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The map label for this gene is glyA [H]

Identifier: 121611162

GI number: 121611162

Start: 4684477

End: 4685793

Strand: Direct

Name: glyA [H]

Synonym: Veis_4246

Alternate gene names: 121611162

Gene position: 4684477-4685793 (Clockwise)

Preceding gene: 121611161

Following gene: 121611163

Centisome position: 84.15

GC content: 64.62

Gene sequence:

>1317_bases
ATGGTTTCCTTTTGCGTTCCGCCGTTCGCCGGGGCAGCCCTGTTGCAAGGGACACCAGTTCATAAGCCTGTCATGTACCA
CCGCCATCTTCTCGTCGAGCAAACCGACCCTGAGCTCTTTGCCGCCATCGAGGCTGAAAACGCCCGGCAAGAGCAACACA
TCGAACTGATCGCCAGCGAAAACTACGCCTCGCCGGCGGTCATGTGGGCCCAGGGCACACAGTTGACCAACAAGTACGCC
GAGGGCTATCCCGGCAAGCGCTACTACGGTGGTTGCGAGCATGTGGATGTGGCCGAGCAACTGGCCATCGACCGCGTCAA
GAAACTCTTTGGCGCCGAGGCCGCCAATGTCCAGCCCCATTGCGGCGCCTCAGCCAACGAGGCCGTGTTCCTGGCCTTCC
TCAAGCCCGGCGACACCATCATGGGCATGAGCCTGGCCGAGGGCGGCCATCTGACGCATGGCATGTCGCTGAACATGTCC
GGCAAGTGGTTCAATGCGGTCTCCTACGGCCTCGACGCCGATGAGGTGATCGACTACGAGGCGATGGAGAAAAAGGCCCA
TGCGACCCGGCCCCGCCTGATCATTGCCGGCGCGTCGGCATACAGCCTGCATATCGACTTTGCCCGCTTTGCCCAGGTGG
CCAAGGACGTGGGCGCGATCTTCATGGTCGACATGGCCCATTACGCCGGCCTGATTGCCGCCGGCCTGTACCCCAATCCG
GTGCCCCACGCCGATGTGGTCACCAGCACCACCCACAAGAGCCTGCGCGGCCCCCGTGGCGGCATCATCCTGATGCGGGC
CGCGCATGAAAAAGCCATCCACAGCGCCATCTTCCCGGGCCTGCAAGGCGGCCCGCTGATGCATGTGATCGCGGCCAAGG
CGGTGGCTTTCCAGGAAGCGCTGCAGCCCGGGTTCAGGCTGTACCAGGAGCAGGTGCTCAAAAATGCCAAGGTGCTGGCC
CAGACGCTGGCCGCGCGCGGCCTGCGCATCGTCAGCGGCGGCACGCAAAGCCACATGATGCTGGTGGACCTGCGCGCCAA
GGGCATCACCGGCAAGGAGGCCGAAGCCGTGCTGGGCGCCGCCCACATGACCATCAACAAGAACGCGATCCCCAACGACC
CGGAAAAGCCGATGGTGACCAGCGGCGTGCGCATTGGCACCCCCGCAATGACCACGCGCGGCTTCAAGGAAGAACAGGCA
CGCAGCACGGCCGAGTTGATCGCCGACCTGCTGGACAAGCCGCGCGACGCGGCCAACATCGCTGCGGTGCGCGCCAAGGT
CGACGCGCTGACGGCCCGCTTTCCGGTCTACGGCTGA

Upstream 100 bases:

>100_bases
CGCTGCCCCCGCATATGAGCAAGGGCGCAGCCGCTGACGTGGAACCAGCAAGGGCTTTGCCGCTTGTGCAACGAACCACC
GGGGAGCGTGCCGCAAGGGG

Downstream 100 bases:

>100_bases
TGGCGCTCTGCGTCCGGCCGCCCGATGAAGCCGCCATGAAGCCGCCATGAAATGCCCCTTTTGCAGCCACCTCGAAACCC
AGGTCATCGAAACCCGGGTC

Product: glycine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MVSFCVPPFAGAALLQGTPVHKPVMYHRHLLVEQTDPELFAAIEAENARQEQHIELIASENYASPAVMWAQGTQLTNKYA
EGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMS
GKWFNAVSYGLDADEVIDYEAMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNP
VPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEALQPGFRLYQEQVLKNAKVLA
QTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGAAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQA
RSTAELIADLLDKPRDAANIAAVRAKVDALTARFPVYG

