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The map label for this gene is serA [H]

Identifier: 121611812

GI number: 121611812

Start: 5432808

End: 5433815

Strand: Direct

Name: serA [H]

Synonym: Veis_4913

Alternate gene names: 121611812

Gene position: 5432808-5433815 (Clockwise)

Preceding gene: 121611811

Following gene: 121611814

Centisome position: 97.59

GC content: 62.2

Gene sequence:

>1008_bases
ATGAATATTGTGATTCTCGACGACTACCAGGACGCGGTGCGCAAACTGCATTGCGCCTCCCGGCTCGATGCGTACACCGC
CAAGGTCTACACCAACACGGTCAAAGGGCTGGGCCAGCTCTCCGTGCGCCTGAGGGATGCCGACATCATCGTGCTGATCA
GGGAACGCTCCCAGATCACGCGCCAACTGGTCGAAAAGCTCCCACGGCTCAAGCTCATTGCGCAAACCGGCAAGATCGCA
GGCCATGTCGATGTCGCTGCCTGCACCGAGCGCGGCATTGCCGTGGCAGAAGGCGTGGGCTCCCCGGTGGCCCCGGCAGA
ACTGACCTGGACCCTGGTCATGGCGGCCATGCGCAGGCTACCGCAGTACATCGCCAATCTCAAGCATGGCGCCTGGCAGC
AGTCGGGCCTGAAGAGCGCGTCCATGCCCACCAACTTCGGCATTGGCAGCGTGCTGCGCGGCAAGACGCTGGGAATCTGG
GGCTACGGCCGCGTTGGTCAGATCGTGGCCGGTTATGGCCGGGCGTTTGGCATGAATGTGCGTATCTGGGGCCGTGAGCC
CTCACGCGCGCAAGCGTTGACGGATGGCTACCAGGCGGCCAGCACACGCGAGGAGTTCTTCTCCCAGTGCGATGTCATCT
CGCTGCACCTGCGGCTGAGCGACGAGACGCAGGGCATCATCTCGCTGGAGGATCTTTCGTGCATGAAAACCACATCGTTG
CTGATCAATACATCGCGCGCCGAACTGATCAAGCCCGACGTACTGATCGCCGCACTGAATCGCGGCCGCCCCGGCATGGC
CGCCGTTGACGTGTTCGAGAGCGAGCCCATCATGCAAGGCCATGCCCTCTTGCGGCTCGAAAACTGCATCTGCACGCCGC
ACATCGGCTATGTCGAGCAAGACAGCTACGAACTGTACTTTGGCGCGGCATTCGACAACGTGGTGAACTTCATCAAGGGC
ACCCCGACCAATATCGTGAACCCGGGCGCGCTGCAGGTGCGGCGTTGA

Upstream 100 bases:

>100_bases
GGCCGGCTGGCCGCTGCCCAGGCGCTACAGGCTCGATGTCGGCCGCGCCAAGCGGGCCTCTGACGCGCTACGGCTGGCCG
CGCCAAGGCACAATGGCGGG

Downstream 100 bases:

>100_bases
AGCCCCCGAAGCACCTTCACCTTCGGCGCGGCGCCCGGGTTCTTGGGTCCATCGGGGGGATGGTGACGGCGATTCTGATG
CAGCGGTCATCGGGCGCAGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNIVILDDYQDAVRKLHCASRLDAYTAKVYTNTVKGLGQLSVRLRDADIIVLIRERSQITRQLVEKLPRLKLIAQTGKIA
GHVDVAACTERGIAVAEGVGSPVAPAELTWTLVMAAMRRLPQYIANLKHGAWQQSGLKSASMPTNFGIGSVLRGKTLGIW
GYGRVGQIVAGYGRAFGMNVRIWGREPSRAQALTDGYQAASTREEFFSQCDVISLHLRLSDETQGIISLEDLSCMKTTSL
LINTSRAELIKPDVLIAALNRGRPGMAAVDVFESEPIMQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR

Sequences:

