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The map label for this gene is iciA [H]

Identifier: 121611907

GI number: 121611907

Start: 5561754

End: 5562671

Strand: Direct

Name: iciA [H]

Synonym: Veis_5010

Alternate gene names: 121611907

Gene position: 5561754-5562671 (Clockwise)

Preceding gene: 121611904

Following gene: NA

Centisome position: 99.91

GC content: 69.5

Gene sequence:

>918_bases
ATGAGCAGCTACGATCCCGCCGCGCTGGAATGCCTGGCCGCCATCGTCGAAGAGGGCGGTTTCGAGCGTGCCGCGCAGCG
CCTGAATGTCACGCAGTCGGCGGTGTCGCAGCGCTTGCGTGTGCTGGAGGCCCAGGTAGGCTCGGTGCTGATCGTGCGCA
GCCGGCCGCTGCGGCCCACCCCGGCCGGGCAGTTGCTGCTCAAGCACACCAAGCAGTTGCGGCTGCTGCGCGCCGGCCTG
GAGCGCGACTTGCAAGAGTTGGCCCCGAGCGCCCCCGCTGGCACGCGCGAGGACGAGCGCATCGCGATCGCCATCAACGC
CGACAGCATTGCCACCTGGGCCATGGGCGCGTTGCACGCTCTGGTGCAGCAGCGTCTGCCGCTGGAGATCATCGTCGATG
ACCAGGACTTCACCCAGGAATGGCTGCGCAGCGGCCAGGTGCTCGGCTGCGTGACCACGCTGCGCCAGGCTTTGCGCGGT
TGCAAGATGGTGCCGCTGGGGGCCATGCGTTACGTGGCCGTGGCGGCGACGGGCTACGCGCAGCAGCACCTGCCGCAGGG
GCTGAGCGCCCATAACTTCCGGGCGGTGTCGTTTCTGTCGTTCAACCGCAAGGACGACATGGCCGCCGAGTTCGTGGCGC
GCGCGTTCGGGCTCAGGCGCGTGGCGCTCAATCAATTGTTCGTGCCGGGGTCGGAGGCACAGATGCGCGCCGTGGCCGCA
GGCTGGGCCGTGGGCGTGGTGCCCGAACTACTGGCCCGTGGCCCGGTGGCCGACGGCAGCATGGTCGACCTGGCGCCCGG
CAGGTCGTTGCCGATTGCGCTGTATTGGCATTGCTGGAACCTGGAATCGGCCTTGCTCGATGCGCTGTCTGCGGCGCTGA
CGGGGGCTGCCGCCCAGGCGCTGGTCGCAGCAGCCTGA

Upstream 100 bases:

>100_bases
CAACAGCGGGATTAAACTTCTTCAAAAATCATCAGCACATCTAATACAAACCTAATACAAGCACGCACGCGGCAAGGCTT
GCCGAGCACGTTCAAGGACC

Downstream 100 bases:

>100_bases
CCCCTATTTGCCGATGCAAAAGCGCGCGAAGATGGCCCCGAGCAGGTCGTCGCTGGTGAACGCGCCGGTGATGCTGTCGA
GCGCGTTTTGCGCCAGCCGC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: OriC replication inhibitor [H]

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MSSYDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRVLEAQVGSVLIVRSRPLRPTPAGQLLLKHTKQLRLLRAGL
ERDLQELAPSAPAGTREDERIAIAINADSIATWAMGALHALVQQRLPLEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRG
CKMVPLGAMRYVAVAATGYAQQHLPQGLSAHNFRAVSFLSFNRKDDMAAEFVARAFGLRRVALNQLFVPGSEAQMRAVAA
GWAVGVVPELLARGPVADGSMVDLAPGRSLPIALYWHCWNLESALLDALSAALTGAAAQALVAAA

Sequences:

>Translated_305_residues
MSSYDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRVLEAQVGSVLIVRSRPLRPTPAGQLLLKHTKQLRLLRAGL
ERDLQELAPSAPAGTREDERIAIAINADSIATWAMGALHALVQQRLPLEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRG
CKMVPLGAMRYVAVAATGYAQQHLPQGLSAHNFRAVSFLSFNRKDDMAAEFVARAFGLRRVALNQLFVPGSEAQMRAVAA
GWAVGVVPELLARGPVADGSMVDLAPGRSLPIALYWHCWNLESALLDALSAALTGAAAQALVAAA
>Mature_304_residues
SSYDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRVLEAQVGSVLIVRSRPLRPTPAGQLLLKHTKQLRLLRAGLE
RDLQELAPSAPAGTREDERIAIAINADSIATWAMGALHALVQQRLPLEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGC
KMVPLGAMRYVAVAATGYAQQHLPQGLSAHNFRAVSFLSFNRKDDMAAEFVARAFGLRRVALNQLFVPGSEAQMRAVAAG
WAVGVVPELLARGPVADGSMVDLAPGRSLPIALYWHCWNLESALLDALSAALTGAAAQALVAAA

Specific function: Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=302, Percent_Identity=35.4304635761589, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI1786713, Length=265, Percent_Identity=24.5283018867925, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32716; Mature: 32585

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSYDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRVLEAQVGSVLIVRSRPLRPT
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
PAGQLLLKHTKQLRLLRAGLERDLQELAPSAPAGTREDERIAIAINADSIATWAMGALHA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LVQQRLPLEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGCKMVPLGAMRYVAVAATGYA
HHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QQHLPQGLSAHNFRAVSFLSFNRKDDMAAEFVARAFGLRRVALNQLFVPGSEAQMRAVAA
HHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GWAVGVVPELLARGPVADGSMVDLAPGRSLPIALYWHCWNLESALLDALSAALTGAAAQA
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LVAAA
HHHCC
>Mature Secondary Structure 
SSYDPAALECLAAIVEEGGFERAAQRLNVTQSAVSQRLRVLEAQVGSVLIVRSRPLRPT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
PAGQLLLKHTKQLRLLRAGLERDLQELAPSAPAGTREDERIAIAINADSIATWAMGALHA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHH
LVQQRLPLEIIVDDQDFTQEWLRSGQVLGCVTTLRQALRGCKMVPLGAMRYVAVAATGYA
HHHHCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QQHLPQGLSAHNFRAVSFLSFNRKDDMAAEFVARAFGLRRVALNQLFVPGSEAQMRAVAA
HHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GWAVGVVPELLARGPVADGSMVDLAPGRSLPIALYWHCWNLESALLDALSAALTGAAAQA
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHH
LVAAA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9286976 [H]