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The map label for this gene is lysA [H]

Identifier: 121611670

GI number: 121611670

Start: 5260539

End: 5261783

Strand: Direct

Name: lysA [H]

Synonym: Veis_4766

Alternate gene names: 121611670

Gene position: 5260539-5261783 (Clockwise)

Preceding gene: 121611669

Following gene: 121611671

Centisome position: 94.5

GC content: 70.12

Gene sequence:

>1245_bases
ATGTCCAGTCTGTTCTCGCCCGCCCAATGCTGGTCTTTGGCCGACCGGTTCGCAACCCCGCTGTGGGTGTATGACGCAGC
CACCATCGTCGAGCGCATCGCCCGGCTGTCCCGGTTCGACACCATCCGCTTTGCGCAAAAAGCCTGCTCGAACATCCACA
TCCTTGCGCTGATGCGCGCGCAGGGCGTGCTGGTCGATGCGGTCTCGCGCGGCGAGATCCTGCGGGCGCTGGCCGCCGGC
TACCAGACCGGCGCCCAGCCCGCGCAGATCGTCTTCACCGCCGACCTGTTCGACGCCGCCACGCTGGCCTGCGTCATCGA
GCATCGCGTGCCGGTGAACGCCGGCTCGATGGACATGCTGCACCAGCTAGGCCCGCGCTCGCCCGGCCACGCGGTATGGC
TGCGCATCAACCCCGGCTTTGGCCATGGCCACAGCCACAAGACCAACACCGGCGGCGAACACAGCAAGCACGGCATCTGG
CACACCGACCTGCCGGCCGCGCTCGCCGCCATCAGGCAGCATGGCCTGGACCTGGTGGGCCTGCACATGCATATCGGCTC
GGGCGTGGACTACCGCCACCTGGCGCAGGTCTGCGACGCCATGGTGGCGCTGGTGCGCGGCGTGCGCGCGGCAGGGCATG
ATCTGCGGGCGATATCGGCCGGCGGCGGCCTGTCTGTCCCGTACCGCAGCGGCGACCCGGTGGTCGACACGGCGCATTAC
CACGGCCTGTGGGAAGCGGCGCGCCAGCAGGCCCAGGCCATCATCGGCCACCCGCTGACGCTGGAGATCGAGCCGGGCCG
CTATTTGGTGGCCGAATCGGGCGTGCTGCTCGCTGCGGTGTGCGCGACCAAGCAGGTGGGCAGCAACCACTTCGTGCTGC
TCGACGCGGGCTTCAATGAACTGCTGCGCCCCTCGATGTACGGCAGCTACCACGCGATGAGCCTGCTGCGGCGCGACGGC
GCCAGCGCCGCCGGGCGCCCCACCGTGGTGGCCGGCCCGCTGTGCGAAGCGGGCGACGTATTCACGCAAAGCGGCGACGG
CCTGGTGCTGCCACGCGACCTGCCCCCCGCCGAGGTGGGCGACCTGCTGCTCATCCATGACACCGGGGCCTACGGCGCGA
CCATGTCCTCCAACTACAACACCCGCCCCCTGAGCGCCGAAGCGCTGGTCGAAGGCGCCCAGGCCCGGCTCATCCGCCGC
CGCCAGACGGTCGACGAACTGCTGGCGCTGGAACGGGGGCTTTGA

Upstream 100 bases:

>100_bases
GCGCTCGGCGGCGAGGTGCACAAGTTCGTCTCGCCAGCCGTGCAGGAACGCCTGCAAGCCAAAGTACGCAGCCAGGCAGC
GCAGGAGTGATGTTTGCCCC

Downstream 100 bases:

>100_bases
GCACCCCCTCGAGCATCCCTTTGCGCGCCCGTTCCAGGCCCGCGCCACCACGTTGGACACAGCGGCGCAGGCCAGCGCGC
ACCACGGTGGGCTGGCCGAC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSSLFSPAQCWSLADRFATPLWVYDAATIVERIARLSRFDTIRFAQKACSNIHILALMRAQGVLVDAVSRGEILRALAAG
YQTGAQPAQIVFTADLFDAATLACVIEHRVPVNAGSMDMLHQLGPRSPGHAVWLRINPGFGHGHSHKTNTGGEHSKHGIW
HTDLPAALAAIRQHGLDLVGLHMHIGSGVDYRHLAQVCDAMVALVRGVRAAGHDLRAISAGGGLSVPYRSGDPVVDTAHY
HGLWEAARQQAQAIIGHPLTLEIEPGRYLVAESGVLLAAVCATKQVGSNHFVLLDAGFNELLRPSMYGSYHAMSLLRRDG
ASAAGRPTVVAGPLCEAGDVFTQSGDGLVLPRDLPPAEVGDLLLIHDTGAYGATMSSNYNTRPLSAEALVEGAQARLIRR
RQTVDELLALERGL

