Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 121610377

GI number: 121610377

Start: 3817848

End: 3819593

Strand: Direct

Name: ggt [H]

Synonym: Veis_3445

Alternate gene names: 121610377

Gene position: 3817848-3819593 (Clockwise)

Preceding gene: 121610369

Following gene: 121610384

Centisome position: 68.58

GC content: 59.68

Gene sequence:

>1746_bases
ATGTGGAAAATCAAAGGCTTCATCAAATCAACCTGTATTGCATTACTGCCCCTCTACACTTTCTGCGCATTTGCCCAGGC
ACAAACTGCGGCGCAGGCCCCCCGGTATGACCTGACCTACGACATCATCAGCCCGGTGATGGGCAGAAATGGCATGGTCG
CTTCCGAGCAGGCGCTGGCCTCGCAAGTCGGTCTCGACATCCTCCAGCGTGGCGGCAATGCCGTCGATGCTGCCGTTGCG
GTCGGCTTTGCCTTGGCGGTCGTGCTGCCGAATGCCGGCAATATCGGCGGTGGCGGTTTCATGATGATTCACGATGCAAA
GACCGGCAAAAACGTCGCCCTCGATTTCCGTGAAATGGCGCCGGCCAAAGCCAGCCGCGACATGTATCTGGATGGGCAGG
GCAATGTCGTGCCCGGACGCTCGCTCCATACCCACCTCGCCGTCGGCGTGCCCGGCACGGTCGCGGGCCTGGCCCACGCG
CTGCAAAAATACGGCACGATGAAACTCTCCGACGTGATTGCGCCGGCGGTCGAGCTGGCTGAAACAGGCTACCCTGTCAG
CCCGGGTCTGGCGCTGATTCTGGCCGAAGAACGCGCGCACCTCGGTCAATGGGAATCGAGCAAGGCGATTTTCTTCAAGG
ACGGCCGTCCGCTGCAAGCCGGTGAACGGCTGGTGCAAAAAGACCTGGCCAGGTCGCTCGAACTGATCGGCAAGCAAGGC
CCGGCTGCCTTCTATGAAGGCGAGATCGGCCAGAAAATCGTCGCTGAAATGGCGCAGCACCAGGGCTTGATCACCAGCGC
CGATCTGAAGAATTACAAGGTGATCGAACGCGAGCCGGTGGTTGGCAATTATCGTGGCTATCAGGTGGTGTCGATGCCGC
CGCCAAGCTCAGGCGGTGTTCACATCATCCAGATGATGAATATCCTCGAACGCTATCCCTTGCAGCAATACGGCGCCAAC
AGCGCACAAACCATCCATCTGAAGGCCGAAGCGATGAAACGGGCTTATGCCGATCGCGCCGAATATCTGGGCGATCCGGA
TTTCACCAAGGTGCCGGTCAAGGGGCTGACATCGCGCGCCTATGCCGATGAGTTGGCGCAGAAAATCGATCCAGAGCGCG
CCACTCCCTCCTCAGACATCAAGCCCGGCAAACCGCTGCCTCATGAAAGCGATCAAACCACGCACTTTTCCGTTGCCGAC
GAGAAAGGCAATCTGGTCGCCGCCACTTATACGCTGAATCTGAATTTCGGCAGCGGCATCGTCGCCGCCGGCACCGGCAT
CATGCTCAACAATGAGATGGATGACTTCTCGGCCAAGCCCGGCGTGCCAAACGCCTTCGGCCTGGTGGGTGGTGACGCCA
ACGCCGTCGGCCCCGGCAAACGCCCGCTGAGCTCCATGTCGCCGACCTTTGTGCTCAAGGATGGCAAGCCATTCCTGGCC
ACTGGCAGCCCGGGCGGCAGCCGCATCATCACCACCACGATGCAAACCATCCTGAACGTGATCGACCACGACATGAACGT
TGCCGAAGCAGCGGTCACGCCGCGCATCCACCACCAATGGGCGCCAGATCAGTTGCGTATCGAAAAAGGCATCAGCGCCG
ATACGCTCAGGATTTTGCAAAACAAGGGGCAAACCATCAGCGTGCAGCCTGCCATGGGGCGCACCCAAACCATACAGATC
AAGGATGGCGCTTTCTACGGCTATTCAGACCCGCGCAATCCGGATGGACGCACGCTGGGATTTTGA

Upstream 100 bases:

>100_bases
ACGGCGGTGTGCCTTCCTCCAAAAATTCATCCATCATTTTATGGGCAGTGCGTTTTCCAAGGCTACAATCCCGAGAATGT
CACTGTCCAGGAGATCTCCC

Downstream 100 bases:

>100_bases
GGCCGTTCAATCGGGTTCATACAGCGCGGCTTCGACCCTGCCTGCGCGCAGGCCGACTTGGCCAAGCCCGGGGAAGCGAA
CCAGCACCTCGGCGTTTGCC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MWKIKGFIKSTCIALLPLYTFCAFAQAQTAAQAPRYDLTYDIISPVMGRNGMVASEQALASQVGLDILQRGGNAVDAAVA
VGFALAVVLPNAGNIGGGGFMMIHDAKTGKNVALDFREMAPAKASRDMYLDGQGNVVPGRSLHTHLAVGVPGTVAGLAHA
LQKYGTMKLSDVIAPAVELAETGYPVSPGLALILAEERAHLGQWESSKAIFFKDGRPLQAGERLVQKDLARSLELIGKQG
PAAFYEGEIGQKIVAEMAQHQGLITSADLKNYKVIEREPVVGNYRGYQVVSMPPPSSGGVHIIQMMNILERYPLQQYGAN
SAQTIHLKAEAMKRAYADRAEYLGDPDFTKVPVKGLTSRAYADELAQKIDPERATPSSDIKPGKPLPHESDQTTHFSVAD
EKGNLVAATYTLNLNFGSGIVAAGTGIMLNNEMDDFSAKPGVPNAFGLVGGDANAVGPGKRPLSSMSPTFVLKDGKPFLA
TGSPGGSRIITTTMQTILNVIDHDMNVAEAAVTPRIHHQWAPDQLRIEKGISADTLRILQNKGQTISVQPAMGRTQTIQI
KDGAFYGYSDPRNPDGRTLGF

Sequences:

>Translated_581_residues
MWKIKGFIKSTCIALLPLYTFCAFAQAQTAAQAPRYDLTYDIISPVMGRNGMVASEQALASQVGLDILQRGGNAVDAAVA
VGFALAVVLPNAGNIGGGGFMMIHDAKTGKNVALDFREMAPAKASRDMYLDGQGNVVPGRSLHTHLAVGVPGTVAGLAHA
LQKYGTMKLSDVIAPAVELAETGYPVSPGLALILAEERAHLGQWESSKAIFFKDGRPLQAGERLVQKDLARSLELIGKQG
PAAFYEGEIGQKIVAEMAQHQGLITSADLKNYKVIEREPVVGNYRGYQVVSMPPPSSGGVHIIQMMNILERYPLQQYGAN
SAQTIHLKAEAMKRAYADRAEYLGDPDFTKVPVKGLTSRAYADELAQKIDPERATPSSDIKPGKPLPHESDQTTHFSVAD
EKGNLVAATYTLNLNFGSGIVAAGTGIMLNNEMDDFSAKPGVPNAFGLVGGDANAVGPGKRPLSSMSPTFVLKDGKPFLA
TGSPGGSRIITTTMQTILNVIDHDMNVAEAAVTPRIHHQWAPDQLRIEKGISADTLRILQNKGQTISVQPAMGRTQTIQI
KDGAFYGYSDPRNPDGRTLGF
>Mature_581_residues
MWKIKGFIKSTCIALLPLYTFCAFAQAQTAAQAPRYDLTYDIISPVMGRNGMVASEQALASQVGLDILQRGGNAVDAAVA
VGFALAVVLPNAGNIGGGGFMMIHDAKTGKNVALDFREMAPAKASRDMYLDGQGNVVPGRSLHTHLAVGVPGTVAGLAHA
LQKYGTMKLSDVIAPAVELAETGYPVSPGLALILAEERAHLGQWESSKAIFFKDGRPLQAGERLVQKDLARSLELIGKQG
PAAFYEGEIGQKIVAEMAQHQGLITSADLKNYKVIEREPVVGNYRGYQVVSMPPPSSGGVHIIQMMNILERYPLQQYGAN
SAQTIHLKAEAMKRAYADRAEYLGDPDFTKVPVKGLTSRAYADELAQKIDPERATPSSDIKPGKPLPHESDQTTHFSVAD
EKGNLVAATYTLNLNFGSGIVAAGTGIMLNNEMDDFSAKPGVPNAFGLVGGDANAVGPGKRPLSSMSPTFVLKDGKPFLA
TGSPGGSRIITTTMQTILNVIDHDMNVAEAAVTPRIHHQWAPDQLRIEKGISADTLRILQNKGQTISVQPAMGRTQTIQI
KDGAFYGYSDPRNPDGRTLGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=528, Percent_Identity=33.1439393939394, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI73915090, Length=528, Percent_Identity=33.1439393939394, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI73915096, Length=528, Percent_Identity=33.1439393939394, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI73915094, Length=528, Percent_Identity=33.1439393939394, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI113429324, Length=536, Percent_Identity=31.9029850746269, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI113429326, Length=541, Percent_Identity=31.2384473197782, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI109148539, Length=546, Percent_Identity=32.4175824175824, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=28.4403669724771, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=28.3882783882784, Blast_Score=163, Evalue=5e-40,
Organism=Homo sapiens, GI153266907, Length=544, Percent_Identity=26.6544117647059, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=116, Evalue=8e-26,
Organism=Homo sapiens, GI218505805, Length=220, Percent_Identity=33.1818181818182, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI310124095, Length=220, Percent_Identity=31.3636363636364, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1789856, Length=577, Percent_Identity=58.4055459272097, Blast_Score=673, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=512, Percent_Identity=36.71875, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI212646519, Length=512, Percent_Identity=36.71875, Blast_Score=264, Evalue=9e-71,
Organism=Caenorhabditis elegans, GI17506189, Length=537, Percent_Identity=32.0297951582868, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17542894, Length=507, Percent_Identity=32.5443786982249, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI193208247, Length=549, Percent_Identity=30.6010928961749, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI193208245, Length=549, Percent_Identity=30.6010928961749, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17564448, Length=438, Percent_Identity=27.8538812785388, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI72001495, Length=228, Percent_Identity=28.0701754385965, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=28.0701754385965, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=559, Percent_Identity=28.4436493738819, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI161077496, Length=507, Percent_Identity=32.1499013806706, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI161077880, Length=549, Percent_Identity=31.6939890710383, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24642670, Length=548, Percent_Identity=31.5693430656934, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24642666, Length=548, Percent_Identity=31.5693430656934, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI161077878, Length=549, Percent_Identity=31.6939890710383, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI45551474, Length=548, Percent_Identity=31.5693430656934, Blast_Score=215, Evalue=7e-56,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=31.6602316602317, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI18859741, Length=540, Percent_Identity=28.8888888888889, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62048; Mature: 62048

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKIKGFIKSTCIALLPLYTFCAFAQAQTAAQAPRYDLTYDIISPVMGRNGMVASEQALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
SQVGLDILQRGGNAVDAAVAVGFALAVVLPNAGNIGGGGFMMIHDAKTGKNVALDFREMA
HHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCCCEEEEHHHCC
PAKASRDMYLDGQGNVVPGRSLHTHLAVGVPGTVAGLAHALQKYGTMKLSDVIAPAVELA
CCCCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHH
ETGYPVSPGLALILAEERAHLGQWESSKAIFFKDGRPLQAGERLVQKDLARSLELIGKQG
HCCCCCCCCEEEEEECCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PAAFYEGEIGQKIVAEMAQHQGLITSADLKNYKVIEREPVVGNYRGYQVVSMPPPSSGGV
CCCEECCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCC
HIIQMMNILERYPLQQYGANSAQTIHLKAEAMKRAYADRAEYLGDPDFTKVPVKGLTSRA
HHHHHHHHHHHCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
YADELAQKIDPERATPSSDIKPGKPLPHESDQTTHFSVADEKGNLVAATYTLNLNFGSGI
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCE
VAAGTGIMLNNEMDDFSAKPGVPNAFGLVGGDANAVGPGKRPLSSMSPTFVLKDGKPFLA
EECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEE
TGSPGGSRIITTTMQTILNVIDHDMNVAEAAVTPRIHHQWAPDQLRIEKGISADTLRILQ
ECCCCCCEEHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHHHCCCCHHHHHHHH
NKGQTISVQPAMGRTQTIQIKDGAFYGYSDPRNPDGRTLGF
CCCCEEEECCCCCCEEEEEEECCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MWKIKGFIKSTCIALLPLYTFCAFAQAQTAAQAPRYDLTYDIISPVMGRNGMVASEQALA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCHHHHHH
SQVGLDILQRGGNAVDAAVAVGFALAVVLPNAGNIGGGGFMMIHDAKTGKNVALDFREMA
HHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEECCCCCCEEEEHHHCC
PAKASRDMYLDGQGNVVPGRSLHTHLAVGVPGTVAGLAHALQKYGTMKLSDVIAPAVELA
CCCCCCCEEECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCEEHHHHHHHHHHHH
ETGYPVSPGLALILAEERAHLGQWESSKAIFFKDGRPLQAGERLVQKDLARSLELIGKQG
HCCCCCCCCEEEEEECCHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
PAAFYEGEIGQKIVAEMAQHQGLITSADLKNYKVIEREPVVGNYRGYQVVSMPPPSSGGV
CCCEECCCHHHHHHHHHHHHCCCEEECCCCCCEEEECCCCCCCCCCEEEEECCCCCCCCC
HIIQMMNILERYPLQQYGANSAQTIHLKAEAMKRAYADRAEYLGDPDFTKVPVKGLTSRA
HHHHHHHHHHHCCHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
YADELAQKIDPERATPSSDIKPGKPLPHESDQTTHFSVADEKGNLVAATYTLNLNFGSGI
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEEEEECCCCE
VAAGTGIMLNNEMDDFSAKPGVPNAFGLVGGDANAVGPGKRPLSSMSPTFVLKDGKPFLA
EECCCEEEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEE
TGSPGGSRIITTTMQTILNVIDHDMNVAEAAVTPRIHHQWAPDQLRIEKGISADTLRILQ
ECCCCCCEEHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCHHHHHCCCCHHHHHHHH
NKGQTISVQPAMGRTQTIQIKDGAFYGYSDPRNPDGRTLGF
CCCCEEEECCCCCCEEEEEEECCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]