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The map label for this gene is kgtP [H]

Identifier: 121639394

GI number: 121639394

Start: 3872580

End: 3873929

Strand: Reverse

Name: kgtP [H]

Synonym: BCG_3539c

Alternate gene names: 121639394

Gene position: 3873929-3872580 (Counterclockwise)

Preceding gene: 121639399

Following gene: 121639393

Centisome position: 88.56

GC content: 59.85

Gene sequence:

>1350_bases
ATGACCGTTTCCATTGCACCTCCATCGCGCCCGAGTCAGGCCGAGACCCGTCGGGCCATTTGGAACACGATCCGGGGATC
GTCGGGCAATCTGGTCGAGTGGTATGACGTCTACGTCTACACCGTGTTCGCTACGTATTTCGAGGACCAATTCTTTGATC
GGGCCGATCGCAACTCGACGGTCTATGTCTACGCGATCTTCGCTGTTACCTTCGTGACCCGGCCCGTCGGATCGTGGTTC
TTTGGTCGGTTTGCCGACCGCCGCGGCCGCCGGGCCGCGCTGACGTTCAGTGTGTCGCTGATGGCCGCCTGTTCGCTGAT
CGTGGCGTTGGTGCCGTCTCGCTCGAGCATTGGCGTCGCTGCGCCGATCCTGCTTATTTTGTGTCGGCTCGTCCAGGGAT
TTGCGACCGGCGGAGAGTACGGCACGTCGGTGACGTACATGTCTGAGGCCGCGACGCGGGAGCGGCGCGGCTACTTCTCG
TCGTTTCAGTATGTGACGCTGGTGGGTGGGCACGTGCTTGCCCAGTTCACCCTGCTAGTCATCCTGGCGGTCTTCACCCG
CGAGCAGGTTCACGAATTCGGCTGGCGCATCGGCTTCGCCGTAGGCGGTGGCGCCGCGATCGTGGTGTTCTGGTTGCGGC
GCACGATGGATGAATCGCTCAGTCAGGAACGCCTGACTGCGATCAAGGCCGGGCGGGACCACGACTCCGGGTCGCTCCGT
GAACTGGCCACCCACTATTGGAAGCCATTGCTGCTCTGTTTCCTCGTCACGTTGGGCGGCACGGTCGCGTTTTATACCTA
CAGCGTCAATGCACCTGCGATCGTCAAGAGTGTCTACGGTTCGCAGGCGATGACCGCTACTTGGATCAACCTGGTTGGTC
TGATTCTGTTGATGATGCTGCAGCCCATCGGGGGCATGATCAGCGACAAGATCGGCCGCAAGCCACTGCTGCTGTGGTTC
GGCGTCGGCGGACTCATCTATACCTACGTCCTTGTTACTTATCTTCCCGAAACACGTTCGCCGACAATGTCGTTTCTATT
GGTGGCCGTCGGCTATGTGATTCTGACCGGATACTGCTCGATCAATGCACTGGTCAAGTCCGAACTGTTCCCCGCGCACG
TGCGCGCCCTTGGTGTCGGAGTCGGCTATGCACTGGCGAACTCGGTCTTCGGCGGCACCGCGCCGCTGATCTACCAGGCT
CTTAAGGAACGCGATCAGGTGCCGATGTTCATCGCCTACGTGACCGCGTGCATAGCGGTCTCGCTGATTGTCTATGTGTT
TTTCATCAAGAACAAGGCCGATACCTACCTCGACCGCGAGCAGGGATTTGCATTCTACGGGCACGCATAG

Upstream 100 bases:

>100_bases
TCAAAACCGACCACGCTCCAGCCCTGCACGGCGGGTGCTGACGTCGGTCACTATGGTGACCGTCAGACGGCGCGACAATG
CGAATCGCATGGAGGACACC

Downstream 100 bases:

>100_bases
CTGTAGCGTCTGGGTAACACCTTTCGCCGAGCGTGCAATCACTGCGAAAATGGCGCCTTGGGTTCCGTGGATGGACCACG
AACCGGGTGCCGGATTGACG

Product: putative dicarboxylic acid transport integral membrane protein kgtP

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWF
FGRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFS
SFQYVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLR
ELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWF
GVGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQA
LKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA

Sequences:

>Translated_449_residues
MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWF
FGRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFS
SFQYVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLR
ELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWF
GVGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQA
LKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA
>Mature_448_residues
TVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWFF
GRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFSS
FQYVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLRE
LATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFG
VGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQAL
KERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=422, Percent_Identity=40.0473933649289, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1790550, Length=430, Percent_Identity=27.4418604651163, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1788292, Length=412, Percent_Identity=27.9126213592233, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789941, Length=406, Percent_Identity=27.0935960591133, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI87082231, Length=222, Percent_Identity=28.3783783783784, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082404, Length=338, Percent_Identity=24.8520710059172, Blast_Score=69, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 49579; Mature: 49448

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNST
CEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VYVYAIFAVTFVTRPVGSWFFGRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVA
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHH
APILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFSSFQYVTLVGGHVLAQFTLLV
HHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHH
ILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLR
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMML
HHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCS
HHHCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
INALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQALKERDQVPMFIAYVTACIAV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SLIVYVFFIKNKADTYLDREQGFAFYGHA
HHHHHHHHHCCCHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
TVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNST
EEECCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VYVYAIFAVTFVTRPVGSWFFGRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVA
EEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCHH
APILLILCRLVQGFATGGEYGTSVTYMSEAATRERRGYFSSFQYVTLVGGHVLAQFTLLV
HHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHHHHHH
ILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLR
HHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
ELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMML
HHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCS
HHHCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
INALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQALKERDQVPMFIAYVTACIAV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SLIVYVFFIKNKADTYLDREQGFAFYGHA
HHHHHHHHHCCCHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]