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The map label for this gene is lepB [H]

Identifier: 121638784

GI number: 121638784

Start: 3166902

End: 3167786

Strand: Reverse

Name: lepB [H]

Synonym: BCG_2924c

Alternate gene names: 121638784

Gene position: 3167786-3166902 (Counterclockwise)

Preceding gene: 121638785

Following gene: 121638783

Centisome position: 72.41

GC content: 64.97

Gene sequence:

>885_bases
GTGACCGAAACCACGGACTCCCCATCGGAGCGCCAGCCGGGTCCGGCAGAGCCGGAGCTCTCCTCCCGGGACCCGGACAT
TGCCGGCCAGGTCTTCGACGCAGCCCCGTTCGACGCAGCCCCGGATGCGGACTCCGAAGGCGACTCCAAGGCGGCCAAAA
CGGACGAGCCGCGGCCCGCGAAGCGATCAACGCTGCGGGAGTTCGCGGTGCTGGCGGTGATTGCTGTGGTGCTCTACTAC
GTCATGCTGACGTTTGTCGCGCGCCCTTATCTGATTCCGTCGGAATCGATGGAACCCACGTTGCACGGGTGTTCGACGTG
CGTCGGCGACCGCATCATGGTGGACAAACTCAGCTACCGCTTCGGCTCACCGCAACCTGGCGACGTCATCGTCTTCAGGG
GACCGCCGTCGTGGAACGTTGGTTACAAGTCGATCCGTTCGCACAACGTCGCCGTGCGCTGGGTGCAGAACGCGTTGTCG
TTCATCGGTTTCGTGCCTCCCGACGAGAACGACCTGGTCAAGCGTGTCATCGCGGTCGGCGGACAGACGGTTCAATGCCG
GTCCGACACCGGCCTGACGGTCAACGGCAGGCCACTGAAGGAGCCATACCTGGATCCGGCCACCATGATGGCCGACCCGT
CGATATACCCGTGCCTGGGCAGCGAGTTCGGGCCGGTCACCGTCCCGCCCGGGCGTGTCTGGGTGATGGGCGACAACCGC
ACCCATTCGGCGGATTCCCGCGCTCACTGCCCGTTGCTATGTACTAACGATCCGCTACCGGGGACCGTGCCGGTGGCCAA
CGTCATCGGTAAGGCCAGGTTGATCGTGTGGCCGCCGTCGCGTTGGGGTGTTGTGCGTTCGGTGAATCCCCAGCAAGGTC
GGTAG

Upstream 100 bases:

>100_bases
CGAACTGCGCGGAAAGAAGGCCAAGATCAAGGAGAAGCGCTGACCGGGAACGTCTCGGCGATGTTCGAAAGCCGCCACCT
GCGCTGGCTACGCTGATCTC

Downstream 100 bases:

>100_bases
CCATGGCTGGAATATGACCAAGACCTGGCCACCGCGGACGGTGATCCGTAAATCTGGGGGTTTGCGGGGAATGCGCACCC
TGGAGTCCGCGCTGCATCGT

Product: putative signal peptidase I lepB

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYY
VMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALS
FIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNR
THSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR

Sequences:

>Translated_294_residues
MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYY
VMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALS
FIGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNR
THSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR
>Mature_293_residues
TETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPAKRSTLREFAVLAVIAVVLYYV
MLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYRFGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSF
IGFVPPDENDLVKRVIAVGGQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNRT
HSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 31880; Mature: 31748

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
KRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHH
FGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVG
CCCCCCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNR
CCEEEECCCCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEECCCCEEEEEECCC
THSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR
CCCCCCCCCCCEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TETTDSPSERQPGPAEPELSSRDPDIAGQVFDAAPFDAAPDADSEGDSKAAKTDEPRPA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCH
KRSTLREFAVLAVIAVVLYYVMLTFVARPYLIPSESMEPTLHGCSTCVGDRIMVDKLSYR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEHHHHHH
FGSPQPGDVIVFRGPPSWNVGYKSIRSHNVAVRWVQNALSFIGFVPPDENDLVKRVIAVG
CCCCCCCCEEEECCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GQTVQCRSDTGLTVNGRPLKEPYLDPATMMADPSIYPCLGSEFGPVTVPPGRVWVMGDNR
CCEEEECCCCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEECCCCEEEEEECCC
THSADSRAHCPLLCTNDPLPGTVPVANVIGKARLIVWPPSRWGVVRSVNPQQGR
CCCCCCCCCCCEEECCCCCCCCCHHHHHCCCEEEEEECCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]