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The map label for this gene is coaBC [H]

Identifier: 121609608

GI number: 121609608

Start: 2997670

End: 2998893

Strand: Direct

Name: coaBC [H]

Synonym: Veis_2654

Alternate gene names: 121609608

Gene position: 2997670-2998893 (Clockwise)

Preceding gene: 121609602

Following gene: 121609609

Centisome position: 53.85

GC content: 70.59

Gene sequence:

>1224_bases
ATGCACGAGCTTGCCGGCAAACACATCGTTTTGGGTCTGAGCGCCGGCGTGGCCTGTTACAAGGCGGCCGAACTGTGCCG
CCTGCTGGTCACCGAGGGGGCGAGCGTGCAGGTGGTGATGACCGAGGCGGCGCGGCAGTTCATCACCCCGGTGACCATGC
AGGCCCTGTCGGGGCGGCCGGTCTACGGCTCGCAGTGGGATGAGCGCGAGGGCGACGGCATGCCCCACATCCACCTGAGC
CGCAAGGCCGACGCGATGCTGATCGCGCCTTGCAGCGCCGACTTCGTTGCGCGCCTGGCGCAAGGCCGGGCGGACGAGTT
GCTCAGCCTGGCCTGCCTGGCCCGCCCGGCGCAGCGCGTGCCGCTGCTGCTGGCCCCGGCGATGAACCGCGAGATGTGGG
CCCACCCGGCCACCCGGCGCAATCTGGCCCAGGTGGTGCAAGACGGCGCGGTGGTGCTGGGCGTCGGCAGCGGCGAGCAA
GCCTGCGGCGAAACCGGTGCTGGCCGCATGCTGGAACCGCAGGAACTGCTCGACGAACTGCTGGCCTTCTTCGCCCCCAA
GCTGCTGGCCGGGCGCCGGCTGCTGGTGACGGCCGGGCCGACGTTCGAGGCCATGGACCCGGTGCGCGGCATCACCAACC
TGTCCAGCGGCAAGATGGGCTTTGCGCTGGCCCGCGCCGCCCGCGAAGCCGGGGCCGAGGTCACGCTGGTGGCCGGGCCG
GTGCATCTGACGACACCGCGCGGCGTGCGCCGGGTGGATGTGCAATCGGCGCAAGAAATGCTGGTCGCGGTCGAGCAGCA
TATCCAGGACGCCGGTGTTTTCATGGCCACGGCGGCGGTGGCCGATTGGCGGCCTGCGCAGCAGTCCGGGCGCAAGATCA
AAAAGGACGGCTCGGGGCAGCCGCCGGTGCTGGACTTTGTCGAAAACCCCGACATCCTGGCCACGCTGGCCCGGTCGGCG
CGCGCGCTCGAAGGAGCGCTGTTCTGTGTGGGTTTCTCGGCCGAAAGCCACGACCTGTTGGCCAATGCCACGGCCAAGCG
CGCGCGCAAGGGCGTGCCGTTGCTGGTGGGCAATATCGGCCCGGCCACCTTCGGCCGGGATGACAATGCCCTGCTGCTGG
TCGATGCCGATGGGCACCGCGAACTGCCCCGCGCCTCCAAGCGCGTGCTGGCGCAGCAACTGATCGCCGAGGTCGCAGCG
CGCTTGCCGCCGCTGCCGTCCTGA

Upstream 100 bases:

>100_bases
CGAATTTGGTCATATAAGGCCGTGGTAGAGCGCGATTATAGGAGGCGCTCCGGCGCCACCCGAGCGCCCCGGTGTGCCCG
CGTCTGCTAAATTGCGCCCC

Downstream 100 bases:

>100_bases
TGGCCGTCGCACAGCGGCTGCGGCAGACGGCCCGATGGCGCCCGGGCCGGCAACACAAGGAAACGAGCCAACGTGAAGAT
CGACATCAAGATTCTGGACC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MHELAGKHIVLGLSAGVACYKAAELCRLLVTEGASVQVVMTEAARQFITPVTMQALSGRPVYGSQWDEREGDGMPHIHLS
RKADAMLIAPCSADFVARLAQGRADELLSLACLARPAQRVPLLLAPAMNREMWAHPATRRNLAQVVQDGAVVLGVGSGEQ
ACGETGAGRMLEPQELLDELLAFFAPKLLAGRRLLVTAGPTFEAMDPVRGITNLSSGKMGFALARAAREAGAEVTLVAGP
VHLTTPRGVRRVDVQSAQEMLVAVEQHIQDAGVFMATAAVADWRPAQQSGRKIKKDGSGQPPVLDFVENPDILATLARSA
RALEGALFCVGFSAESHDLLANATAKRARKGVPLLVGNIGPATFGRDDNALLLVDADGHRELPRASKRVLAQQLIAEVAA
RLPPLPS

Sequences:

>Translated_407_residues
MHELAGKHIVLGLSAGVACYKAAELCRLLVTEGASVQVVMTEAARQFITPVTMQALSGRPVYGSQWDEREGDGMPHIHLS
RKADAMLIAPCSADFVARLAQGRADELLSLACLARPAQRVPLLLAPAMNREMWAHPATRRNLAQVVQDGAVVLGVGSGEQ
ACGETGAGRMLEPQELLDELLAFFAPKLLAGRRLLVTAGPTFEAMDPVRGITNLSSGKMGFALARAAREAGAEVTLVAGP
VHLTTPRGVRRVDVQSAQEMLVAVEQHIQDAGVFMATAAVADWRPAQQSGRKIKKDGSGQPPVLDFVENPDILATLARSA
RALEGALFCVGFSAESHDLLANATAKRARKGVPLLVGNIGPATFGRDDNALLLVDADGHRELPRASKRVLAQQLIAEVAA
RLPPLPS
>Mature_407_residues
MHELAGKHIVLGLSAGVACYKAAELCRLLVTEGASVQVVMTEAARQFITPVTMQALSGRPVYGSQWDEREGDGMPHIHLS
RKADAMLIAPCSADFVARLAQGRADELLSLACLARPAQRVPLLLAPAMNREMWAHPATRRNLAQVVQDGAVVLGVGSGEQ
ACGETGAGRMLEPQELLDELLAFFAPKLLAGRRLLVTAGPTFEAMDPVRGITNLSSGKMGFALARAAREAGAEVTLVAGP
VHLTTPRGVRRVDVQSAQEMLVAVEQHIQDAGVFMATAAVADWRPAQQSGRKIKKDGSGQPPVLDFVENPDILATLARSA
RALEGALFCVGFSAESHDLLANATAKRARKGVPLLVGNIGPATFGRDDNALLLVDADGHRELPRASKRVLAQQLIAEVAA
RLPPLPS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=34.6368715083799, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI87082301, Length=404, Percent_Identity=46.039603960396, Blast_Score=301, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=27.6041666666667, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=31.7460317460317, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43139; Mature: 43139

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELAGKHIVLGLSAGVACYKAAELCRLLVTEGASVQVVMTEAARQFITPVTMQALSGRP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCHHHHHHHCCCC
VYGSQWDEREGDGMPHIHLSRKADAMLIAPCSADFVARLAQGRADELLSLACLARPAQRV
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCHHHHC
PLLLAPAMNREMWAHPATRRNLAQVVQDGAVVLGVGSGEQACGETGAGRMLEPQELLDEL
CEEEECCCCCHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCCCCHHHHHHHH
LAFFAPKLLAGRRLLVTAGPTFEAMDPVRGITNLSSGKMGFALARAAREAGAEVTLVAGP
HHHHHHHHHCCCEEEEEECCCCHHHCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECC
VHLTTPRGVRRVDVQSAQEMLVAVEQHIQDAGVFMATAAVADWRPAQQSGRKIKKDGSGQ
EEECCCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCEECCCCCCC
PPVLDFVENPDILATLARSARALEGALFCVGFSAESHDLLANATAKRARKGVPLLVGNIG
CCEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCC
PATFGRDDNALLLVDADGHRELPRASKRVLAQQLIAEVAARLPPLPS
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHELAGKHIVLGLSAGVACYKAAELCRLLVTEGASVQVVMTEAARQFITPVTMQALSGRP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCHHHHHHHCCCC
VYGSQWDEREGDGMPHIHLSRKADAMLIAPCSADFVARLAQGRADELLSLACLARPAQRV
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHCHHHHC
PLLLAPAMNREMWAHPATRRNLAQVVQDGAVVLGVGSGEQACGETGAGRMLEPQELLDEL
CEEEECCCCCHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHCCCCCCCCCCHHHHHHHH
LAFFAPKLLAGRRLLVTAGPTFEAMDPVRGITNLSSGKMGFALARAAREAGAEVTLVAGP
HHHHHHHHHCCCEEEEEECCCCHHHCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECC
VHLTTPRGVRRVDVQSAQEMLVAVEQHIQDAGVFMATAAVADWRPAQQSGRKIKKDGSGQ
EEECCCCCCEEECHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCEECCCCCCC
PPVLDFVENPDILATLARSARALEGALFCVGFSAESHDLLANATAKRARKGVPLLVGNIG
CCEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCC
PATFGRDDNALLLVDADGHRELPRASKRVLAQQLIAEVAARLPPLPS
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]