>Translated_335_residues
MNIVILDDYQDAVRKLHCASRLDAYTAKVYTNTVKGLGQLSVRLRDADIIVLIRERSQITRQLVEKLPRLKLIAQTGKIA
GHVDVAACTERGIAVAEGVGSPVAPAELTWTLVMAAMRRLPQYIANLKHGAWQQSGLKSASMPTNFGIGSVLRGKTLGIW
GYGRVGQIVAGYGRAFGMNVRIWGREPSRAQALTDGYQAASTREEFFSQCDVISLHLRLSDETQGIISLEDLSCMKTTSL
LINTSRAELIKPDVLIAALNRGRPGMAAVDVFESEPIMQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR
>Mature_335_residues
MNIVILDDYQDAVRKLHCASRLDAYTAKVYTNTVKGLGQLSVRLRDADIIVLIRERSQITRQLVEKLPRLKLIAQTGKIA
GHVDVAACTERGIAVAEGVGSPVAPAELTWTLVMAAMRRLPQYIANLKHGAWQQSGLKSASMPTNFGIGSVLRGKTLGIW
GYGRVGQIVAGYGRAFGMNVRIWGREPSRAQALTDGYQAASTREEFFSQCDVISLHLRLSDETQGIISLEDLSCMKTTSL
LINTSRAELIKPDVLIAALNRGRPGMAAVDVFESEPIMQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVVNFIKG
TPTNIVNPGALQVRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=296, Percent_Identity=28.7162162162162, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI61743967, Length=255, Percent_Identity=32.156862745098, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4557497, Length=255, Percent_Identity=32.156862745098, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=31.1284046692607, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI145580578, Length=294, Percent_Identity=29.9319727891156, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557499, Length=294, Percent_Identity=29.9319727891156, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=31.9066147859922, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI87082289, Length=286, Percent_Identity=28.6713286713287, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789279, Length=300, Percent_Identity=29.3333333333333, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787645, Length=285, Percent_Identity=27.3684210526316, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081824, Length=146, Percent_Identity=32.8767123287671, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=336, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=31.5175097276265, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=28.4615384615385, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322116, Length=312, Percent_Identity=25.9615384615385, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=226, Percent_Identity=28.7610619469027, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=23.7037037037037, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646446, Length=247, Percent_Identity=31.9838056680162, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646448, Length=247, Percent_Identity=31.9838056680162, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646452, Length=247, Percent_Identity=31.9838056680162, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24646450, Length=247, Percent_Identity=31.9838056680162, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI62472511, Length=247, Percent_Identity=31.9838056680162, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=27.6264591439689, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=25.3846153846154, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=25.3846153846154, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=25.3846153846154, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=25.3846153846154, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=25.3846153846154, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921140, Length=292, Percent_Identity=28.0821917808219, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571528, Length=239, Percent_Identity=27.6150627615063, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585516, Length=244, Percent_Identity=25.4098360655738, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 36713; Mature: 36713

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVILDDYQDAVRKLHCASRLDAYTAKVYTNTVKGLGQLSVRLRDADIIVLIRERSQIT
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECHHHHH
RQLVEKLPRLKLIAQTGKIAGHVDVAACTERGIAVAEGVGSPVAPAELTWTLVMAAMRRL
HHHHHHCCCEEEEHHCCCCCCCEEHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHH
PQYIANLKHGAWQQSGLKSASMPTNFGIGSVLRGKTLGIWGYGRVGQIVAGYGRAFGMNV
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHCCHHEECEE
RIWGREPSRAQALTDGYQAASTREEFFSQCDVISLHLRLSDETQGIISLEDLSCMKTTSL
EEECCCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCHHHHHHHH
LINTSRAELIKPDVLIAALNRGRPGMAAVDVFESEPIMQGHALLRLENCICTPHIGYVEQ
EEECCHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHEEECCEECCCCCCCEEC
DSYELYFGAAFDNVVNFIKGTPTNIVNPGALQVRR
CCEEEEEECHHHHHHHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MNIVILDDYQDAVRKLHCASRLDAYTAKVYTNTVKGLGQLSVRLRDADIIVLIRERSQIT
CEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECHHHHH
RQLVEKLPRLKLIAQTGKIAGHVDVAACTERGIAVAEGVGSPVAPAELTWTLVMAAMRRL
HHHHHHCCCEEEEHHCCCCCCCEEHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHH
PQYIANLKHGAWQQSGLKSASMPTNFGIGSVLRGKTLGIWGYGRVGQIVAGYGRAFGMNV
HHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHCCHHEECEE
RIWGREPSRAQALTDGYQAASTREEFFSQCDVISLHLRLSDETQGIISLEDLSCMKTTSL
EEECCCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEECCCHHHHHHHH
LINTSRAELIKPDVLIAALNRGRPGMAAVDVFESEPIMQGHALLRLENCICTPHIGYVEQ
EEECCHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHEEECCEECCCCCCCEEC
DSYELYFGAAFDNVVNFIKGTPTNIVNPGALQVRR
CCEEEEEECHHHHHHHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]