Click here to switch to the map view.

The map label for this gene is groEL [H]

Identifier: 121609523

GI number: 121609523

Start: 2899922

End: 2901580

Strand: Direct

Name: groEL [H]

Synonym: Veis_2567

Alternate gene names: 121609523

Gene position: 2899922-2901580 (Clockwise)

Preceding gene: 121609522

Following gene: 121609527

Centisome position: 52.09

GC content: 64.32

Gene sequence:

>1659_bases
ATGGCAGCAAAAGAAGTGGTTTTCGGCGGCGAAGCCCGCGCTCGCATGGTCGAAGGCGTCAACATCCTGGCCAACGCGGT
CAAGGTGACCCTGGGCCCCAAGGGTCGCAATGTGGTGATCGAGCGCTCGTTCGGCGCCCCCACCGTGACCAAGGACGGCG
TGTCCGTGGCCAAGGAAATCGAGCTCAAGGACAAACTGCAGAACATGGGCGCGCAGTTGGTCAAGGAAGTGGCCTCCAAG
ACCAGCGACAACGCCGGTGACGGCACCACCACCGCCACCGTGCTGGCACAGGCCATCGTGCGCGAAGGCTTCAAGTACGT
GGCCGCCGGCATCAACCCGATGGACCTCAAGCGCGGTATCGACAAGGCCGTGACGGCGCTGGTGGCCGAACTGAAGAAGG
CGTCCAAGCCCACCACCACCTCCAAGGAAATCGCCCAGGTCGGCTCGATCTCGGCCAACGCCGACGAGACCATTGGCAAA
CTGATCGCTGACGCGATGGACAAGGTGGGCAAGGAAGGCGTGATCACCGTGGAAGACGGCAAGTCGCTCGAATCCGAACT
CGATGTCGTCGAAGGCATGCAGTTCGATCGCGGCTACCTGTCGCCCTACTTCATCAACAACCCGGACAAGCAAGCGGCCC
TTCTGGACAACCCCTTCGTGCTGCTGTTCGACAAGAAGATCAGCAACATCCGCGACCTGCTGCCCACGCTGGAGCAGGTG
GCCAAGGCGGGCCGTCCGCTGCTGGTCATTGCCGAAGAAGTCGAGGGCGAAGCCCTGGCGACGCTGGTGGTGAACACGAT
CCGCGGCATCCTGAAGGTGGTGGCCGTGAAGGCCCCCGGTTTCGGCGACCGCCGCAAGGCCATGCTGGAAGACATCGCCA
TCCTGACGGGCGGCAAGGTCATCGCTGAAGAAGTGGGCCTGACCCTGGAGAAAGTGACGCTGGCCGATCTGGGCCAAGCC
AAGCGCATCGAAGTGGGCAAGGAAAACACCATCATCATCGACGGCGCCGGTGCCGCTGGCGACATCGAAGCCCGCGTCAA
GCAAGTGCGCGTGCAGATCGAGGAAGCCACCTCCGACTACGACCGCGAAAAGCTGCAAGAGCGCGTGGCCAAACTGGCCG
GCGGTGTGGCCGTGATCAAGGTCGGCGCAGCCACCGAAGTCGAAATGAAGGAAAAGAAGGCCCGCGTCGAAGACGCGCTG
CACGCAACCCGCGCAGCGGTGGAAGAAGGCGTGGTCGCCGGTGGTGGCGTGGCCTTCCTGCGCGCCAGGCAGGCCATTGG
CGGCACCATCAAGGGTGACAACGCCGACCAGGACGCCGGCATCAAGCTGGTGCTCAAGGCCATCGAAGCGCCGCTGCGCG
AAATCGTGAACAACGCCGGTGGCGAAGCCTCGGTGGTGGTCAACGCGGTGCTGGCCGGCAAGGGCAACTATGGCTTCAAT
GCAGCCAACGACACCTACGGCGACATGCTGGAGCTGGGCATTCTCGACCCCACCAAGGTCACCCGCACGGCCCTGCAGAA
CGCCGCTTCGGTGGCCTCGCTGCTGCTGACGACCGAGGCCATGGTGGCCGAAGCGCCGAAGGACGATGCGCCTGCCGGCG
GTGGCGGCATGCCTGGCATGGGCGGCGGCATGGGTGGCATGGGCGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
CGAGTTGCTGGTCATGAAGGAAGACGATCTGTTTGCCGTGGTCGAGAAGTAATTCCGCCCCGTTCCCAAGCAGACTTTTT
ACTCAATTCGGAGATATCAA

Downstream 100 bases:

>100_bases
CTGCCAGATCGGTGTGCCCGCGCAGGCACACTGCGCCCAACGAAAGCCCGCAGGTCTTACGGCCTGCGGGCTTTTTCAAT
GGGGCTTCATTTCTCGTGCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MAAKEVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVIERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASK
TSDNAGDGTTTATVLAQAIVREGFKYVAAGINPMDLKRGIDKAVTALVAELKKASKPTTTSKEIAQVGSISANADETIGK
LIADAMDKVGKEGVITVEDGKSLESELDVVEGMQFDRGYLSPYFINNPDKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
AKAGRPLLVIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRIEVGKENTIIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVAFLRARQAIGGTIKGDNADQDAGIKLVLKAIEAPLREIVNNAGGEASVVVNAVLAGKGNYGFN
AANDTYGDMLELGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAGGGGMPGMGGGMGGMGGMDM

Sequences:

>Translated_552_residues
MAAKEVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVIERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASK
TSDNAGDGTTTATVLAQAIVREGFKYVAAGINPMDLKRGIDKAVTALVAELKKASKPTTTSKEIAQVGSISANADETIGK
LIADAMDKVGKEGVITVEDGKSLESELDVVEGMQFDRGYLSPYFINNPDKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
AKAGRPLLVIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQA
KRIEVGKENTIIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVAFLRARQAIGGTIKGDNADQDAGIKLVLKAIEAPLREIVNNAGGEASVVVNAVLAGKGNYGFN
AANDTYGDMLELGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAGGGGMPGMGGGMGGMGGMDM
>Mature_551_residues
AAKEVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVIERSFGAPTVTKDGVSVAKEIELKDKLQNMGAQLVKEVASKT
SDNAGDGTTTATVLAQAIVREGFKYVAAGINPMDLKRGIDKAVTALVAELKKASKPTTTSKEIAQVGSISANADETIGKL
IADAMDKVGKEGVITVEDGKSLESELDVVEGMQFDRGYLSPYFINNPDKQAALLDNPFVLLFDKKISNIRDLLPTLEQVA
KAGRPLLVIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKVIAEEVGLTLEKVTLADLGQAK
RIEVGKENTIIIDGAGAAGDIEARVKQVRVQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVAGGGVAFLRARQAIGGTIKGDNADQDAGIKLVLKAIEAPLREIVNNAGGEASVVVNAVLAGKGNYGFNA
ANDTYGDMLELGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAGGGGMPGMGGGMGGMGGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.8409090909091, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.8409090909091, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI5453607, Length=558, Percent_Identity=24.3727598566308, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=73.9622641509434, Blast_Score=777, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=53.4839924670433, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI193210679, Length=223, Percent_Identity=50.2242152466368, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17564182, Length=563, Percent_Identity=22.9129662522202, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=53.1309297912713, Blast_Score=539, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322350, Length=570, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322446, Length=562, Percent_Identity=21.5302491103203, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322524, Length=388, Percent_Identity=23.4536082474227, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.4621212121212, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.4621212121212, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=50.4761904761905, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=50.4761904761905, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=50.4761904761905, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=44.4043321299639, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=526, Percent_Identity=37.4524714828897, Blast_Score=338, Evalue=8e-93,
Organism=Drosophila melanogaster, GI19921262, Length=526, Percent_Identity=37.4524714828897, Blast_Score=338, Evalue=8e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57447; Mature: 57316

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVIERSFGAPTVTKDGVSVAKEI
CCCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQLVKEVASKTSDNAGDGTTTATVLAQAIVREGFKYVAAGINPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
DKAVTALVAELKKASKPTTTSKEIAQVGSISANADETIGKLIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
KSLESELDVVEGMQFDRGYLSPYFINNPDKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLVIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRIEVGKENTIIIDGAGAAGDIEARVKQVRVQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVAFL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARQAIGGTIKGDNADQDAGIKLVLKAIEAPLREIVNNAGGEASVVVNAVLAGKGNYGFN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCCCC
AANDTYGDMLELGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAGGGGMPGM
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGGMGGMGGMDM
CCCCCCCCCCCC
>Mature Secondary Structure 
AAKEVVFGGEARARMVEGVNILANAVKVTLGPKGRNVVIERSFGAPTVTKDGVSVAKEI
CCCCEEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHH
ELKDKLQNMGAQLVKEVASKTSDNAGDGTTTATVLAQAIVREGFKYVAAGINPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHH
DKAVTALVAELKKASKPTTTSKEIAQVGSISANADETIGKLIADAMDKVGKEGVITVEDG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCC
KSLESELDVVEGMQFDRGYLSPYFINNPDKQAALLDNPFVLLFDKKISNIRDLLPTLEQV
CCHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECHHHHHHHHHHHHHHHH
AKAGRPLLVIAEEVEGEALATLVVNTIRGILKVVAVKAPGFGDRRKAMLEDIAILTGGKV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
IAEEVGLTLEKVTLADLGQAKRIEVGKENTIIIDGAGAAGDIEARVKQVRVQIEEATSDY
HHHHHCCCHHEEHHHHCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVAFL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RARQAIGGTIKGDNADQDAGIKLVLKAIEAPLREIVNNAGGEASVVVNAVLAGKGNYGFN
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEEECCCCCCCC
AANDTYGDMLELGILDPTKVTRTALQNAASVASLLLTTEAMVAEAPKDDAPAGGGGMPGM
CCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GGGMGGMGGMDM
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA