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The map label for this gene is serA [C]

Identifier: 121611814

GI number: 121611814

Start: 5435813

End: 5437012

Strand: Direct

Name: serA [C]

Synonym: Veis_4915

Alternate gene names: 121611814

Gene position: 5435813-5437012 (Clockwise)

Preceding gene: 121611812

Following gene: 121611815

Centisome position: 97.65

GC content: 64.08

Gene sequence:

>1200_bases
ATGGCGAAGATCGTTTGCGTGCTGTATGACGACCCCGTAACCGGCGACCCCAAGACCTACGCCCGTGACAGCCTGCCCAG
GCTGGAGCGTTACCCCGATGGCCAGACCCTGCCCACCCCCAGGGCCATCGACTTCCAGCCGGGCACCCTGCTCGGCAGCG
TGTCTGGCGAGTTGGGGCTGCGCAAGTATCTGGAATCCAACGGCCACAAACTGGTCGTGACATCGAGCAAGGACGGCGCC
GATAGCGTGCTGGACCGCGAACTGCACGATGCCGAGATCGTGATTTCCCAGCCCTTCTGGCCCGCCTACATGACCGCCGA
GCGCATCGCCAGGGCGCCCAGGCTGAAGATGATCGTGACGGCAGGCATCGGCTCCGACCACACCGACCTGCAAGCCGCGA
TGGAGCGTGGCGTGACCGTGGCCGAAGTCACTTACTGCAACAGCAACAGCGTGGCCGAGCATGTCGTGATGATGACCTTG
AGCCTGGTGCGCAACTACATCCCCTCGTACAACCGGGTCGTCAAAGGCGGCTGGAACATCGCCGACTGTGTGCAGCGCTC
CTACGACCTCGAAGGCATGCAGGTCGGCAGCGTTGCGGCGGGCCGCATTGGTCTGCGCGTGTTGCGCCTGCTCAAGCCCT
TCGATGTCAAGCTGCATTACCTGGATCGCCATCGCCTGCCGGAAGCCATCGAAAAAGAGCTCCATCTGACGCACCACAGC
AGCCTGGAAAGTCTGACCAAGGTGTGTGACGTGGTCTCGCTGAATTGCCCGCTGCACCCCGAAACCGAGCACATGATCAA
CGCGCAGTCGCTGAAGAACTTCAAACGCGGCGCCTACCTGATCAACACGGCACGCGGCAAGCTGTGCGACCGCGATGCGG
TGGCGGCGGCGCTGGAGAGCGGCCAGCTCGCTGGCTATGCGGGCGACGTGTGGTTCCCGCAACCCGCGCCGAAAGACCAC
CCGTGGCGCAGCATGCCGCACCACGGCATGACGCCGCACATCTCCGGCACCAGCCTGTCGGCGCAAGCACGCTACGCCGC
TGGCACGCGCGAAATCCTGGAGTGCTACTTCGAGAACCGGCCAATCCGTGATGAATACCTGATCGTGCAAGGTGGCAAGC
TGGCTGGCGTTGGCGCGCACTCGTACAGCGCCGGCAACGCGACCAAGGGGTCGGAAGAAGCCGCCCGCTTCAGGAAGTAG

Upstream 100 bases:

>100_bases
TGCCCGAAGGCGAACCATTGGCACCCGAACGGCCCGCGCCGTTCCTGCCAGGCGCCGCCCGGCGCCGCAGCGTTCGAATC
ACTATTTCCGGAGACAAAAC

Downstream 100 bases:

>100_bases
GCTCCGTGCCAGTCTCATCCGCGACGCCCCTCAAGCGGGTCGGCGTGTCGCGGTGCAACCCAGATCGCCAGCATCCTGCT
GGCCGGTTTGGGCGTGTTCC

Product: formate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent formate dehydrogenase; FDH [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MAKIVCVLYDDPVTGDPKTYARDSLPRLERYPDGQTLPTPRAIDFQPGTLLGSVSGELGLRKYLESNGHKLVVTSSKDGA
DSVLDRELHDAEIVISQPFWPAYMTAERIARAPRLKMIVTAGIGSDHTDLQAAMERGVTVAEVTYCNSNSVAEHVVMMTL
SLVRNYIPSYNRVVKGGWNIADCVQRSYDLEGMQVGSVAAGRIGLRVLRLLKPFDVKLHYLDRHRLPEAIEKELHLTHHS
SLESLTKVCDVVSLNCPLHPETEHMINAQSLKNFKRGAYLINTARGKLCDRDAVAAALESGQLAGYAGDVWFPQPAPKDH
PWRSMPHHGMTPHISGTSLSAQARYAAGTREILECYFENRPIRDEYLIVQGGKLAGVGAHSYSAGNATKGSEEAARFRK

Sequences:

