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The map label for this gene is serA [H]

Identifier: 121997370

GI number: 121997370

Start: 643957

End: 645126

Strand: Reverse

Name: serA [H]

Synonym: Hhal_0569

Alternate gene names: 121997370

Gene position: 645126-643957 (Counterclockwise)

Preceding gene: 121997371

Following gene: 121997369

Centisome position: 24.09

GC content: 68.03

Gene sequence:

>1170_bases
ATGTACCGCATCCTCACGCTGAACAACATCTCGGTGAAGGGCCTGGATCGGCTGCCGCGCGAACGCTTCGAGACCTCCTC
GGACATCGCGCACCCGGACGCCATCCTGGTGCGCTCCGCCGATCTACACGGCCAGGAGATCCCCGACTCGGTGGTGGCCA
TCGGCCGCGCCGGGGCGGGGGTCAACAACATCCCGGTCGCCGACATGACCGAGCGGGGGGTGCCGGTCTTCAACGCCCCC
GGCGCCAACGCCAATGCGGTCAAGGAGCTGGTCATCGCCGGACTGTTCCTGGCGGCGCGCAACATCTGCCCGGCCTGGGA
GTACGGCCGCGGCCTGCAGGGCAGTGACGCCGAGCTGCACGAGGCCATGGAGGCCAATAAGAAGCGCTTCGTCGGCTTCG
AGCTCCCGGGCCGGACCCTCGGCGTGGTCGGTCTCGGGGCCATCGGCGTCCAGGTGGCCAACACGGCCCGGGCCCTGGGG
ATGAAAGTCGTCGGCTTCGATCCGCAGATCACCGTGGACGCTGCCTGGGCCCTGGACTCCGGCGTCGAGGCGGCGCACAG
CGTCGGCGATGTCATGGCCCGCTCGGACATGATCAGTGTCCACGTGCCGCTGCTCGATGCGACCCGCGGGCTGATCAACG
CCTCGCGCCTGGCGCAGGCCCGGGAGGGGGCCACCCTGCTGAACTTCTCCCGTGCCGAGGTGGTGGACGAGGCCGACGTG
CTCCAGGCGCTCAACGAGGAGCGGCTCCACGCCTACGTCTGCGATTTCCCCAGCAACGCCCTCAAGGACCATCCGCGGGC
GGTGACGCTGCCCCACCTCGGCGCCTCGACCCACGAGGCCCAGGAGAACTGCGCCATCATGGTGGCCGACCAGGTGCGCG
ATTACCTGGAGACCGGCAACGTACGCAATGCGGTCAACTTCCCGGATATGGGCATGCCGCGCAGCGGCAAGGGTGACCGG
CTGTGCGTGGTCAACGCCAATGTGCCGAACATGCTTGGTCAGATCTCCAGCCTGCTGGCGCAGCACGGGTTGAACATCGA
CGACATGTTCAACAAGGCCCAGGAGCAGCTCGCCTATACCCTGGTGGATGTCGAGGGGCAGGTTCCCGACGCGGTGGCCG
AGGAACTGCGCGCCATCGAGGGGGTTCTGAAGGTCCGCGTGATCAGCTGA

Upstream 100 bases:

>100_bases
GTGGCATGCGGGCCTCAATCTACAATGCCATGCCGGAGGCCGGCGTGGACCGGCTCGTCGAGTTCATGGCCGATTTCGAG
AGGCGAAACGGGTGAATCCC

Downstream 100 bases:

>100_bases
GGGGGAGCGATGTCCGTCGACAATGACGACCTCGCCGCGCTGCGGCAACGGATCGACGGGATCGACGACCAGATCCTCGA
GCTGGTCAGTGAGCGGGCCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MYRILTLNNISVKGLDRLPRERFETSSDIAHPDAILVRSADLHGQEIPDSVVAIGRAGAGVNNIPVADMTERGVPVFNAP
GANANAVKELVIAGLFLAARNICPAWEYGRGLQGSDAELHEAMEANKKRFVGFELPGRTLGVVGLGAIGVQVANTARALG
MKVVGFDPQITVDAAWALDSGVEAAHSVGDVMARSDMISVHVPLLDATRGLINASRLAQAREGATLLNFSRAEVVDEADV
LQALNEERLHAYVCDFPSNALKDHPRAVTLPHLGASTHEAQENCAIMVADQVRDYLETGNVRNAVNFPDMGMPRSGKGDR
LCVVNANVPNMLGQISSLLAQHGLNIDDMFNKAQEQLAYTLVDVEGQVPDAVAEELRAIEGVLKVRVIS

Sequences:

