAGAAGTCCGCGGCCGCGTACAGTGAGGTC
TGGGAGCAGGACGGCTCGCCGCTGCTGAGCATCGGCCAGCGCCAGGCGGCGGGCATCCGTCAGCGCCTGCAGGCGCTGAA
CGACCGCGGCCCCTTCGCCGTGGAGCTGGGCATGCGCTACGGCAACCCCTCCATCCCGGCGGCCCTGCGCCGGCTGCGCG
AGTCCGGGGCGCGGCGGATCCTGGTCCTGCCGCTCTACCCGCAGTACTCCGCCTCCACCACCGGCTCCACCTTCGACGCC
GTGGCGCGCGAGCTGATGGGCTGGCGCTGGGTGCCGGAGCTGCGCATGGTGGGTCAATACCACGACGAGCCGGTCTACAT
CCAGGCGCTGGCCCGCTCCATCCGCGAGCACTGGGAGCACGAAGGCCGTGGCGAGCGGCTGCTCTTCTCCTACCACGGCG
TACCGGAGCGCTACCTGCTCGATGGCGACCCGTACCACTGCCAGTGCCTGAAGACCTCGCGCCTGGTGGCCGAGGAGCTG
GGCCTGGAGCCCGGCACCTGGGACGTCACCTTCCAGTCGCGCTTCGGTAACGAGGAGTGGCTCAAGCCGTACACCGACGA
GACGGTCACCCGCCTGGCCCAGGAAGGCGTCAAGCACCTGGACGTGGTCTGCCCCGGTTTCTCGGCGGACTGCCTGGAGA
CCCTCGAGGAGATCGCCGGCGAGAATCGCGAGTACTTCGAGGAGAGCGGTGGTGAGCGCCTGCGCTACATCCCGGCGCTC
AACGACCGCCCCGACCACCTGGAGGCGCTGACCGCGCTGGTCCTCCAGCACGGCCAGGGGTGGCGTGAGGTGGACGGCGG
TCGCGACCCGGAGGCCGAGCAGCGCCGCCGCGCCGAGACCGCCGAGCGCGCCCGGGCGCAGGGCGCCGAGCGCTAG

Upstream 100 bases:

>100_bases
GCTATCGATGACAGATATGCACACCATAAGGCCCTCTGCCCGTCGTCAGCCGCCGCTGAACTCCCCAACGCAAGGTTGCT
CCTGATATGCTCCGGACCCT

Downstream 100 bases:

>100_bases
CCCCATGGCCCCGCGGGCGGCGCCAGACCGCGGTCTCCGCCCCGGCCCGGCGGTATGGCTCGGGCGCTTCCTGCGGGCAG
CGGCGGTCCTGCTGCTGCTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKLYSAKSTFQHDEAPAVGVLVANLGTPDEPTEPALRRYLRQFLSDPRVIEIPRWRWWPILYGIVLRTRPKKSAAAYSEV
WEQDGSPLLSIGQRQAAGIRQRLQALNDRGPFAVELGMRYGNPSIPAALRRLRESGARRILVLPLYPQYSASTTGSTFDA
VARELMGWRWVPELRMVGQYHDEPVYIQALARSIREHWEHEGRGERLLFSYHGVPERYLLDGDPYHCQCLKTSRLVAEEL
GLEPGTWDVTFQSRFGNEEWLKPYTDETVTRLAQEGVKHLDVVCPGFSADCLETLEEIAGENREYFEESGGERLRYIPAL
NDRPDHLEALTALVLQHGQGWREVDGGRDPEAEQRRRAETAERARAQGAER

Sequences:

