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The map label for this gene is yngE [H]

Identifier: 121611160

GI number: 121611160

Start: 4682490

End: 4684097

Strand: Direct

Name: yngE [H]

Synonym: Veis_4244

Alternate gene names: 121611160

Gene position: 4682490-4684097 (Clockwise)

Preceding gene: 121611159

Following gene: 121611161

Centisome position: 84.12

GC content: 65.42

Gene sequence:

>1608_bases
ATGACCATTCTCGACACCCGACTGAACATCCGCTCGGCCGATTTTCTGGCCAACGCTGCTGCCATGCGCACGCTGGTGGA
CGGGCTGCGTGCCCAACTCGACAAGGTTGCCCAAGGTGGCGGCGAGGCGGCACGGGCCAAGCATGTGGCGCGGGGCAAGT
TGCTGCCGCGCGAGCGCGTGCAAATGCTGCTGGACCCCGGCACGCCGTTCCTGGAACTGGCGCCGCTGGCCGCGCTCGAC
ATGTACGACAACGATGCGCCCGGCGCGGGTCTGATCACCGGCATTGGCCGCGTCAGCGGCGTCGACTGCATGGTGGTGTG
CAACGATGCCACGGTCAAAGGCGGCACCTACTACCCGCTGACCGTCAAGAAGCATCTGCGGGCGCAGGAGGTGGCGCAGC
AAAACCACCTGCCCTGCATCTACCTGGTCGATTCCGGGGGCGCGAACCTGCCCAACCAGGACGAGGTCTTTCCCGACCGC
GACCACTTCGGCCGCATCTTCTTCAACCAGGCCCAAATGAGCGCCATGGGCATCGCGCAGATTGCCGTGGTCATGGGCAG
TTGCACGGCGGGCGGCGCCTATGTGCCGGCGATGAGCGACGAGTCGATCATCGTCCAGAACCAGGGCACGATCTTTCTCG
GCGGGCCGCCGCTGGTCAAAGCCGCCACGGGCGAGATCGTCACGGCCGAGGACCTGGGCGGTGGCGATGTGCACACCCGC
TTGTCGGGTGTGGCCGATCACCTGGCGCTCAGCGACATGCACGCGCTGCAACTGGCCCGCAATGCGCTGCGCAACCTGAA
TAAAAACAACGCGCAGGCGCAAGTCGATCATGCGCCTTGCGCTCCGAAATATGCAGCACAGGAACTGTATGGCGTGATTC
CGGCGGACCCGCGCAAGACCTTCGACGTGCGCGAGATCATCGCCCGCATCGTCGATGGCAGCGAGTTCGACGAATTCAAG
GCCCGTTACGGCACCACGCTGGTCACGGGCTTTGCGCGCATCGAGGGCATGGCGGTGGGCATCATCGCCAACAATGGCAT
CCTGTTTTCCGAAAGCGCGCTCAAGGGCACCCACTTCATCGAACTATGCTGCCAGCGCAAGATTGCGCTGCTGTTCCTGC
AGAACATCACCGGCTTCATGGTGGGCCGCAAGTACGAGAACGAGGGCATCGCGCGCAACGGCGCCAAGATGGTCACGGCC
GTGGCCACGGCCAGCGTGCCCAAGCTGACCCTGATCATCGGCGGCAGCTTTGGCGCGGGCAACTACGGCATGTGCGGCCG
GGCGTACAGCCCGCGCTTCCTGTGGATGTGGCCCAACGCACGCATCAGCGTGATGGGCGGCGAACAGGCTGCGGCGGTGC
TGGCCAGCGTCAAGCGCGACGGCATCGAGGCCCAGGGCGGCCAGTGGAGCATGCAGGAGGAAGAAGCCTTCAAAGCCCCG
ATCCGGCGCCAATATGAGCACCAGGGCCATCCCTACTACGCCACGGCGCGTCTGTGGGACGACGGCCTGATCGACCCCGC
CGACACACGCCGCGTGCTGGCACTGGGCCTGGCGGCCACGCGCAATGCTCCCATTGCAGACACGAAGTTCGGACTGCTGC
GCATGTAG

Upstream 100 bases:

>100_bases
ACCATCTTGGACATCCGGGAATGGGGCAGCGGCGGCAATGCGCACCACGACCCCGCTGGCATGACCGATAGACGCCTTGG
CTTGAAGAAAGCACCTGCGC

Downstream 100 bases:

>100_bases
GCGCCAGCGTGCGCCGCGATGGCACTGCAGCCCGCTGGAGCGGGCCGGCAGACATCGAGGCGCAGTGCCGCAGCGCCAGC
GTCCTGAAAAACCCGGCGCG

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTILDTRLNIRSADFLANAAAMRTLVDGLRAQLDKVAQGGGEAARAKHVARGKLLPRERVQMLLDPGTPFLELAPLAALD
MYDNDAPGAGLITGIGRVSGVDCMVVCNDATVKGGTYYPLTVKKHLRAQEVAQQNHLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFFNQAQMSAMGIAQIAVVMGSCTAGGAYVPAMSDESIIVQNQGTIFLGGPPLVKAATGEIVTAEDLGGGDVHTR
LSGVADHLALSDMHALQLARNALRNLNKNNAQAQVDHAPCAPKYAAQELYGVIPADPRKTFDVREIIARIVDGSEFDEFK
ARYGTTLVTGFARIEGMAVGIIANNGILFSESALKGTHFIELCCQRKIALLFLQNITGFMVGRKYENEGIARNGAKMVTA
VATASVPKLTLIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAAVLASVKRDGIEAQGGQWSMQEEEAFKAP
IRRQYEHQGHPYYATARLWDDGLIDPADTRRVLALGLAATRNAPIADTKFGLLRM

Sequences:

>Translated_535_residues
MTILDTRLNIRSADFLANAAAMRTLVDGLRAQLDKVAQGGGEAARAKHVARGKLLPRERVQMLLDPGTPFLELAPLAALD
MYDNDAPGAGLITGIGRVSGVDCMVVCNDATVKGGTYYPLTVKKHLRAQEVAQQNHLPCIYLVDSGGANLPNQDEVFPDR
DHFGRIFFNQAQMSAMGIAQIAVVMGSCTAGGAYVPAMSDESIIVQNQGTIFLGGPPLVKAATGEIVTAEDLGGGDVHTR
LSGVADHLALSDMHALQLARNALRNLNKNNAQAQVDHAPCAPKYAAQELYGVIPADPRKTFDVREIIARIVDGSEFDEFK
ARYGTTLVTGFARIEGMAVGIIANNGILFSESALKGTHFIELCCQRKIALLFLQNITGFMVGRKYENEGIARNGAKMVTA
VATASVPKLTLIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAAVLASVKRDGIEAQGGQWSMQEEEAFKAP
IRRQYEHQGHPYYATARLWDDGLIDPADTRRVLALGLAATRNAPIADTKFGLLRM
>Mature_534_residues
TILDTRLNIRSADFLANAAAMRTLVDGLRAQLDKVAQGGGEAARAKHVARGKLLPRERVQMLLDPGTPFLELAPLAALDM
YDNDAPGAGLITGIGRVSGVDCMVVCNDATVKGGTYYPLTVKKHLRAQEVAQQNHLPCIYLVDSGGANLPNQDEVFPDRD
HFGRIFFNQAQMSAMGIAQIAVVMGSCTAGGAYVPAMSDESIIVQNQGTIFLGGPPLVKAATGEIVTAEDLGGGDVHTRL
SGVADHLALSDMHALQLARNALRNLNKNNAQAQVDHAPCAPKYAAQELYGVIPADPRKTFDVREIIARIVDGSEFDEFKA
RYGTTLVTGFARIEGMAVGIIANNGILFSESALKGTHFIELCCQRKIALLFLQNITGFMVGRKYENEGIARNGAKMVTAV
ATASVPKLTLIIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAAVLASVKRDGIEAQGGQWSMQEEEAFKAPI
RRQYEHQGHPYYATARLWDDGLIDPADTRRVLALGLAATRNAPIADTKFGLLRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=66.0412757973734, Blast_Score=716, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=487, Percent_Identity=31.6221765913758, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI295821216, Length=507, Percent_Identity=30.1775147928994, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=58.7412587412587, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=60.2251407129456, Blast_Score=691, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=513, Percent_Identity=31.9688109161793, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25147359, Length=513, Percent_Identity=31.9688109161793, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=62.2504537205082, Blast_Score=704, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57501; Mature: 57370

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILDTRLNIRSADFLANAAAMRTLVDGLRAQLDKVAQGGGEAARAKHVARGKLLPRERV
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
QMLLDPGTPFLELAPLAALDMYDNDAPGAGLITGIGRVSGVDCMVVCNDATVKGGTYYPL
HEEECCCCCHHHHCCHHEEECCCCCCCCCCCEECCCCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEVAQQNHLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFFNQAQMSAMGIAQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHH
IAVVMGSCTAGGAYVPAMSDESIIVQNQGTIFLGGPPLVKAATGEIVTAEDLGGGDVHTR
HHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEECCCCCCHHHHH
LSGVADHLALSDMHALQLARNALRNLNKNNAQAQVDHAPCAPKYAAQELYGVIPADPRKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCC
FDVREIIARIVDGSEFDEFKARYGTTLVTGFARIEGMAVGIIANNGILFSESALKGTHFI
CCHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCHHHH
ELCCQRKIALLFLQNITGFMVGRKYENEGIARNGAKMVTAVATASVPKLTLIIGGSFGAG
HHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAAAVLASVKRDGIEAQGGQWSMQEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IRRQYEHQGHPYYATARLWDDGLIDPADTRRVLALGLAATRNAPIADTKFGLLRM
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TILDTRLNIRSADFLANAAAMRTLVDGLRAQLDKVAQGGGEAARAKHVARGKLLPRERV
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
QMLLDPGTPFLELAPLAALDMYDNDAPGAGLITGIGRVSGVDCMVVCNDATVKGGTYYPL
HEEECCCCCHHHHCCHHEEECCCCCCCCCCCEECCCCCCCCEEEEEECCCEECCCEEEEE
TVKKHLRAQEVAQQNHLPCIYLVDSGGANLPNQDEVFPDRDHFGRIFFNQAQMSAMGIAQ
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHH
IAVVMGSCTAGGAYVPAMSDESIIVQNQGTIFLGGPPLVKAATGEIVTAEDLGGGDVHTR
HHHHHHCCCCCCEEECCCCCCEEEEEECCEEEECCCCEEEECCCCEEEECCCCCCHHHHH
LSGVADHLALSDMHALQLARNALRNLNKNNAQAQVDHAPCAPKYAAQELYGVIPADPRKT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCC
FDVREIIARIVDGSEFDEFKARYGTTLVTGFARIEGMAVGIIANNGILFSESALKGTHFI
CCHHHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCCHHHH
ELCCQRKIALLFLQNITGFMVGRKYENEGIARNGAKMVTAVATASVPKLTLIIGGSFGAG
HHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCEEEEEHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAAAVLASVKRDGIEAQGGQWSMQEEEAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IRRQYEHQGHPYYATARLWDDGLIDPADTRRVLALGLAATRNAPIADTKFGLLRM
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEEEHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]