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The map label for this gene is rmld [H]

Identifier: 121639155

GI number: 121639155

Start: 3599366

End: 3600280

Strand: Reverse

Name: rmld [H]

Synonym: BCG_3295c

Alternate gene names: 121639155

Gene position: 3600280-3599366 (Counterclockwise)

Preceding gene: 121639160

Following gene: 121639154

Centisome position: 82.3

GC content: 69.18

Gene sequence:

>915_bases
ATGGCGGGCAGGTCAGAAAGGCTAGTCATCACCGGTGCGGGCGGGCAGCTGGGCAGCCATCTGACGGCACAGGCCGCCCG
GGAAGGCCGCGATATGCTGGCGCTGACTTCCTCGCAGTGGGATATCACCGACCCCGCTGCGGCCGAGCGGATCATCCGAC
ACGGTGACGTGGTGATCAATTGCGCCGCCTACACCGACGTCGACGGCGCCGAGAGCAATGAGGCAGTCGCCTATGCGGTC
AATGCCACTGGCCCGCAACACCTCGCCCGTGCGTGCGCTCGTGTGGGTGCTCGGTTAATCCACGTCTCCACCGACTACGT
ATTCGATGGCGACTTCGGCGGCGCCGAGCCCCGGCCCTACGAGCCCACCGATGAAACCGCGCCGCAGGGCGTGTATGCCC
GCAGCAAACTCGCCGGCGAGCAGGCTGTGCTGGCAGCGTTCCCGGAGGCTGCCGTGGTACGGACCGCCTGGGTCTACACC
GGCGGGACCGGCAAGGATTTCGTCGCCGTCATGCGCCGGCTGGCCGCCGGACACGGTCGGGTGGATGTGGTCGACGACCA
GACCGGGTCGCCGACCTACGTCGCCGACCTGGCCGAGGCGCTGCTGGCGTTGGCCGACGCGGGCGTGCGCGGACGCGTGT
TGCACGCCGCTAACGAGGGCGTGGTCTCCCGGTTCGGTCAAGCCCGCGCGGTGTTCGAAGAATGCGGTGCCGACCCACAG
CGGGTGCGTCCGGTCAGCAGCGCGCAGTTTCCGCGGCCCGCGCCGCGTCCGAGCTATTCCGCGCTGTCGAGCAGGCAGTG
GGCGCTGGCGGGCTTGACGCCGCTACGGCACTGGCGCAGCGCACTGGCCACGGCGCTGGCAGCACCTGCGAACTCAACTT
CGATCGATCGACGGTTACCCTCAACGCGTGACTGA

Upstream 100 bases:

>100_bases
GAACCACACGTTGCGCAGACATCACACTAGACTACTTGTGTAACGGCGCCCTGTCGGGTAGCCAACCCCGGCGTGCCCGA
GGCGTGCCAGACTCAAACAC

Downstream 100 bases:

>100_bases
CGTCCTGCCGGTGGTAGCGGTGACCTACTCGCCGGGGCCCCATCTAGAGCGGTTCCTGGCGTCGTTGTCGCTGGCCACCG
AGCGGCCGGTCAGCGTGCTG

Product: putative dTDP-rhamnose modification protein rmlD

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAV
NATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYT
GGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
RVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD

Sequences:

>Translated_304_residues
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAV
NATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYT
GGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
RVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD
>Mature_303_residues
AGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVN
ATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTG
GTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQR
VRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=292, Percent_Identity=27.7397260273973, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI11034825, Length=292, Percent_Identity=27.7397260273973, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1788352, Length=305, Percent_Identity=32.4590163934426, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 32055; Mature: 31924

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVIN
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
CAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPY
EEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEECEEECCCCCCCCCCCC
EPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGR
CCCCCCCCCCHHHHHHHCCCHHHHHHCCCHHHEEEEEEEECCCCHHHHHHHHHHHCCCCC
VDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHH
RVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLP
HCCCCCCCCCCCCCCCCCHHHHCCCCEEHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCC
STRD
CCCC
>Mature Secondary Structure 
AGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVIN
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
CAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPY
EEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCEEEEEEECEEECCCCCCCCCCCC
EPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGR
CCCCCCCCCCHHHHHHHCCCHHHHHHCCCHHHEEEEEEEECCCCHHHHHHHHHHHCCCCC
VDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQ
EEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCHH
RVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLP
HCCCCCCCCCCCCCCCCCHHHHCCCCEEHHCCHHHHHHHHHHHHHHHCCCCCCHHHHCCC
STRD
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]