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The map label for this gene is gmk [H]

Identifier: 121611134

GI number: 121611134

Start: 4645865

End: 4646509

Strand: Direct

Name: gmk [H]

Synonym: Veis_4218

Alternate gene names: 121611134

Gene position: 4645865-4646509 (Clockwise)

Preceding gene: 121611131

Following gene: 121611135

Centisome position: 83.46

GC content: 60.93

Gene sequence:

>645_bases
ATGGCGCATGACACGCATCGACCCATGGACTATCCAGGAAACCTCATCGTAGTGGCAGCCCCCAGCGGCGCCGGAAAATC
CAGCCTGGTCAAGGCCCTGCAAGAGCTCGACGCGCACATTCACCCGTCGATTTCGCACACCACCCGCGCGCCCCGTGGCC
AGGAAAAGCATGGGCGCGAGTATTTCTTCGCGTCCGAATCCGAGTTCGACGCCATGGTCCAGGCCCAGGCTTTCGTCGAA
TGGGCGCATGTGCATGGCAAGCGCTATGGCACCTCGAAAAAAGCCATCGAAGAGCGCATCGCCCAAGGCTCGGATGTGAT
CCTGGAGATCGATTTTCAGGGCGCCTTGCAGATCAGGCAGGCGTTCGCCAACGCCGTGCTGGTATTCATCCTGCCGCCGG
GTTGGGACGAGTTGCGCTCGCGCCTGGAGCGCCGGGGCGAAGATTCGGCCGAGGTCATCGAAATGCGCCTGAAGAACGCG
GCCATCGAGATGGCCCATGTCAGTAAATTCGATTTCGTTATAATCAACGAATTGTTCGAACGCGCGCTTTTCGACCTGAA
AGCCGTGGTGCACGCCCAGCGCCTCAAGTACGCCGCCCAGCGCCGCGCCCGCGCTGACACCTTCGAGTCGCTCCACATCA
GTTGA

Upstream 100 bases:

>100_bases
GGGTTCAGAAGGTGTTGCATTGTGAAGATCCATAAAAATCAACGACTTGGAGCGCATCTCACGCTTCAGGTGCAAAACAT
CGAATGAAGCCCGTCTTTTG

Downstream 100 bases:

>100_bases
CGAATCACCCGAAATCCCCGAAAGGAAGACGATGGCCCGCATCACCGTAGAAGACTGTCTGGAAAAGATCCCCAACCGCT
TCCAACTCGTGTTGGCCGCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MAHDTHRPMDYPGNLIVVAAPSGAGKSSLVKALQELDAHIHPSISHTTRAPRGQEKHGREYFFASESEFDAMVQAQAFVE
WAHVHGKRYGTSKKAIEERIAQGSDVILEIDFQGALQIRQAFANAVLVFILPPGWDELRSRLERRGEDSAEVIEMRLKNA
AIEMAHVSKFDFVIINELFERALFDLKAVVHAQRLKYAAQRRARADTFESLHIS

Sequences:

>Translated_214_residues
MAHDTHRPMDYPGNLIVVAAPSGAGKSSLVKALQELDAHIHPSISHTTRAPRGQEKHGREYFFASESEFDAMVQAQAFVE
WAHVHGKRYGTSKKAIEERIAQGSDVILEIDFQGALQIRQAFANAVLVFILPPGWDELRSRLERRGEDSAEVIEMRLKNA
AIEMAHVSKFDFVIINELFERALFDLKAVVHAQRLKYAAQRRARADTFESLHIS
>Mature_213_residues
AHDTHRPMDYPGNLIVVAAPSGAGKSSLVKALQELDAHIHPSISHTTRAPRGQEKHGREYFFASESEFDAMVQAQAFVEW
AHVHGKRYGTSKKAIEERIAQGSDVILEIDFQGALQIRQAFANAVLVFILPPGWDELRSRLERRGEDSAEVIEMRLKNAA
IEMAHVSKFDFVIINELFERALFDLKAVVHAQRLKYAAQRRARADTFESLHIS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=35.2272727272727, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI226874833, Length=176, Percent_Identity=35.2272727272727, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4504221, Length=176, Percent_Identity=35.2272727272727, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI38570142, Length=179, Percent_Identity=27.9329608938547, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=25.9067357512953, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=26.8421052631579, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI52630447, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI262118255, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI4505237, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI262118263, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI262118259, Length=176, Percent_Identity=26.7045454545455, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI111154074, Length=164, Percent_Identity=28.6585365853659, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790080, Length=194, Percent_Identity=50, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=185, Percent_Identity=36.7567567567568, Blast_Score=123, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=36.9318181818182, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=37.1584699453552, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21356141, Length=164, Percent_Identity=40.8536585365854, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=30.3867403314917, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330162, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330166, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330164, Length=137, Percent_Identity=29.9270072992701, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24115; Mature: 23983

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDTHRPMDYPGNLIVVAAPSGAGKSSLVKALQELDAHIHPSISHTTRAPRGQEKHGRE
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCE
YFFASESEFDAMVQAQAFVEWAHVHGKRYGTSKKAIEERIAQGSDVILEIDFQGALQIRQ
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHH
AFANAVLVFILPPGWDELRSRLERRGEDSAEVIEMRLKNAAIEMAHVSKFDFVIINELFE
HHHCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RALFDLKAVVHAQRLKYAAQRRARADTFESLHIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AHDTHRPMDYPGNLIVVAAPSGAGKSSLVKALQELDAHIHPSISHTTRAPRGQEKHGRE
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCE
YFFASESEFDAMVQAQAFVEWAHVHGKRYGTSKKAIEERIAQGSDVILEIDFQGALQIRQ
EEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHH
AFANAVLVFILPPGWDELRSRLERRGEDSAEVIEMRLKNAAIEMAHVSKFDFVIINELFE
HHHCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
RALFDLKAVVHAQRLKYAAQRRARADTFESLHIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA