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The map label for this gene is panE [C]

Identifier: 121638458

GI number: 121638458

Start: 2862490

End: 2863230

Strand: Direct

Name: panE [C]

Synonym: BCG_2596

Alternate gene names: 121638458

Gene position: 2862490-2863230 (Clockwise)

Preceding gene: 121638455

Following gene: 121638459

Centisome position: 65.44

GC content: 70.45

Gene sequence:

>741_bases
GTGGTGCCCGGTCCGGTGCACACCAGTCCTCGGGAGGTTGCCGGCCCGGTCGATGTGCTGATCCTGGCGGTCAAGGCCAC
TCAGAACGACGCCGCACGTCCCTGGCTGACCCGCCTGTGCGACGAGCGCACCGTGGTGGCCGTGCTGCAAAACGGTGTCG
AACAGGTCGAGCAGGTCCAGCCGCATTGTCCGTCCTCGGCCGTGGTTCCCGCGATCGTGTGGTGTTCGGCCGAGACCCAG
CCGCAAGGGTGGGTGCGCTTGCGCGGTGAAGCCGCACTGGTCGTTCCCACCGGGCCCGCGGCCGAGCAGTTCGCCGGGCT
GCTGCGCGGTGCCGGCGCCACGGTGGACTGCGACCCCGACTTCACCACGGCGGCCTGGCGCAAACTACTGGTCAACGCGC
TGGCGGGATTTATGGTGCTGTCCGGACGGCGGTCGGCAATGTTCCGCCGCGACGACGTCGCGGCATTGTCGCGCCGCTAT
GTCGCCGAATGCCTGGCGGTGGCGCGCGCTGAGGGTGCCCGACTCGATGACGACGTCGTCGACGAAGTGGTCCGCCTCGT
CCGGTCGGCCCCGCAGGACATGGGCACCTCGATGCTGGCCGACCGGGCAGCCCACCGGCCACTGGAATGGGATTTGCGCA
ATGGGGTGATCGTCCGCAAGGCCCGCGCCCACGGCCTGGCCACCCCGATCAGCGACGTGCTGGTGCCGCTGCTGGCGGCT
GCCAGCGACGGTCCCGGATAG

Upstream 100 bases:

>100_bases
GGTCGCCGCGCTGTTGCACAAGGCCGGGTATTCGCCGCTGTTGTGCGGCCACACTCCGCGCGCCGGGATCGAGCTCCGGC
GAGACGGCGCAGACCCCATC

Downstream 100 bases:

>100_bases
CAATGTAGCTAATGTCTAGATCATGTACCCCTGCGAGCGGGTAGGCCTGAGCTTCACCGAGACCGCGCCTTACCTCTTCC
GCAACACCGTCGACCTGGCC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQ
PQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRY
VAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
ASDGPG

Sequences:

>Translated_246_residues
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQ
PQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRY
VAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
ASDGPG
>Mature_246_residues
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQPHCPSSAVVPAIVWCSAETQ
PQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPDFTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRY
VAECLAVARAEGARLDDDVVDEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
ASDGPG

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 26216; Mature: 26216

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQ
CCCCCCCCCCHHHCCCHHHHEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHC
PHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPD
CCCCCCCHHHHHEEECCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHCCCCEEECCCC
FTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASDGPG
CCCCCC
>Mature Secondary Structure
MVPGPVHTSPREVAGPVDVLILAVKATQNDAARPWLTRLCDERTVVAVLQNGVEQVEQVQ
CCCCCCCCCCHHHCCCHHHHEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHC
PHCPSSAVVPAIVWCSAETQPQGWVRLRGEAALVVPTGPAAEQFAGLLRGAGATVDCDPD
CCCCCCCHHHHHEEECCCCCCCCEEEECCCEEEEEECCCCHHHHHHHHHCCCCEEECCCC
FTTAAWRKLLVNALAGFMVLSGRRSAMFRRDDVAALSRRYVAECLAVARAEGARLDDDVV
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
DEVVRLVRSAPQDMGTSMLADRAAHRPLEWDLRNGVIVRKARAHGLATPISDVLVPLLAA
HHHHHHHHHCCHHHHHHHHHHHHHCCCCCEECCCCEEEEEHHHCCCCCCHHHHHHHHHHH
ASDGPG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]