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The map label for this gene is livH [H]

Identifier: 121610870

GI number: 121610870

Start: 4336544

End: 4337626

Strand: Direct

Name: livH [H]

Synonym: Veis_3952

Alternate gene names: 121610870

Gene position: 4336544-4337626 (Clockwise)

Preceding gene: 121610869

Following gene: 121610871

Centisome position: 77.9

GC content: 69.44

Gene sequence:

>1083_bases
ATGGATTTGCAGATTGCCCTGCTGTTGGTGCAAGACGGCCTGGTCAATGGCGCCATCTACGGACTGATGGCGCTGGCCCT
GGTGCTGGTTTTTTCCGTGACCCGGGTGATCTTCATCCCCCAGGGCGAGTTCGTGGCCTTTGGCGCGCTGACCATGGTCA
TGCTGCAAGGGGGGCGCATTCCGCCCACGCTGTGGCTGCTGCTGGCGCTGGCCGCCGTGGTGCTGGCGGGGGAACTGCTG
CGCCGCATCGGCGGCCACGCCGTCCACTGGCCGAGCACCCTGCTGTGGTGCGTGGCGTTGCCGCTGCTGGCTTGCGCGCT
GGTGTGGCTGCCGGGCCTGCGCCCGGCGCTGGAGTCGGGCCTGCGCCCGGCAGCGTTGGAACCGGGCCTGCACCCGGTGT
CGTTGTACCTGCACGCGCTGACCACGCTGGTGCTGATCGCCCCGCTGGGCCCGCTGCTGTACCGCCTGGCTTTTCGGCCG
CTGGCCGATGCCTCGGTGCTGATGCTGCTCATCGTCGCGGTGGCGCTGCATGGCGTGCTGGTGGGGCTGGGCCTGCTGTT
CTTCGGCGCCGAGGGTGCGCGCACGCCAGCGTTTGTCGAGGCCCGCTGGGAGTTCGGCGGCATGGCCGTTTCGGGCCAGT
CGCTGGTGGTGCTGGGCGTCACGCTGGCGCTGCTGGGGCTGCTGCTGATCCTGGGCCGCTCCATGGTCGGCAAGGCGCTG
CGCGCCACGGCCATCAACCGGGTGGGCGCGCGGCTGATGGGCATTCCCACCGAGCGCTCGGCAGAGCTGAGCTTTGCGCT
GGCGGCGCTGATCGGCGCGGTCTCGGGCCTGCTGATCGCGCCGCTGACCACCGTGTACTACGACACCGGTTTCCTGATCG
GTCTGAAAGGCTTTGTGGCGGCCATCGTGGGCGCATTGGCCAGCTACCCGCTGGCGCTGGCCGGCGCCCTGCTGGTGGGC
CAACTGGAGGCCTTTGCCTCGTTCTGGGCCAGCGCCTACAAGGAGGTTCTGGTGTTCACGCTGATCGTTCCGGTGCTGTG
GTGGCGCTCGCTCGGCAGCCGCCTGGTGGAGGATGAGGAGTGA

Upstream 100 bases:

>100_bases
GCATGTCCGAGACCGACCACCTGGGCCTGGACCAGCGTGCCCGGGTGATGGTCAAGATCGAAAACGGCGCCTGGAAATAC
CAGCCCTGAGCCATCCGGCC

Downstream 100 bases:

>100_bases
CGCCCCCGGCCGAGACAGACCTGCGCTGCGCTGCGCGCAGCCGGTTCATGCACCGGCTCACGCGCGCGCGGCTCACGCTG
GCGGCCTTGGCCCTGCTGGT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MDLQIALLLVQDGLVNGAIYGLMALALVLVFSVTRVIFIPQGEFVAFGALTMVMLQGGRIPPTLWLLLALAAVVLAGELL
RRIGGHAVHWPSTLLWCVALPLLACALVWLPGLRPALESGLRPAALEPGLHPVSLYLHALTTLVLIAPLGPLLYRLAFRP
LADASVLMLLIVAVALHGVLVGLGLLFFGAEGARTPAFVEARWEFGGMAVSGQSLVVLGVTLALLGLLLILGRSMVGKAL
RATAINRVGARLMGIPTERSAELSFALAALIGAVSGLLIAPLTTVYYDTGFLIGLKGFVAAIVGALASYPLALAGALLVG
QLEAFASFWASAYKEVLVFTLIVPVLWWRSLGSRLVEDEE

Sequences:

>Translated_360_residues
MDLQIALLLVQDGLVNGAIYGLMALALVLVFSVTRVIFIPQGEFVAFGALTMVMLQGGRIPPTLWLLLALAAVVLAGELL
RRIGGHAVHWPSTLLWCVALPLLACALVWLPGLRPALESGLRPAALEPGLHPVSLYLHALTTLVLIAPLGPLLYRLAFRP
LADASVLMLLIVAVALHGVLVGLGLLFFGAEGARTPAFVEARWEFGGMAVSGQSLVVLGVTLALLGLLLILGRSMVGKAL
RATAINRVGARLMGIPTERSAELSFALAALIGAVSGLLIAPLTTVYYDTGFLIGLKGFVAAIVGALASYPLALAGALLVG
QLEAFASFWASAYKEVLVFTLIVPVLWWRSLGSRLVEDEE
>Mature_360_residues
MDLQIALLLVQDGLVNGAIYGLMALALVLVFSVTRVIFIPQGEFVAFGALTMVMLQGGRIPPTLWLLLALAAVVLAGELL
RRIGGHAVHWPSTLLWCVALPLLACALVWLPGLRPALESGLRPAALEPGLHPVSLYLHALTTLVLIAPLGPLLYRLAFRP
LADASVLMLLIVAVALHGVLVGLGLLFFGAEGARTPAFVEARWEFGGMAVSGQSLVVLGVTLALLGLLLILGRSMVGKAL
RATAINRVGARLMGIPTERSAELSFALAALIGAVSGLLIAPLTTVYYDTGFLIGLKGFVAAIVGALASYPLALAGALLVG
QLEAFASFWASAYKEVLVFTLIVPVLWWRSLGSRLVEDEE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=212, Percent_Identity=30.6603773584906, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 37930; Mature: 37930

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLQIALLLVQDGLVNGAIYGLMALALVLVFSVTRVIFIPQGEFVAFGALTMVMLQGGRI
CCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCC
PPTLWLLLALAAVVLAGELLRRIGGHAVHWPSTLLWCVALPLLACALVWLPGLRPALESG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
LRPAALEPGLHPVSLYLHALTTLVLIAPLGPLLYRLAFRPLADASVLMLLIVAVALHGVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VGLGLLFFGAEGARTPAFVEARWEFGGMAVSGQSLVVLGVTLALLGLLLILGRSMVGKAL
HHHHHHHHCCCCCCCCHHEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATAINRVGARLMGIPTERSAELSFALAALIGAVSGLLIAPLTTVYYDTGFLIGLKGFVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
AIVGALASYPLALAGALLVGQLEAFASFWASAYKEVLVFTLIVPVLWWRSLGSRLVEDEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLQIALLLVQDGLVNGAIYGLMALALVLVFSVTRVIFIPQGEFVAFGALTMVMLQGGRI
CCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCCCC
PPTLWLLLALAAVVLAGELLRRIGGHAVHWPSTLLWCVALPLLACALVWLPGLRPALESG
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCC
LRPAALEPGLHPVSLYLHALTTLVLIAPLGPLLYRLAFRPLADASVLMLLIVAVALHGVL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VGLGLLFFGAEGARTPAFVEARWEFGGMAVSGQSLVVLGVTLALLGLLLILGRSMVGKAL
HHHHHHHHCCCCCCCCHHEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RATAINRVGARLMGIPTERSAELSFALAALIGAVSGLLIAPLTTVYYDTGFLIGLKGFVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
AIVGALASYPLALAGALLVGQLEAFASFWASAYKEVLVFTLIVPVLWWRSLGSRLVEDEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]