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The map label for this gene is fabG [C]

Identifier: 121609345

GI number: 121609345

Start: 2701778

End: 2702683

Strand: Direct

Name: fabG [C]

Synonym: Veis_2388

Alternate gene names: 121609345

Gene position: 2701778-2702683 (Clockwise)

Preceding gene: 121609337

Following gene: 121609346

Centisome position: 48.53

GC content: 64.13

Gene sequence:

>906_bases
ATGGTTGAAGGAAAAGCAGTGGTCGTCACCGGCGCGGGCGGTGGCATAGGGCGCGCCATCGCGTTGGCAATGGCGCAGCA
TGGCGCGCGCGTCGTGGTCAACGACATCGGCGCTGCCGTTGACGGCGCAGGTCGCGACGCGGGGCCTGCGCAACAGGTGG
TCGATGAGATTCGGGCGCTGGGCGGGCACGCGGTTGCCAACACCGACAATGTGGCTGACGCTGCCAGCGCGACGCGGATC
ATCGGGTGCGCGCTCGACAGCTTTGGCCGCATCGACGCGGTGGTGAACAACGCCGGCATCCTGCGCGACCGTTTCTTTCA
CAAGATGTCCGTCGATGAGTGGGACTCGGTGATCAAGGTCCATCTCTATGGCAGCTACCATGTCAGTCGCGCGGCAGCGG
TGTTTTTCAAGGAGCAAGGCTCGGGCGCCATGGTGCACATGACCTCGACCTCGGGCCTCATCGGCAACTTCGGGCAGGCC
AACTATGCGGCAGCGAAGCTGGGCATTGCGGCGCTGTCCAAGTCGATCGCGCTGGACATGCTCAAGTTCAACGTCCGTTC
CAACTGCATTGCCCCCTTCGCATGGAGCCGCATGATAGGTTCCATCCCGACCGACACCGAGGAGCAGCGTGTGCGTGTCG
ACAAGATCCGGCAGATGACGCCGGCCAAGATCGCGCCGCTGGCCGTCTACCTGATCAGCGATGCGGCCAGGGAGGTCAAT
GGCCAGATCTTCTCGGTGCGCAACAACGAGATCTCGCTGATCAGCCAGCCGCGCCCGTTGCGTTCCATCCATCGCTCCGA
GGGCTGGACGCCGCAGGCCATCGCCGAGCATGCGATGCCGGCGTTGCGCGCCAGTTTCTTTGCGTTGGACCGCTCGGCGG
ATGTCTTCAGTTGGGATCCGGTCTGA

Upstream 100 bases:

>100_bases
TCCGTTTGCTCAAACCCCCTCTTTGGCAAGGAAGAAATGGCAGGTGCCGAGGCTATGGCATCCTTGCCCCGATCGAGCAC
GCAAGCGTTGGAGTCGCCTT

Downstream 100 bases:

>100_bases
GGTTTGCGGGACAAATTGCAGGACAATCGGGCCTTGTGAGGCCCTTGTGAATCTGCATTTCGACCTGTTTGATTTGAAAC
TCTTCACCTACGTGGCTGAG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MVEGKAVVVTGAGGGIGRAIALAMAQHGARVVVNDIGAAVDGAGRDAGPAQQVVDEIRALGGHAVANTDNVADAASATRI
IGCALDSFGRIDAVVNNAGILRDRFFHKMSVDEWDSVIKVHLYGSYHVSRAAAVFFKEQGSGAMVHMTSTSGLIGNFGQA
NYAAAKLGIAALSKSIALDMLKFNVRSNCIAPFAWSRMIGSIPTDTEEQRVRVDKIRQMTPAKIAPLAVYLISDAAREVN
GQIFSVRNNEISLISQPRPLRSIHRSEGWTPQAIAEHAMPALRASFFALDRSADVFSWDPV

Sequences:

>Translated_301_residues
MVEGKAVVVTGAGGGIGRAIALAMAQHGARVVVNDIGAAVDGAGRDAGPAQQVVDEIRALGGHAVANTDNVADAASATRI
IGCALDSFGRIDAVVNNAGILRDRFFHKMSVDEWDSVIKVHLYGSYHVSRAAAVFFKEQGSGAMVHMTSTSGLIGNFGQA
NYAAAKLGIAALSKSIALDMLKFNVRSNCIAPFAWSRMIGSIPTDTEEQRVRVDKIRQMTPAKIAPLAVYLISDAAREVN
GQIFSVRNNEISLISQPRPLRSIHRSEGWTPQAIAEHAMPALRASFFALDRSADVFSWDPV
>Mature_301_residues
MVEGKAVVVTGAGGGIGRAIALAMAQHGARVVVNDIGAAVDGAGRDAGPAQQVVDEIRALGGHAVANTDNVADAASATRI
IGCALDSFGRIDAVVNNAGILRDRFFHKMSVDEWDSVIKVHLYGSYHVSRAAAVFFKEQGSGAMVHMTSTSGLIGNFGQA
NYAAAKLGIAALSKSIALDMLKFNVRSNCIAPFAWSRMIGSIPTDTEEQRVRVDKIRQMTPAKIAPLAVYLISDAAREVN
GQIFSVRNNEISLISQPRPLRSIHRSEGWTPQAIAEHAMPALRASFFALDRSADVFSWDPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=274, Percent_Identity=44.5255474452555, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI15277342, Length=225, Percent_Identity=35.5555555555556, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=27.2, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI40254992, Length=209, Percent_Identity=30.622009569378, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=23.7547892720307, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4503817, Length=190, Percent_Identity=26.8421052631579, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542939, Length=260, Percent_Identity=28.8461538461538, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI59889578, Length=180, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4758504, Length=217, Percent_Identity=28.110599078341, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=34.7826086956522, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=32.258064516129, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=31.0756972111554, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=27.6, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=28.3400809716599, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=26.9076305220884, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=29.2490118577075, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787526, Length=266, Percent_Identity=24.812030075188, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=29.0196078431373, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788459, Length=241, Percent_Identity=27.3858921161826, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789057, Length=230, Percent_Identity=27.8260869565217, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=242, Percent_Identity=42.9752066115703, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25147288, Length=255, Percent_Identity=34.5098039215686, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=32.2709163346614, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=24.5967741935484, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=27.6923076923077, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=221, Percent_Identity=26.6968325791855, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=199, Percent_Identity=28.643216080402, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=193, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=25.3886010362694, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=25.3846153846154, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=27.6381909547739, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=197, Percent_Identity=25.8883248730964, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=179, Percent_Identity=25.1396648044693, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=216, Percent_Identity=26.3888888888889, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=26.3959390862944, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=198, Percent_Identity=24.7474747474747, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=200, Percent_Identity=27.5, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=26.0700389105058, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=242, Percent_Identity=44.6280991735537, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324126, Length=263, Percent_Identity=27.7566539923954, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18859837, Length=236, Percent_Identity=42.7966101694915, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=34.9593495934959, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=30, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI23397609, Length=189, Percent_Identity=30.6878306878307, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571526, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=228, Percent_Identity=25, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356301, Length=176, Percent_Identity=28.9772727272727, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737361, Length=216, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24580925, Length=214, Percent_Identity=28.0373831775701, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281364892, Length=197, Percent_Identity=25.8883248730964, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=190, Percent_Identity=25.2631578947368, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32010; Mature: 32010

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00061 ADH_SHORT ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEGKAVVVTGAGGGIGRAIALAMAQHGARVVVNDIGAAVDGAGRDAGPAQQVVDEIRAL
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHH
GGHAVANTDNVADAASATRIIGCALDSFGRIDAVVNNAGILRDRFFHKMSVDEWDSVIKV
CCCEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHCCEEEE
HLYGSYHVSRAAAVFFKEQGSGAMVHMTSTSGLIGNFGQANYAAAKLGIAALSKSIALDM
EEECCHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LKFNVRSNCIAPFAWSRMIGSIPTDTEEQRVRVDKIRQMTPAKIAPLAVYLISDAAREVN
HHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GQIFSVRNNEISLISQPRPLRSIHRSEGWTPQAIAEHAMPALRASFFALDRSADVFSWDP
CEEEEEECCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCC
V
C
>Mature Secondary Structure
MVEGKAVVVTGAGGGIGRAIALAMAQHGARVVVNDIGAAVDGAGRDAGPAQQVVDEIRAL
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCHHHHHHHHHHHH
GGHAVANTDNVADAASATRIIGCALDSFGRIDAVVNNAGILRDRFFHKMSVDEWDSVIKV
CCCEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCHHHHCCEEEE
HLYGSYHVSRAAAVFFKEQGSGAMVHMTSTSGLIGNFGQANYAAAKLGIAALSKSIALDM
EEECCHHHHHHEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LKFNVRSNCIAPFAWSRMIGSIPTDTEEQRVRVDKIRQMTPAKIAPLAVYLISDAAREVN
HHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
GQIFSVRNNEISLISQPRPLRSIHRSEGWTPQAIAEHAMPALRASFFALDRSADVFSWDP
CEEEEEECCCEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]