Sequences:

>Translated_438_residues
MVSFCVPPFAGAALLQGTPVHKPVMYHRHLLVEQTDPELFAAIEAENARQEQHIELIASENYASPAVMWAQGTQLTNKYA
EGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMS
GKWFNAVSYGLDADEVIDYEAMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNP
VPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEALQPGFRLYQEQVLKNAKVLA
QTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGAAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQA
RSTAELIADLLDKPRDAANIAAVRAKVDALTARFPVYG
>Mature_438_residues
MVSFCVPPFAGAALLQGTPVHKPVMYHRHLLVEQTDPELFAAIEAENARQEQHIELIASENYASPAVMWAQGTQLTNKYA
EGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMS
GKWFNAVSYGLDADEVIDYEAMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNP
VPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEALQPGFRLYQEQVLKNAKVLA
QTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGAAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQA
RSTAELIADLLDKPRDAANIAAVRAKVDALTARFPVYG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=453, Percent_Identity=42.3841059602649, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862352, Length=453, Percent_Identity=42.3841059602649, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862350, Length=453, Percent_Identity=42.3841059602649, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862348, Length=453, Percent_Identity=42.3841059602649, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=41.8141592920354, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=428, Percent_Identity=41.1214953271028, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI22547189, Length=440, Percent_Identity=37.7272727272727, Blast_Score=278, Evalue=8e-75,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=59.375, Blast_Score=506, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=45.75, Blast_Score=350, Evalue=9e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=45.75, Blast_Score=350, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=44.139650872818, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=441, Percent_Identity=43.5374149659864, Blast_Score=340, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24640005, Length=412, Percent_Identity=44.6601941747573, Blast_Score=352, Evalue=3e-97,
Organism=Drosophila melanogaster, GI221329721, Length=412, Percent_Identity=44.6601941747573, Blast_Score=352, Evalue=4e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 47019; Mature: 47019

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFCVPPFAGAALLQGTPVHKPVMYHRHLLVEQTDPELFAAIEAENARQEQHIELIASE
CCCEECCCCCCHHHHCCCCCCCHHHHHHHEEEECCCCCEEEEEECCCCCHHHHEEEEECC
NYASPAVMWAQGTQLTNKYAEGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPH
CCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
CGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMSGKWFNAVSYGLDADEVIDYE
CCCCCCCEEEEEEECCCCEEEEEEECCCCCEECCEEECCCCCCHHHHHCCCCHHHHHCHH
AMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNP
HHHHHHHCCCCEEEEEECCEEEEEECHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCC
VPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEA
CCCCHHEECCHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LQPGFRLYQEQVLKNAKVLAQTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHH
AHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQARSTAELIADLLDKPRDAANI
EEEEECCCCCCCCCCCCCEECCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
AAVRAKVDALTARFPVYG
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSFCVPPFAGAALLQGTPVHKPVMYHRHLLVEQTDPELFAAIEAENARQEQHIELIASE
CCCEECCCCCCHHHHCCCCCCCHHHHHHHEEEECCCCCEEEEEECCCCCHHHHEEEEECC
NYASPAVMWAQGTQLTNKYAEGYPGKRYYGGCEHVDVAEQLAIDRVKKLFGAEAANVQPH
CCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
CGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMSLNMSGKWFNAVSYGLDADEVIDYE
CCCCCCCEEEEEEECCCCEEEEEEECCCCCEECCEEECCCCCCHHHHHCCCCHHHHHCHH
AMEKKAHATRPRLIIAGASAYSLHIDFARFAQVAKDVGAIFMVDMAHYAGLIAAGLYPNP
HHHHHHHCCCCEEEEEECCEEEEEECHHHHHHHHHHHHHEEEHHHHHHHHHHHHCCCCCC
VPHADVVTSTTHKSLRGPRGGIILMRAAHEKAIHSAIFPGLQGGPLMHVIAAKAVAFQEA
CCCCHHEECCHHHHHCCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LQPGFRLYQEQVLKNAKVLAQTLAARGLRIVSGGTQSHMMLVDLRAKGITGKEAEAVLGA
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHH
AHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKEEQARSTAELIADLLDKPRDAANI
EEEEECCCCCCCCCCCCCEECCEEECCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHH
AAVRAKVDALTARFPVYG
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA