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The map label for this gene is rutR [H]

Identifier: 121611069

GI number: 121611069

Start: 4570850

End: 4571554

Strand: Direct

Name: rutR [H]

Synonym: Veis_4153

Alternate gene names: 121611069

Gene position: 4570850-4571554 (Clockwise)

Preceding gene: 121611063

Following gene: 121611070

Centisome position: 82.11

GC content: 67.09

Gene sequence:

>705_bases
ATGACCGACATCCGCCAGTTCACCAACGACAGCGCCGCACGCGCCACCACCGACAAAGACCCCGCCCCCCGTGCACCCCG
GGCCTCGCGCCTGCTCAAGGAGCAGGGCATCCTGGCGCAGGCCGAGAACCACTTTGCCCAGTTCGGCTTCGAGGGCGCAT
CGCTGGAGAGCATTGCTGCGGCCATCGGCATCAGCCGCCATAAGCTGCTGTACTACTTTCCCAGCAAGGAGGCGCTCTAC
CAGCGCGTGCTCGACGATGTGCTGACCCAGTGGCTGGCCAGCATGCAAGACATCTCGCACAGCGACGACCCGCAGCAGGC
CCTGCGCCGCTACATCCACGCCAAGCTGCATTACTCGCGCACCCGCCCCCAGGGCGTGCAGGTGTTCGCCAAAGAGGTGA
TTGCCGGCGCGCCGCGCTATGGCCGGGTGATCGCCGAGCGCGTCGCACCGCTGCTCAAGACCGATGTGCGCCGCTTCGCG
CGCTGGGCGCGCGAAGGGCGCATCGCCAAGGTGGACTTCACGCACCTGATGTTCATCATCTGGTCGGTCACGCAAGCCTA
CGCGGAACTGCAAGCGCAGTTCGCGCTGCTGCTGGGCAAGCCGGCCCTGACCGAGGGCGACTATGAAAAGGCCGAGGCGC
TGATCGTGCGCATGGTGCTCAGCGCACTGGCGCCAGATGCTGCCGGCCCGGGCCAAGCGCCATGA

Upstream 100 bases:

>100_bases
ACCAAGCCGTAAAAATTTACCAATTGGTAAAATCCCTGAAGCAAGCCCCATGCCTGTCCACCCCGGGGGGACGGCGCCCG
GCTTGTCCCACAATGGTGCG

Downstream 100 bases:

>100_bases
CGCCATGACGCCATGCGCCGCCTGTCGCCTGTCGCCTGCGGCGTGCGCGCAGACGCGCGGGCTGCGGCATCTGCGGCCCT
TGCTGCGTCGCCTGCGGCGT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Rut operon repressor [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTDIRQFTNDSAARATTDKDPAPRAPRASRLLKEQGILAQAENHFAQFGFEGASLESIAAAIGISRHKLLYYFPSKEALY
QRVLDDVLTQWLASMQDISHSDDPQQALRRYIHAKLHYSRTRPQGVQVFAKEVIAGAPRYGRVIAERVAPLLKTDVRRFA
RWAREGRIAKVDFTHLMFIIWSVTQAYAELQAQFALLLGKPALTEGDYEKAEALIVRMVLSALAPDAAGPGQAP

Sequences:

>Translated_234_residues
MTDIRQFTNDSAARATTDKDPAPRAPRASRLLKEQGILAQAENHFAQFGFEGASLESIAAAIGISRHKLLYYFPSKEALY
QRVLDDVLTQWLASMQDISHSDDPQQALRRYIHAKLHYSRTRPQGVQVFAKEVIAGAPRYGRVIAERVAPLLKTDVRRFA
RWAREGRIAKVDFTHLMFIIWSVTQAYAELQAQFALLLGKPALTEGDYEKAEALIVRMVLSALAPDAAGPGQAP
>Mature_233_residues
TDIRQFTNDSAARATTDKDPAPRAPRASRLLKEQGILAQAENHFAQFGFEGASLESIAAAIGISRHKLLYYFPSKEALYQ
RVLDDVLTQWLASMQDISHSDDPQQALRRYIHAKLHYSRTRPQGVQVFAKEVIAGAPRYGRVIAERVAPLLKTDVRRFAR
WAREGRIAKVDFTHLMFIIWSVTQAYAELQAQFALLLGKPALTEGDYEKAEALIVRMVLSALAPDAAGPGQAP

Specific function: Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance between pyrimidines and purines. It also regulates the synthesis of pyrimidine nucleotides and arginin

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787249, Length=193, Percent_Identity=36.2694300518135, Blast_Score=131, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR019915
- InterPro:   IPR001647
- InterPro:   IPR013573 [H]

Pfam domain/function: PF08362 TetR_C_3; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 26102; Mature: 25971

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIRQFTNDSAARATTDKDPAPRAPRASRLLKEQGILAQAENHFAQFGFEGASLESIAA
CCCHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHH
AIGISRHKLLYYFPSKEALYQRVLDDVLTQWLASMQDISHSDDPQQALRRYIHAKLHYSR
HHCCHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
TRPQGVQVFAKEVIAGAPRYGRVIAERVAPLLKTDVRRFARWAREGRIAKVDFTHLMFII
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
WSVTQAYAELQAQFALLLGKPALTEGDYEKAEALIVRMVLSALAPDAAGPGQAP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDIRQFTNDSAARATTDKDPAPRAPRASRLLKEQGILAQAENHFAQFGFEGASLESIAA
CCHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHH
AIGISRHKLLYYFPSKEALYQRVLDDVLTQWLASMQDISHSDDPQQALRRYIHAKLHYSR
HHCCHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
TRPQGVQVFAKEVIAGAPRYGRVIAERVAPLLKTDVRRFARWAREGRIAKVDFTHLMFII
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
WSVTQAYAELQAQFALLLGKPALTEGDYEKAEALIVRMVLSALAPDAAGPGQAP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]