>Translated_371_residues
MKLYSAKSTFQHDEAPAVGVLVANLGTPDEPTEPALRRYLRQFLSDPRVIEIPRWRWWPILYGIVLRTRPKKSAAAYSEV
WEQDGSPLLSIGQRQAAGIRQRLQALNDRGPFAVELGMRYGNPSIPAALRRLRESGARRILVLPLYPQYSASTTGSTFDA
VARELMGWRWVPELRMVGQYHDEPVYIQALARSIREHWEHEGRGERLLFSYHGVPERYLLDGDPYHCQCLKTSRLVAEEL
GLEPGTWDVTFQSRFGNEEWLKPYTDETVTRLAQEGVKHLDVVCPGFSADCLETLEEIAGENREYFEESGGERLRYIPAL
NDRPDHLEALTALVLQHGQGWREVDGGRDPEAEQRRRAETAERARAQGAER
>Mature_371_residues
MKLYSAKSTFQHDEAPAVGVLVANLGTPDEPTEPALRRYLRQFLSDPRVIEIPRWRWWPILYGIVLRTRPKKSAAAYSEV
WEQDGSPLLSIGQRQAAGIRQRLQALNDRGPFAVELGMRYGNPSIPAALRRLRESGARRILVLPLYPQYSASTTGSTFDA
VARELMGWRWVPELRMVGQYHDEPVYIQALARSIREHWEHEGRGERLLFSYHGVPERYLLDGDPYHCQCLKTSRLVAEEL
GLEPGTWDVTFQSRFGNEEWLKPYTDETVTRLAQEGVKHLDVVCPGFSADCLETLEEIAGENREYFEESGGERLRYIPAL
NDRPDHLEALTALVLQHGQGWREVDGGRDPEAEQRRRAETAERARAQGAER

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=264, Percent_Identity=31.0606060606061, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI60499021, Length=264, Percent_Identity=31.0606060606061, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=47.9495268138801, Blast_Score=295, Evalue=4e-81,
Organism=Drosophila melanogaster, GI17864156, Length=343, Percent_Identity=25.0728862973761, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24651774, Length=266, Percent_Identity=23.6842105263158, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45552018, Length=175, Percent_Identity=27.4285714285714, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 42390; Mature: 42390

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYSAKSTFQHDEAPAVGVLVANLGTPDEPTEPALRRYLRQFLSDPRVIEIPRWRWWPI
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHH
LYGIVLRTRPKKSAAAYSEVWEQDGSPLLSIGQRQAAGIRQRLQALNDRGPFAVELGMRY
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GNPSIPAALRRLRESGARRILVLPLYPQYSASTTGSTFDAVARELMGWRWVPELRMVGQY
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCC
HDEPVYIQALARSIREHWEHEGRGERLLFSYHGVPERYLLDGDPYHCQCLKTSRLVAEEL
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCEEEEHHHHHHHHHHH
GLEPGTWDVTFQSRFGNEEWLKPYTDETVTRLAQEGVKHLDVVCPGFSADCLETLEEIAG
CCCCCCEEEEEHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
ENREYFEESGGERLRYIPALNDRPDHLEALTALVLQHGQGWREVDGGRDPEAEQRRRAET
CCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHH
AERARAQGAER
HHHHHHCCCCC
>Mature Secondary Structure
MKLYSAKSTFQHDEAPAVGVLVANLGTPDEPTEPALRRYLRQFLSDPRVIEIPRWRWWPI
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCHHHHH
LYGIVLRTRPKKSAAAYSEVWEQDGSPLLSIGQRQAAGIRQRLQALNDRGPFAVELGMRY
HHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GNPSIPAALRRLRESGARRILVLPLYPQYSASTTGSTFDAVARELMGWRWVPELRMVGQY
CCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCC
HDEPVYIQALARSIREHWEHEGRGERLLFSYHGVPERYLLDGDPYHCQCLKTSRLVAEEL
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCEEEEHHHHHHHHHHH
GLEPGTWDVTFQSRFGNEEWLKPYTDETVTRLAQEGVKHLDVVCPGFSADCLETLEEIAG
CCCCCCEEEEEHHHCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
ENREYFEESGGERLRYIPALNDRPDHLEALTALVLQHGQGWREVDGGRDPEAEQRRRAET
CCHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHH
AERARAQGAER
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA