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The map label for this gene is yisK [H]

Identifier: 121609366

GI number: 121609366

Start: 2723924

End: 2724799

Strand: Direct

Name: yisK [H]

Synonym: Veis_2409

Alternate gene names: 121609366

Gene position: 2723924-2724799 (Clockwise)

Preceding gene: 121609365

Following gene: 121609367

Centisome position: 48.93

GC content: 68.61

Gene sequence:

>876_bases
ATGAAACTCATCAGCTACCTCCACGGCGGGGCCTCGCACTGGGGCTGCGTCATCGGCGACGGCGTCGTCGATCTCGGCCG
CCGCCTGCCGGCCTGCGCGTGCGTCGCGGCATTGCTCGAAGGCGGCGACGCCGCGCTCGCGCAGGCGCGCCAGGCCGCAG
AGGGCGCCGCGCCCGACCATGCGCTGGCCGATGTGCGGTTCCAGACGCCCATCGCGCGGCCACGCCGCGTGTTCTGCATC
GGCGTGAACTACGCGCACCGCAACGCCGAATACAAGGACGGCAGCGATTCGCCCAAGTACCCGAGCATCTTCATGCGCGT
GGCCGAGTCCTTCGTCGGCCACGGCGAGCCGTTGCAGCAGCCGCTCGAATCGACACAGCTCGACTACGAGGGCGAGATCG
CCATCGTCATCGGCCAGCGCGCGCGCCGCGTGCAGGCAGACGACGCGCTGGCCTGCATCGCCGGAATCACCTGCATGAAC
GAAGGCACCGTCCGCGACTGGACGCACCACGCCAAGTTCAACGTGACGCAGGGCAAGAACTGGAATGCGTCCGGCGCCAT
CGGCCCGTGGATCGTCACGGCCGACGAATTTCCGCAGGGCTATGGCGCGCTGCGCGTGCGCACGCATGTCAATGGCGAAC
TGCGGCAGGACGACAGCAGCGCGAACCTGATGTTCGGCTTCGCCTGCCTCGTCAACTACCTCTCGACCTTCACCACGCTG
GCGCCGGGCGACATCATCGCCACCGGCACGCCGATCGGCGCGGGCATCCGCTTCGATCCGCCGAAGTTCCTGCGGCCGGG
CGATGTGGTCGAGATCGAAGTCAGCGGCGTGGGCGTGCTGCGCAACGTCGTGAAGGCCGAAGAGGTGGCGCCATGA

Upstream 100 bases:

>100_bases
GCGCATTGCTCGAACTGCTCTATCGCTTCGCCCCCGACGCCGCCACGCGGCAGAAGATCCTTGTCGACAACCCCGCCCGC
CTCTTTGGATTCGACAGCGC

Downstream 100 bases:

>100_bases
AACGACATCCTGTGTTAGCCCGGTGTTTTTGCTTGCCTGCGGCCTCGACCGGCAGGAGGGTAGTCCGGTGAGCCTGGACC
AGAACACCCTCGCCCAGGCC

Product: 5-carboxymethyl-2-hydroxymuconate delta-isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKLISYLHGGASHWGCVIGDGVVDLGRRLPACACVAALLEGGDAALAQARQAAEGAAPDHALADVRFQTPIARPRRVFCI
GVNYAHRNAEYKDGSDSPKYPSIFMRVAESFVGHGEPLQQPLESTQLDYEGEIAIVIGQRARRVQADDALACIAGITCMN
EGTVRDWTHHAKFNVTQGKNWNASGAIGPWIVTADEFPQGYGALRVRTHVNGELRQDDSSANLMFGFACLVNYLSTFTTL
APGDIIATGTPIGAGIRFDPPKFLRPGDVVEIEVSGVGVLRNVVKAEEVAP

Sequences:

>Translated_291_residues
MKLISYLHGGASHWGCVIGDGVVDLGRRLPACACVAALLEGGDAALAQARQAAEGAAPDHALADVRFQTPIARPRRVFCI
GVNYAHRNAEYKDGSDSPKYPSIFMRVAESFVGHGEPLQQPLESTQLDYEGEIAIVIGQRARRVQADDALACIAGITCMN
EGTVRDWTHHAKFNVTQGKNWNASGAIGPWIVTADEFPQGYGALRVRTHVNGELRQDDSSANLMFGFACLVNYLSTFTTL
APGDIIATGTPIGAGIRFDPPKFLRPGDVVEIEVSGVGVLRNVVKAEEVAP
>Mature_291_residues
MKLISYLHGGASHWGCVIGDGVVDLGRRLPACACVAALLEGGDAALAQARQAAEGAAPDHALADVRFQTPIARPRRVFCI
GVNYAHRNAEYKDGSDSPKYPSIFMRVAESFVGHGEPLQQPLESTQLDYEGEIAIVIGQRARRVQADDALACIAGITCMN
EGTVRDWTHHAKFNVTQGKNWNASGAIGPWIVTADEFPQGYGALRVRTHVNGELRQDDSSANLMFGFACLVNYLSTFTTL
APGDIIATGTPIGAGIRFDPPKFLRPGDVVEIEVSGVGVLRNVVKAEEVAP

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=292, Percent_Identity=34.2465753424658, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI40786394, Length=290, Percent_Identity=33.7931034482759, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI215422413, Length=184, Percent_Identity=29.8913043478261, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI13654274, Length=184, Percent_Identity=29.8913043478261, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI66348062, Length=184, Percent_Identity=29.8913043478261, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1787428, Length=214, Percent_Identity=28.0373831775701, Blast_Score=81, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17557057, Length=200, Percent_Identity=29.5, Blast_Score=88, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324161, Length=239, Percent_Identity=26.3598326359833, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28572127, Length=291, Percent_Identity=31.6151202749141, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24663695, Length=223, Percent_Identity=32.2869955156951, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28571789, Length=217, Percent_Identity=28.110599078341, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 31154; Mature: 31154

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLISYLHGGASHWGCVIGDGVVDLGRRLPACACVAALLEGGDAALAQARQAAEGAAPDH
CCHHHHHCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
ALADVRFQTPIARPRRVFCIGVNYAHRNAEYKDGSDSPKYPSIFMRVAESFVGHGEPLQQ
HHHCEEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
PLESTQLDYEGEIAIVIGQRARRVQADDALACIAGITCMNEGTVRDWTHHAKFNVTQGKN
HHHHCCCCCCCCEEEEECCCCHHCCCCHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCC
WNASGAIGPWIVTADEFPQGYGALRVRTHVNGELRQDDSSANLMFGFACLVNYLSTFTTL
CCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHC
APGDIIATGTPIGAGIRFDPPKFLRPGDVVEIEVSGVGVLRNVVKAEEVAP
CCCCEEECCCCCCCCCEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLISYLHGGASHWGCVIGDGVVDLGRRLPACACVAALLEGGDAALAQARQAAEGAAPDH
CCHHHHHCCCCCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
ALADVRFQTPIARPRRVFCIGVNYAHRNAEYKDGSDSPKYPSIFMRVAESFVGHGEPLQQ
HHHCEEECCCCCCCCEEEEEEECHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
PLESTQLDYEGEIAIVIGQRARRVQADDALACIAGITCMNEGTVRDWTHHAKFNVTQGKN
HHHHCCCCCCCCEEEEECCCCHHCCCCHHHHHHHHHEECCCCCCCCCCCCCEEEECCCCC
WNASGAIGPWIVTADEFPQGYGALRVRTHVNGELRQDDSSANLMFGFACLVNYLSTFTTL
CCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHC
APGDIIATGTPIGAGIRFDPPKFLRPGDVVEIEVSGVGVLRNVVKAEEVAP
CCCCEEECCCCCCCCCEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]