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The map label for this gene is lrp [H]

Identifier: 121611357

GI number: 121611357

Start: 4910018

End: 4910491

Strand: Direct

Name: lrp [H]

Synonym: Veis_4443

Alternate gene names: 121611357

Gene position: 4910018-4910491 (Clockwise)

Preceding gene: 121611355

Following gene: 121611358

Centisome position: 88.2

GC content: 65.82

Gene sequence:

>474_bases
ATGAGCAAACCCACCGACCTGGACCGGATCGACCGCAAGATCCTGTCCATCCTGCAAGAAGACGGCCGCATCGCCAACCT
CAAGCTGGCCGAGGCCGTGGCCCTGTCGCCCACGGCCGTGCTGGCGCGCGTGCAGCGCCTGGCGCGCGCGGGCATCATCG
AAGGCTATTCAGCGCGGCTGAACCCCTCGATGCTGGGCGCGGGCATGCTGGTGTTCGTCGAGGTGCTGCTGGACCGCACC
ACGCCGAATGTGTTCGAGCAGTTCAAAGCCGCCGTGCAGGTGCACCCCGAGATCATGGAATGCCACATGGTGGCGGGCGG
GTTCGACTACCTGCTCAAGACCCGCTCTGCCGACATGAACGCCTACCGCCTGTTCGCCGGCGCGGTGCTCTGGCAACTGC
CGGGTGTGCGCGAGACGCGCACTTATGCGGTGATGGAAGAGGTCAAGCACAGCAGCCATTTGCCGCTGCGCTGA

Upstream 100 bases:

>100_bases
GCATGGCGGTCTTTCGGTAAGCCCGATGCGATGATCCCTGGACTTGCGCCGAATGAATGGCTGAAAATCACCGGCCGCAT
AGAGAAATTCACCAGTTTCG

Downstream 100 bases:

>100_bases
GGGGTCGGGGAGACTGAGCGGCCGATCGGCGCCCCAGTCGGCGCAGTGCTCCCCGATCGAGGCGACGACCTGCGCCAGCA
CATCGCCTGATGTTCGCCGA

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MSKPTDLDRIDRKILSILQEDGRIANLKLAEAVALSPTAVLARVQRLARAGIIEGYSARLNPSMLGAGMLVFVEVLLDRT
TPNVFEQFKAAVQVHPEIMECHMVAGGFDYLLKTRSADMNAYRLFAGAVLWQLPGVRETRTYAVMEEVKHSSHLPLR

Sequences:

>Translated_157_residues
MSKPTDLDRIDRKILSILQEDGRIANLKLAEAVALSPTAVLARVQRLARAGIIEGYSARLNPSMLGAGMLVFVEVLLDRT
TPNVFEQFKAAVQVHPEIMECHMVAGGFDYLLKTRSADMNAYRLFAGAVLWQLPGVRETRTYAVMEEVKHSSHLPLR
>Mature_156_residues
SKPTDLDRIDRKILSILQEDGRIANLKLAEAVALSPTAVLARVQRLARAGIIEGYSARLNPSMLGAGMLVFVEVLLDRTT
PNVFEQFKAAVQVHPEIMECHMVAGGFDYLLKTRSADMNAYRLFAGAVLWQLPGVRETRTYAVMEEVKHSSHLPLR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=152, Percent_Identity=60.5263157894737, Blast_Score=192, Evalue=1e-50,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34, Blast_Score=99, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17477; Mature: 17345

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPTDLDRIDRKILSILQEDGRIANLKLAEAVALSPTAVLARVQRLARAGIIEGYSARL
CCCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
NPSMLGAGMLVFVEVLLDRTTPNVFEQFKAAVQVHPEIMECHMVAGGFDYLLKTRSADMN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCCCCCH
AYRLFAGAVLWQLPGVRETRTYAVMEEVKHSSHLPLR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKPTDLDRIDRKILSILQEDGRIANLKLAEAVALSPTAVLARVQRLARAGIIEGYSARL
CCCCCHHHHHHHHHHHHHHCCCEECHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCC
NPSMLGAGMLVFVEVLLDRTTPNVFEQFKAAVQVHPEIMECHMVAGGFDYLLKTRSADMN
CHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCCCCCH
AYRLFAGAVLWQLPGVRETRTYAVMEEVKHSSHLPLR
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]