>Translated_389_residues
MYRILTLNNISVKGLDRLPRERFETSSDIAHPDAILVRSADLHGQEIPDSVVAIGRAGAGVNNIPVADMTERGVPVFNAP
GANANAVKELVIAGLFLAARNICPAWEYGRGLQGSDAELHEAMEANKKRFVGFELPGRTLGVVGLGAIGVQVANTARALG
MKVVGFDPQITVDAAWALDSGVEAAHSVGDVMARSDMISVHVPLLDATRGLINASRLAQAREGATLLNFSRAEVVDEADV
LQALNEERLHAYVCDFPSNALKDHPRAVTLPHLGASTHEAQENCAIMVADQVRDYLETGNVRNAVNFPDMGMPRSGKGDR
LCVVNANVPNMLGQISSLLAQHGLNIDDMFNKAQEQLAYTLVDVEGQVPDAVAEELRAIEGVLKVRVIS
>Mature_389_residues
MYRILTLNNISVKGLDRLPRERFETSSDIAHPDAILVRSADLHGQEIPDSVVAIGRAGAGVNNIPVADMTERGVPVFNAP
GANANAVKELVIAGLFLAARNICPAWEYGRGLQGSDAELHEAMEANKKRFVGFELPGRTLGVVGLGAIGVQVANTARALG
MKVVGFDPQITVDAAWALDSGVEAAHSVGDVMARSDMISVHVPLLDATRGLINASRLAQAREGATLLNFSRAEVVDEADV
LQALNEERLHAYVCDFPSNALKDHPRAVTLPHLGASTHEAQENCAIMVADQVRDYLETGNVRNAVNFPDMGMPRSGKGDR
LCVVNANVPNMLGQISSLLAQHGLNIDDMFNKAQEQLAYTLVDVEGQVPDAVAEELRAIEGVLKVRVIS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=313, Percent_Identity=31.629392971246, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI145580578, Length=267, Percent_Identity=29.5880149812734, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557499, Length=267, Percent_Identity=29.5880149812734, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI61743967, Length=268, Percent_Identity=29.1044776119403, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4557497, Length=268, Percent_Identity=29.1044776119403, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI145580575, Length=267, Percent_Identity=29.5880149812734, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI6912396, Length=251, Percent_Identity=25.4980079681275, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789279, Length=353, Percent_Identity=30.5949008498584, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787645, Length=191, Percent_Identity=30.3664921465969, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082289, Length=265, Percent_Identity=25.6603773584906, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=273, Percent_Identity=35.5311355311355, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=29.1970802919708, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=367, Percent_Identity=28.0653950953678, Blast_Score=146, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=367, Percent_Identity=27.2479564032698, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=268, Percent_Identity=27.9850746268657, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324964, Length=265, Percent_Identity=25.6603773584906, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=35.5481727574751, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24646446, Length=268, Percent_Identity=29.8507462686567, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646448, Length=268, Percent_Identity=29.8507462686567, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646452, Length=268, Percent_Identity=29.8507462686567, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646450, Length=268, Percent_Identity=29.8507462686567, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI62472511, Length=268, Percent_Identity=29.8507462686567, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI28574286, Length=291, Percent_Identity=25.7731958762887, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45552429, Length=253, Percent_Identity=23.3201581027668, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24585514, Length=253, Percent_Identity=23.3201581027668, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574282, Length=253, Percent_Identity=23.3201581027668, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551003, Length=253, Percent_Identity=23.3201581027668, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28574284, Length=253, Percent_Identity=23.3201581027668, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585516, Length=255, Percent_Identity=22.3529411764706, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 41613; Mature: 41613

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRILTLNNISVKGLDRLPRERFETSSDIAHPDAILVRSADLHGQEIPDSVVAIGRAGAG
CEEEEEECCCCCCCHHHCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCC
VNNIPVADMTERGVPVFNAPGANANAVKELVIAGLFLAARNICPAWEYGRGLQGSDAELH
CCCCCCCCHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHH
EAMEANKKRFVGFELPGRTLGVVGLGAIGVQVANTARALGMKVVGFDPQITVDAAWALDS
HHHHCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCEEEECCCCCEEEEEHHHHHC
GVEAAHSVGDVMARSDMISVHVPLLDATRGLINASRLAQAREGATLLNFSRAEVVDEADV
CHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH
LQALNEERLHAYVCDFPSNALKDHPRAVTLPHLGASTHEAQENCAIMVADQVRDYLETGN
HHHHCHHCEEEEEECCCCHHHHCCCCEEEECCCCCCCHHHCCCCEEEEHHHHHHHHHCCC
VRNAVNFPDMGMPRSGKGDRLCVVNANVPNMLGQISSLLAQHGLNIDDMFNKAQEQLAYT
CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
LVDVEGQVPDAVAEELRAIEGVLKVRVIS
EEECCCCCCHHHHHHHHHHHHHHEEEEEC
>Mature Secondary Structure
MYRILTLNNISVKGLDRLPRERFETSSDIAHPDAILVRSADLHGQEIPDSVVAIGRAGAG
CEEEEEECCCCCCCHHHCCHHHHCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCC
VNNIPVADMTERGVPVFNAPGANANAVKELVIAGLFLAARNICPAWEYGRGLQGSDAELH
CCCCCCCCHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHH
EAMEANKKRFVGFELPGRTLGVVGLGAIGVQVANTARALGMKVVGFDPQITVDAAWALDS
HHHHCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHCEEEECCCCCEEEEEHHHHHC
GVEAAHSVGDVMARSDMISVHVPLLDATRGLINASRLAQAREGATLLNFSRAEVVDEADV
CHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH
LQALNEERLHAYVCDFPSNALKDHPRAVTLPHLGASTHEAQENCAIMVADQVRDYLETGN
HHHHCHHCEEEEEECCCCHHHHCCCCEEEECCCCCCCHHHCCCCEEEEHHHHHHHHHCCC
VRNAVNFPDMGMPRSGKGDRLCVVNANVPNMLGQISSLLAQHGLNIDDMFNKAQEQLAYT
CCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEE
LVDVEGQVPDAVAEELRAIEGVLKVRVIS
EEECCCCCCHHHHHHHHHHHHHHEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]