>Translated_399_residues
MAKIVCVLYDDPVTGDPKTYARDSLPRLERYPDGQTLPTPRAIDFQPGTLLGSVSGELGLRKYLESNGHKLVVTSSKDGA
DSVLDRELHDAEIVISQPFWPAYMTAERIARAPRLKMIVTAGIGSDHTDLQAAMERGVTVAEVTYCNSNSVAEHVVMMTL
SLVRNYIPSYNRVVKGGWNIADCVQRSYDLEGMQVGSVAAGRIGLRVLRLLKPFDVKLHYLDRHRLPEAIEKELHLTHHS
SLESLTKVCDVVSLNCPLHPETEHMINAQSLKNFKRGAYLINTARGKLCDRDAVAAALESGQLAGYAGDVWFPQPAPKDH
PWRSMPHHGMTPHISGTSLSAQARYAAGTREILECYFENRPIRDEYLIVQGGKLAGVGAHSYSAGNATKGSEEAARFRK
>Mature_398_residues
AKIVCVLYDDPVTGDPKTYARDSLPRLERYPDGQTLPTPRAIDFQPGTLLGSVSGELGLRKYLESNGHKLVVTSSKDGAD
SVLDRELHDAEIVISQPFWPAYMTAERIARAPRLKMIVTAGIGSDHTDLQAAMERGVTVAEVTYCNSNSVAEHVVMMTLS
LVRNYIPSYNRVVKGGWNIADCVQRSYDLEGMQVGSVAAGRIGLRVLRLLKPFDVKLHYLDRHRLPEAIEKELHLTHHSS
LESLTKVCDVVSLNCPLHPETEHMINAQSLKNFKRGAYLINTARGKLCDRDAVAAALESGQLAGYAGDVWFPQPAPKDHP
WRSMPHHGMTPHISGTSLSAQARYAAGTREILECYFENRPIRDEYLIVQGGKLAGVGAHSYSAGNATKGSEEAARFRK

Specific function: Serine biosynthesis; first step. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=284, Percent_Identity=29.9295774647887, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI6912396, Length=233, Percent_Identity=30.4721030042918, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=28.9285714285714, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=28.9285714285714, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=28.2442748091603, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=28.2442748091603, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580575, Length=280, Percent_Identity=28.9285714285714, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789279, Length=247, Percent_Identity=32.3886639676113, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=197, Percent_Identity=31.4720812182741, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI87082289, Length=245, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081824, Length=156, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788660, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=287, Percent_Identity=30.3135888501742, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=238, Percent_Identity=27.3109243697479, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=346, Percent_Identity=48.2658959537572, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324980, Length=211, Percent_Identity=45.4976303317536, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6324979, Length=118, Percent_Identity=57.6271186440678, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6324055, Length=199, Percent_Identity=35.678391959799, Blast_Score=116, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=28.9473684210526, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=266, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=32.1428571428571, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=32.1428571428571, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=32.1428571428571, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=32.1428571428571, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=32.1428571428571, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921140, Length=271, Percent_Identity=30.6273062730627, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28571528, Length=247, Percent_Identity=28.3400809716599, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28574286, Length=228, Percent_Identity=25.8771929824561, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24585514, Length=237, Percent_Identity=26.1603375527426, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574282, Length=237, Percent_Identity=26.1603375527426, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=237, Percent_Identity=26.1603375527426, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=237, Percent_Identity=26.1603375527426, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552429, Length=237, Percent_Identity=26.1603375527426, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585516, Length=232, Percent_Identity=22.8448275862069, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 43971; Mature: 43839

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIVCVLYDDPVTGDPKTYARDSLPRLERYPDGQTLPTPRAIDFQPGTLLGSVSGELGL
CCEEEEEEECCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCEECCCCCCEEECCCCHHHH
RKYLESNGHKLVVTSSKDGADSVLDRELHDAEIVISQPFWPAYMTAERIARAPRLKMIVT
HHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEE
AGIGSDHTDLQAAMERGVTVAEVTYCNSNSVAEHVVMMTLSLVRNYIPSYNRVVKGGWNI
ECCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
ADCVQRSYDLEGMQVGSVAAGRIGLRVLRLLKPFDVKLHYLDRHRLPEAIEKELHLTHHS
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHH
SLESLTKVCDVVSLNCPLHPETEHMINAQSLKNFKRGAYLINTARGKLCDRDAVAAALES
HHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHC
GQLAGYAGDVWFPQPAPKDHPWRSMPHHGMTPHISGTSLSAQARYAAGTREILECYFENR
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCC
PIRDEYLIVQGGKLAGVGAHSYSAGNATKGSEEAARFRK
CCCCCEEEEECCEEEECCCCCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
AKIVCVLYDDPVTGDPKTYARDSLPRLERYPDGQTLPTPRAIDFQPGTLLGSVSGELGL
CEEEEEEECCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCEECCCCCCEEECCCCHHHH
RKYLESNGHKLVVTSSKDGADSVLDRELHDAEIVISQPFWPAYMTAERIARAPRLKMIVT
HHHHHCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEE
AGIGSDHTDLQAAMERGVTVAEVTYCNSNSVAEHVVMMTLSLVRNYIPSYNRVVKGGWNI
ECCCCCHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCH
ADCVQRSYDLEGMQVGSVAAGRIGLRVLRLLKPFDVKLHYLDRHRLPEAIEKELHLTHHS
HHHHHHHCCCCCEEECCCHHHHHHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHHHHHH
SLESLTKVCDVVSLNCPLHPETEHMINAQSLKNFKRGAYLINTARGKLCDRDAVAAALES
HHHHHHHHHHHHCCCCCCCCCHHHHHCHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHC
GQLAGYAGDVWFPQPAPKDHPWRSMPHHGMTPHISGTSLSAQARYAAGTREILECYFENR
CCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCC
PIRDEYLIVQGGKLAGVGAHSYSAGNATKGSEEAARFRK
CCCCCEEEEECCEEEECCCCCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1954846; 2357236; 1597184; 8484798 [H]