Sequences:

>Translated_414_residues
MSSLFSPAQCWSLADRFATPLWVYDAATIVERIARLSRFDTIRFAQKACSNIHILALMRAQGVLVDAVSRGEILRALAAG
YQTGAQPAQIVFTADLFDAATLACVIEHRVPVNAGSMDMLHQLGPRSPGHAVWLRINPGFGHGHSHKTNTGGEHSKHGIW
HTDLPAALAAIRQHGLDLVGLHMHIGSGVDYRHLAQVCDAMVALVRGVRAAGHDLRAISAGGGLSVPYRSGDPVVDTAHY
HGLWEAARQQAQAIIGHPLTLEIEPGRYLVAESGVLLAAVCATKQVGSNHFVLLDAGFNELLRPSMYGSYHAMSLLRRDG
ASAAGRPTVVAGPLCEAGDVFTQSGDGLVLPRDLPPAEVGDLLLIHDTGAYGATMSSNYNTRPLSAEALVEGAQARLIRR
RQTVDELLALERGL
>Mature_413_residues
SSLFSPAQCWSLADRFATPLWVYDAATIVERIARLSRFDTIRFAQKACSNIHILALMRAQGVLVDAVSRGEILRALAAGY
QTGAQPAQIVFTADLFDAATLACVIEHRVPVNAGSMDMLHQLGPRSPGHAVWLRINPGFGHGHSHKTNTGGEHSKHGIWH
TDLPAALAAIRQHGLDLVGLHMHIGSGVDYRHLAQVCDAMVALVRGVRAAGHDLRAISAGGGLSVPYRSGDPVVDTAHYH
GLWEAARQQAQAIIGHPLTLEIEPGRYLVAESGVLLAAVCATKQVGSNHFVLLDAGFNELLRPSMYGSYHAMSLLRRDGA
SAAGRPTVVAGPLCEAGDVFTQSGDGLVLPRDLPPAEVGDLLLIHDTGAYGATMSSNYNTRPLSAEALVEGAQARLIRRR
QTVDELLALERGL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=395, Percent_Identity=66.0759493670886, Blast_Score=520, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44250; Mature: 44119

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLFSPAQCWSLADRFATPLWVYDAATIVERIARLSRFDTIRFAQKACSNIHILALMRA
CCCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHH
QGVLVDAVSRGEILRALAAGYQTGAQPAQIVFTADLFDAATLACVIEHRVPVNAGSMDML
CCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHH
HQLGPRSPGHAVWLRINPGFGHGHSHKTNTGGEHSKHGIWHTDLPAALAAIRQHGLDLVG
HHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LHMHIGSGVDYRHLAQVCDAMVALVRGVRAAGHDLRAISAGGGLSVPYRSGDPVVDTAHY
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECHHH
HGLWEAARQQAQAIIGHPLTLEIEPGRYLVAESGVLLAAVCATKQVGSNHFVLLDAGFNE
HHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEHHHHHHHCCCCCEEEEECCHHH
LLRPSMYGSYHAMSLLRRDGASAAGRPTVVAGPLCEAGDVFTQSGDGLVLPRDLPPAEVG
HHCCHHCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEECCCCCEEECCCCCCCCCC
DLLLIHDTGAYGATMSSNYNTRPLSAEALVEGAQARLIRRRQTVDELLALERGL
CEEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSLFSPAQCWSLADRFATPLWVYDAATIVERIARLSRFDTIRFAQKACSNIHILALMRA
CCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHH
QGVLVDAVSRGEILRALAAGYQTGAQPAQIVFTADLFDAATLACVIEHRVPVNAGSMDML
CCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHH
HQLGPRSPGHAVWLRINPGFGHGHSHKTNTGGEHSKHGIWHTDLPAALAAIRQHGLDLVG
HHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LHMHIGSGVDYRHLAQVCDAMVALVRGVRAAGHDLRAISAGGGLSVPYRSGDPVVDTAHY
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECHHH
HGLWEAARQQAQAIIGHPLTLEIEPGRYLVAESGVLLAAVCATKQVGSNHFVLLDAGFNE
HHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEHHHHHHHCCCCCEEEEECCHHH
LLRPSMYGSYHAMSLLRRDGASAAGRPTVVAGPLCEAGDVFTQSGDGLVLPRDLPPAEVG
HHCCHHCCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCEECCCCCEEECCCCCCCCCC
DLLLIHDTGAYGATMSSNYNTRPLSAEALVEGAQARLIRRRQTVDELLALERGL
CEEEEEECCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]