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The map label for this gene is yngE [H]

Identifier: 121611099

GI number: 121611099

Start: 4605112

End: 4606773

Strand: Direct

Name: yngE [H]

Synonym: Veis_4183

Alternate gene names: 121611099

Gene position: 4605112-4606773 (Clockwise)

Preceding gene: 121611098

Following gene: 121611100

Centisome position: 82.73

GC content: 68.53

Gene sequence:

>1662_bases
ATGTGGCGCCTCGCAGGCGGCACGATCGACGAGGAGCAGATGACGACACTTGCATCGAACCTGGCACCGGCCAGCCCCGC
GTACACGCGCAACAAAGCCCACATGCTGGATCTGGTGGAACAGGTGCGCGCGCTCGAGCAGCGCGCGGTCCTGCGCTCGG
CGCGCTCGGCCGCCAACTTTCACGCGCGCGGCAAGCTGCTGCCGCGTGAACGGCTCGCCCACCTGCTGGACTCGGGCCGC
CCCTTTCTCGAACTGATGACGCTGGCGGGCTACTGCGGCATCGAGGACCGCGACCCAGCCACCAGCATCCCGGGCAGCGC
GCTGATCGTGGGCATCGGCCACATCTCGGGCGTGCGCTGCATGGTCGCCGTGAACGACGCGGGCATCAGCGCCGGCGCGA
TGCAGTCACTCACCGGCCAGAAGTTGATCCGTGCGCAAGAGATCGCGCTCGCGCACAAGCTGCCTTTCGTGCAGCTGGTG
GAAAGCGCGGGCGGCAACCTCAAGAAGTACCGCGTCGAGCGCTTCATCGTCGGCGGCGGCATGTTCTACAACCTCGCGCG
GTTGTCGGCGGCGGGACTGCCGGTGATTTCGCTCATCCACGGCTCGTCGGCCGCCGGCGGCGCCTATCTGCCAGGGCTGT
CCGATTACGTGGTCATGGTGCGCCAGCAGGCGCGCGCTTTTCTCGCGGGTCCCGCGCTGCTCAAGGCGGCCACGGGCGAA
GAAGCCACCGAGGAAGAACTCGGCGGTGCCGACATGCACGCGCGCACCTCGGGCCTGGCCGACTACGTGGCCGAGAACGA
CCTGGACGGCATCGCGCGCATCCGCGACATCCTGCGCGCGATCGGCTGGACCGACACCGCGGTATTGCCGGCTTCGCCCA
TCCGTCCACCGCGCCATGACCGCGAAGACCTGCTGGGCGTGATGCCCGCTGACGCTCGCACGCCGGTGGACATGCGCGAA
GTCATCGCACGCCTGGTCGACGACTCGGACTTCCACGAGTTCAAGCAGCTGTATGGTGCACCCACCGTGTGCGGCTACGC
CACCGTGCACGGCCAGCCGGTCGGCATCCTCACCAACAACGGGCCGCTCGATCCGGCGGGGGCCACCAAGGCCGCCGAGT
TCATCCAGCTGTGCGTGCAGCTGGACCGCCCGATCCTGTTCCTGCAGAACATCACCGGCTTCATCGTCGGCCGCGCGCAC
GAAGAGGCCGGGATGATCAAGCACGGCGCCAAGCTGATCCAGGCGCTGTCGAACGCGCCCGTGCCGCGCATCACGCTGCT
GTGCGGCGCCTCGTTCGGTGCCGGCAACTACGGCATGTGCGGCCGCGCGTTCAAGCCCGACTTTTTGTTCTCGTGGCCCA
ACGCCAAGACCGCCGTGATGGGCGGCGAGCAGGCTGCGATGACGATGCGCATGGTGGCCGAGGGCGCCGCACGGCGCGCG
GGACGCGCGGTCGACGAAGACGCACTGGCCCAGGAGAGCCGCGAGATCGTCGACAACTTCAACGAGCAGTCGACCGCCAT
CTACACCAGCAGCCTGCTGCTGGACGACGGAATCATCGACCCGCGCAACACGCGCGAAGTGCTCGGCGTGGTGCTCAAGA
CCGCCGCCGCCGCGAAGACGCGCCCCGTCATCCCGATCCAGTTCGGCGTCGCGCGCTTCTGA

Upstream 100 bases:

>100_bases
ATCAGTTCGGTCTGAAAATCTTGATGGAAATCGGTGCACCCCACTGCCATCATCCCCGACAGACAGGGCATGCACGGCAC
CGCACCGTGGTCAACCACCC

Downstream 100 bases:

>100_bases
CGCGCGCCCTGTTCCCCACACGACAACAAGAGACAAGACAGAAATGACCATCGATCGACGTGTGATGCTGGCCACCATGG
CCACCATGGCCGGCTTGGCC

Product: propionyl-CoA carboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MWRLAGGTIDEEQMTTLASNLAPASPAYTRNKAHMLDLVEQVRALEQRAVLRSARSAANFHARGKLLPRERLAHLLDSGR
PFLELMTLAGYCGIEDRDPATSIPGSALIVGIGHISGVRCMVAVNDAGISAGAMQSLTGQKLIRAQEIALAHKLPFVQLV
ESAGGNLKKYRVERFIVGGGMFYNLARLSAAGLPVISLIHGSSAAGGAYLPGLSDYVVMVRQQARAFLAGPALLKAATGE
EATEEELGGADMHARTSGLADYVAENDLDGIARIRDILRAIGWTDTAVLPASPIRPPRHDREDLLGVMPADARTPVDMRE
VIARLVDDSDFHEFKQLYGAPTVCGYATVHGQPVGILTNNGPLDPAGATKAAEFIQLCVQLDRPILFLQNITGFIVGRAH
EEAGMIKHGAKLIQALSNAPVPRITLLCGASFGAGNYGMCGRAFKPDFLFSWPNAKTAVMGGEQAAMTMRMVAEGAARRA
GRAVDEDALAQESREIVDNFNEQSTAIYTSSLLLDDGIIDPRNTREVLGVVLKTAAAAKTRPVIPIQFGVARF

Sequences:

>Translated_553_residues
MWRLAGGTIDEEQMTTLASNLAPASPAYTRNKAHMLDLVEQVRALEQRAVLRSARSAANFHARGKLLPRERLAHLLDSGR
PFLELMTLAGYCGIEDRDPATSIPGSALIVGIGHISGVRCMVAVNDAGISAGAMQSLTGQKLIRAQEIALAHKLPFVQLV
ESAGGNLKKYRVERFIVGGGMFYNLARLSAAGLPVISLIHGSSAAGGAYLPGLSDYVVMVRQQARAFLAGPALLKAATGE
EATEEELGGADMHARTSGLADYVAENDLDGIARIRDILRAIGWTDTAVLPASPIRPPRHDREDLLGVMPADARTPVDMRE
VIARLVDDSDFHEFKQLYGAPTVCGYATVHGQPVGILTNNGPLDPAGATKAAEFIQLCVQLDRPILFLQNITGFIVGRAH
EEAGMIKHGAKLIQALSNAPVPRITLLCGASFGAGNYGMCGRAFKPDFLFSWPNAKTAVMGGEQAAMTMRMVAEGAARRA
GRAVDEDALAQESREIVDNFNEQSTAIYTSSLLLDDGIIDPRNTREVLGVVLKTAAAAKTRPVIPIQFGVARF
>Mature_553_residues
MWRLAGGTIDEEQMTTLASNLAPASPAYTRNKAHMLDLVEQVRALEQRAVLRSARSAANFHARGKLLPRERLAHLLDSGR
PFLELMTLAGYCGIEDRDPATSIPGSALIVGIGHISGVRCMVAVNDAGISAGAMQSLTGQKLIRAQEIALAHKLPFVQLV
ESAGGNLKKYRVERFIVGGGMFYNLARLSAAGLPVISLIHGSSAAGGAYLPGLSDYVVMVRQQARAFLAGPALLKAATGE
EATEEELGGADMHARTSGLADYVAENDLDGIARIRDILRAIGWTDTAVLPASPIRPPRHDREDLLGVMPADARTPVDMRE
VIARLVDDSDFHEFKQLYGAPTVCGYATVHGQPVGILTNNGPLDPAGATKAAEFIQLCVQLDRPILFLQNITGFIVGRAH
EEAGMIKHGAKLIQALSNAPVPRITLLCGASFGAGNYGMCGRAFKPDFLFSWPNAKTAVMGGEQAAMTMRMVAEGAARRA
GRAVDEDALAQESREIVDNFNEQSTAIYTSSLLLDDGIIDPRNTREVLGVVLKTAAAAKTRPVIPIQFGVARF

