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The map label for this gene is ruvA

Identifier: 121638478

GI number: 121638478

Start: 2888686

End: 2889276

Strand: Reverse

Name: ruvA

Synonym: BCG_2616c

Alternate gene names: 121638478

Gene position: 2889276-2888686 (Counterclockwise)

Preceding gene: 121638479

Following gene: 121638477

Centisome position: 66.05

GC content: 69.04

Gene sequence:

>591_bases
ATGATCGCCTCGGTCCGCGGTGAGGTGCTCGAGGTGGCACTTGACCATGTGGTGATCGAGGCCGCCGGTGTGGGCTACCG
AGTGAACGCGACACCGGCGACGCTGGCGACGTTGCGGCAAGGCACCGAGGCCCGGCTGATCACCGCGATGATTGTGCGCG
AGGACTCGATGACGCTGTACGGGTTTCCCGACGGGGAAACCCGCGACCTATTCCTGACGCTGCTGTCGGTCTCCGGCGTT
GGGCCCCGGCTGGCGATGGCGGCACTGGCCGTGCACGACGCTCCGGCGCTACGGCAGGTGCTGGCCGACGGCAACGTCGC
CGCCCTGACCCGGGTGCCTGGGATCGGCAAGCGGGGCGCCGAACGCATGGTGTTGGAACTACGCGACAAGGTTGGGGTGG
CAGCCACCGGCGGCGCACTCTCGACCAACGGCCACGCGGTGCGCAGTCCCGTGGTCGAGGCTCTGGTCGGCCTGGGCTTT
GCGGCCAAACAGGCCGAGGAGGCCACCGATACGGTGCTGGCCGCCAACCATGACGCGACGACATCCAGCGCGCTGCGGTC
TGCCTTGTCGTTGCTGGGGAAGGCCCGATGA

Upstream 100 bases:

>100_bases
GGGCGCCGACGATCGCCCGGATGGCTGAGGCCACGTCGAGGGCGGAAGCACGAGCAGCGCAGCAGCGTCATGCGTACCTA
GCCAAGCTGAAGGCCGCCCG

Downstream 100 bases:

>100_bases
CCGAGCGGTCCGACCGCGACGTTTCGCCCGCACTCACCGTCGGAGAGGGCGACATCGACGTCAGCCTGCGGCCGCGCTCG
TTACGCGAATTCATCGGCCA

Product: Holliday junction DNA helicase RuvA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGV
GPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGF
AAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR

Sequences:

>Translated_196_residues
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGV
GPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGF
AAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR
>Mature_196_residues
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLYGFPDGETRDLFLTLLSVSGV
GPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGAERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGF
AAKQAEEATDTVLAANHDATTSSALRSALSLLGKAR

Specific function: The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday

COG id: COG0632

COG function: function code L; Holliday junction resolvasome, DNA-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvA family

Homologues:

Organism=Escherichia coli, GI1788168, Length=203, Percent_Identity=34.4827586206897, Blast_Score=103, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVA_MYCBO (P66745)

Other databases:

- EMBL:   BX248343
- RefSeq:   NP_856270.1
- ProteinModelPortal:   P66745
- SMR:   P66745
- EnsemblBacteria:   EBMYCT00000015283
- GeneID:   1092008
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2624c
- GeneTree:   EBGT00050000017612
- HOGENOM:   HBG635309
- OMA:   LSIETYV
- ProtClustDB:   PRK00116
- BioCyc:   MBOV233413:MB2624C-MONOMER
- HAMAP:   MF_00031
- InterPro:   IPR011114
- InterPro:   IPR013849
- InterPro:   IPR003583
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR000085
- InterPro:   IPR010994
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00278
- TIGRFAMs:   TIGR00084

Pfam domain/function: PF07499 RuvA_C; PF01330 RuvA_N; SSF50249 Nucleic_acid_OB; SSF47781 RuvA_2_like; SSF46929 RuvA_C-like

EC number: =3.6.4.12

Molecular weight: Translated: 20190; Mature: 20190

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLY
CCCCHHHHHHHHHHHHHHHEECCCCEEECCCHHHHHHHHCCCHHHHHHHEEEECCCEEEE
GFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGA
ECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCCCH
ERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDAT
HHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCC
TSSALRSALSLLGKAR
HHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIASVRGEVLEVALDHVVIEAAGVGYRVNATPATLATLRQGTEARLITAMIVREDSMTLY
CCCCHHHHHHHHHHHHHHHEECCCCEEECCCHHHHHHHHCCCHHHHHHHEEEECCCEEEE
GFPDGETRDLFLTLLSVSGVGPRLAMAALAVHDAPALRQVLADGNVAALTRVPGIGKRGA
ECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCCCCCH
ERMVLELRDKVGVAATGGALSTNGHAVRSPVVEALVGLGFAAKQAEEATDTVLAANHDAT
HHHHHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHEEECCCCCC
TSSALRSALSLLGKAR
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972