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The map label for this gene is hisN [H]

Identifier: 121639020

GI number: 121639020

Start: 3456440

End: 3457222

Strand: Direct

Name: hisN [H]

Synonym: BCG_3160

Alternate gene names: 121639020

Gene position: 3456440-3457222 (Clockwise)

Preceding gene: 121639019

Following gene: 121639021

Centisome position: 79.01

GC content: 67.05

Gene sequence:

>783_bases
GTGAGCCACGACGATCTAATGCTTGCGCTGGCTCTGGCCGACCGTGCGGACGAATTGACGCGGGTCCGGTTCGGGGCGCT
CGATCTGCGCATCGACACCAAACCGGATTTGACGCCGGTGACCGACGCCGATCGGGCGGTCGAATCCGACGTGCGCCAGA
CGCTGGGCCGCGACCGGCCCGGCGACGGCGTCTTGGGCGAGGAGTTCGGCGGATCAACGACCTTCACCGGACGGCAGTGG
ATCGTAGACCCGATCGACGGCACCAAAAACTTTGTGCGCGGGGTGCCGGTGTGGGCCAGTTTGATCGCGCTGCTTGAAGA
TGGCGTCCCGTCGGTCGGTGTGGTGAGTGCGCCGGCGCTGCAACGGCGGTGGTGGGCGGCACGCGGCCGGGGCGCGTTCG
CATCCGTCGATGGTGCGCGTCCACACCGGCTGTCGGTTTCCTCTGTGGCAGAGCTGCATTCGGCGAGCTTGTCGTTTTCC
AGTCTGTCCGGGTGGGCGCGGCTGGGTCTACGTGAACGCTTCATCGGGTTGACCGATACCGTGTGGCGCGTGCGTGCTTA
CGGCGACTTTCTGTCTTACTGCCTGGTGGCCGAGGGCGCCGTCGATATTGCCGCCGAACCGCAAGTGTCGGTATGGGATC
TGGCGGCACTGGACATCGTGGTGCGTGAGGCGGGCGGGCGGCTCACCAGCCTGGACGGCGTCGCCGGCCCACACGGGGGC
AGCGCCGTTGCAACCAACGGTCTGTTGCACGACGAGGTGCTGACACGGCTCAACGCCGGGTAA

Upstream 100 bases:

>100_bases
CTGCTGGCATGAGCCGTTATTACGCCGAGCGTGAACTCAGTGCAAGAACGCACGCGAAAAATCGCACTGGGTACACGCTC
GGCGAAAGGATGGTGCACCA

Downstream 100 bases:

>100_bases
CCTGGCGCTCGAGAGCGCCATGAGCGACCCGTTCACCATCGCAACCAAACACTGGCACCGACTGCACGACAGCCGGATCC
AGTGCGATGTATGTCCACGC

Product: putative monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQW
IVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFS
SLSGWARLGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGG
SAVATNGLLHDEVLTRLNAG

Sequences:

>Translated_260_residues
MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQW
IVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFS
SLSGWARLGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGG
SAVATNGLLHDEVLTRLNAG
>Mature_259_residues
SHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWI
VDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSS
LSGWARLGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGGS
AVATNGLLHDEVLTRLNAG

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=240, Percent_Identity=30, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5031789, Length=240, Percent_Identity=29.5833333333333, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI221625487, Length=240, Percent_Identity=29.5833333333333, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788882, Length=202, Percent_Identity=31.1881188118812, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790659, Length=201, Percent_Identity=29.3532338308458, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193202570, Length=240, Percent_Identity=31.25, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI193202572, Length=237, Percent_Identity=29.957805907173, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320493, Length=197, Percent_Identity=31.9796954314721, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357329, Length=200, Percent_Identity=34, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24664918, Length=211, Percent_Identity=29.3838862559242, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357957, Length=246, Percent_Identity=28.0487804878049, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664926, Length=203, Percent_Identity=26.6009852216749, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664922, Length=240, Percent_Identity=26.25, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27709; Mature: 27578

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRP
CCCCHHEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPAL
CCCCCCCCCCCCCEECCCEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCEECCHHH
QRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARLGLRERFIGLTDT
HHHHHHHCCCCCEEECCCCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHH
VWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGG
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCC
SAVATNGLLHDEVLTRLNAG
CHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRP
CCCHHEEHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCC
GDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPAL
CCCCCCCCCCCCCEECCCEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCCCEECCHHH
QRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARLGLRERFIGLTDT
HHHHHHHCCCCCEEECCCCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHH
VWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGG
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCC
SAVATNGLLHDEVLTRLNAG
CHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]