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=550, Percent_Identity=42.3636363636364, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI119943100, Length=417, Percent_Identity=31.1750599520384, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI295821216, Length=437, Percent_Identity=29.5194508009153, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI310133460, Length=139, Percent_Identity=41.726618705036, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552936, Length=544, Percent_Identity=40.0735294117647, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI25147362, Length=512, Percent_Identity=30.859375, Blast_Score=235, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI25147359, Length=514, Percent_Identity=30.9338521400778, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24586065, Length=558, Percent_Identity=41.7562724014337, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: NA

Molecular weight: Translated: 59076; Mature: 59076

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRLAGGTIDEEQMTTLASNLAPASPAYTRNKAHMLDLVEQVRALEQRAVLRSARSAANF
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
HARGKLLPRERLAHLLDSGRPFLELMTLAGYCGIEDRDPATSIPGSALIVGIGHISGVRC
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
MVAVNDAGISAGAMQSLTGQKLIRAQEIALAHKLPFVQLVESAGGNLKKYRVERFIVGGG
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHEEEEEEEECCH
MFYNLARLSAAGLPVISLIHGSSAAGGAYLPGLSDYVVMVRQQARAFLAGPALLKAATGE
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCC
EATEEELGGADMHARTSGLADYVAENDLDGIARIRDILRAIGWTDTAVLPASPIRPPRHD
CHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
REDLLGVMPADARTPVDMREVIARLVDDSDFHEFKQLYGAPTVCGYATVHGQPVGILTNN
HHHHHEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEECC
GPLDPAGATKAAEFIQLCVQLDRPILFLQNITGFIVGRAHEEAGMIKHGAKLIQALSNAP
CCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHEEECCHHHHHHHHHHHHHHHHHHCCC
VPRITLLCGASFGAGNYGMCGRAFKPDFLFSWPNAKTAVMGGEQAAMTMRMVAEGAARRA
CCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHH
GRAVDEDALAQESREIVDNFNEQSTAIYTSSLLLDDGIIDPRNTREVLGVVLKTAAAAKT
CCCCCHHHHHHHHHHHHHCCCCCHHEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
RPVIPIQFGVARF
CCCEEECCCCCCC
>Mature Secondary Structure
MWRLAGGTIDEEQMTTLASNLAPASPAYTRNKAHMLDLVEQVRALEQRAVLRSARSAANF
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
HARGKLLPRERLAHLLDSGRPFLELMTLAGYCGIEDRDPATSIPGSALIVGIGHISGVRC
HHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEE
MVAVNDAGISAGAMQSLTGQKLIRAQEIALAHKLPFVQLVESAGGNLKKYRVERFIVGGG
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHEEEEEEEECCH
MFYNLARLSAAGLPVISLIHGSSAAGGAYLPGLSDYVVMVRQQARAFLAGPALLKAATGE
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCC
EATEEELGGADMHARTSGLADYVAENDLDGIARIRDILRAIGWTDTAVLPASPIRPPRHD
CHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
REDLLGVMPADARTPVDMREVIARLVDDSDFHEFKQLYGAPTVCGYATVHGQPVGILTNN
HHHHHEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCEEEEEECC
GPLDPAGATKAAEFIQLCVQLDRPILFLQNITGFIVGRAHEEAGMIKHGAKLIQALSNAP
CCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCHHEEECCHHHHHHHHHHHHHHHHHHCCC
VPRITLLCGASFGAGNYGMCGRAFKPDFLFSWPNAKTAVMGGEQAAMTMRMVAEGAARRA
CCEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCHHHHHHHHHHHHHHHHHH
GRAVDEDALAQESREIVDNFNEQSTAIYTSSLLLDDGIIDPRNTREVLGVVLKTAAAAKT
CCCCCHHHHHHHHHHHHHCCCCCHHEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
RPVIPIQFGVARF
CCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]