Definition Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession NC_008769
Length 4,374,522

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The map label for this gene is nudC

Identifier: 121639084

GI number: 121639084

Start: 3524084

End: 3525025

Strand: Reverse

Name: nudC

Synonym: BCG_3224c

Alternate gene names: 121639084

Gene position: 3525025-3524084 (Counterclockwise)

Preceding gene: 121639085

Following gene: 121639082

Centisome position: 80.58

GC content: 66.67

Gene sequence:

>942_bases
GTGACGAACGTAAGCGGCGTGGATTTTCAGCTGAGAAGCGTTCCGTTGCTTTCGCGCGTCGGCGCCGACCGGGCCGACCG
GCTGAGGACCGACATGGAGGCGGCCGCCGCGGGATGGCCAGGCGCGGCATTGCTGCGGGTGGATTCCCGCAATCGCGTGC
TGGTCGCCAACGGCCGGGTGTTGCTTGGCGCGGCCATCGAGCTGGCCGACAAGCCACCGCCAGAGGCGGTATTCCTGGGT
CGCGTCGAGGGCGGCCGCCACGTCTGGGCGGTGCGGGCAGCGCTGCAGCCGATCGCTGATCCCGACATACCAGCCGAGGC
GGTGGACCTTCGTGGGCTCGGCCGAATCATGGACGACACCAGCAGCCAACTGGTGTCGTCGGCATCGGCGCTGTTGAACT
GGCATGACAACGCACGATTCAGCGCCCTAGACGGCGCGCCGACGAAACCGGCCAGGGCCGGCTGGTCACGGGTCAACCCG
ATCACCGGTCATGAGGAGTTCCCCCGTATCGACCCGGCGGTGATCTGCCTGGTTCACGACGGCGCTGATCGTGCCGTGTT
GGCTCGCCAGGCGGCGTGGCCGGAACGGATGTTCTCGCTGTTGGCTGGCTTTGTCGAGGCCGGAGAGTCGTTCGAAGTCT
GCGTCGCCCGGGAGATCCGCGAGGAAATCGGCCTGACCGTTCGCGATGTGCGCTATCTGGGCAGCCAGCCGTGGCCGTTC
CCGCGGTCGTTAATGGTTGGCTTTCATGCCTTGGGTGACCCGGATGAGGAGTTCTCGTTCAGCGACGGCGAAATCGCCGA
AGCCGCGTGGTTCACCCGCGATGAGGTGCGCGCAGCGCTTGCCGCCGGCGATTGGTCCAGTGCGTCGGAGTCGAAACTGC
TACTGCCCGGGTCGATCTCGATCGCCCGCGTGATCATCGAATCGTGGGCAGCGTGCGAATGA

Upstream 100 bases:

>100_bases
GCCAGCGACCGGCTGCTCTATATTCGCCAGGTGGGGCGCTAGTGGCGATCGCAAGCGCGGCGGAGCCGGGCGCGGCGGGT
CGCCACCAGGTGGGGCGCCA

Downstream 100 bases:

>100_bases
AAGTCCACGTCGTTAACCCGCGATCTTTACCAGCTTCGCTTTGACCTCGTCCGCGCTCGGGTTAGTCAGCGTCGACCCGT
CGGCGAACTTCACCGTGGGA

Product: NADH pyrophosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLG
RVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNP
ITGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPF
PRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSISIARVIIESWAACE

Sequences:

>Translated_313_residues
MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLG
RVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNP
ITGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPF
PRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSISIARVIIESWAACE
>Mature_312_residues
TNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGR
VEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPI
TGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPFP
RSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSISIARVIIESWAACE

Specific function: Unknown

COG id: COG2816

COG function: function code L; NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Homo sapiens, GI50593112, Length=227, Percent_Identity=37.0044052863436, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI13899267, Length=265, Percent_Identity=31.6981132075472, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI48994995, Length=154, Percent_Identity=32.4675324675325, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI212645999, Length=119, Percent_Identity=38.655462184874, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71986510, Length=119, Percent_Identity=38.655462184874, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321371, Length=216, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUDC_MYCBO (Q7TX14)

Other databases:

- EMBL:   BX248345
- RefSeq:   NP_856869.1
- ProteinModelPortal:   Q7TX14
- EnsemblBacteria:   EBMYCT00000015000
- GeneID:   1094077
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3224c
- GeneTree:   EBGT00050000017381
- HOGENOM:   HBG736436
- OMA:   LNWHDSA
- ProtClustDB:   PRK00241
- BioCyc:   MBOV233413:MB3224C-MONOMER
- BRENDA:   3.6.1.22
- HAMAP:   MF_00297
- InterPro:   IPR015375
- InterPro:   IPR022925
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR015376
- Gene3D:   G3DSA:3.90.79.10

Pfam domain/function: PF00293 NUDIX; PF09296 NUDIX-like; PF09297 zf-NADH-PPase; SSF55811 NUDIX_hydrolase

EC number: =3.6.1.22

Molecular weight: Translated: 33796; Mature: 33664

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRV
CCCCCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCE
LLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDT
EEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHCCH
SSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITGHEEFPRIDPAVICLVHD
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPF
CCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHCCCCCCC
PRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSIS
CHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHH
IARVIIESWAACE
HHHHHHHHHHCCC
>Mature Secondary Structure 
TNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRV
CCCCCCCEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCE
LLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDT
EEEEEEECCCCCCCCEEEEEECCCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHCCH
SSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITGHEEFPRIDPAVICLVHD
HHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
GADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPF
CCCHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHCCCCCCC
PRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSIS
CHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCHH
IARVIIESWAACE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972