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The map label for this gene is cobC [C]

Identifier: 121638300

GI number: 121638300

Start: 2682317

End: 2682988

Strand: Reverse

Name: cobC [C]

Synonym: BCG_2435c

Alternate gene names: 121638300

Gene position: 2682988-2682317 (Counterclockwise)

Preceding gene: 121638301

Following gene: 121638299

Centisome position: 61.33

GC content: 66.82

Gene sequence:

>672_bases
ATGAGAGCGCGGCGACTGGTGATGCTGCGGCATGGACAAACGGACTACAACGTCGGTAGCCGGATGCAGGGCCAGCTGGA
CACTGAGTTGAGCGAACTTGGCCGCACCCAAGCGGTCGCGGCCGCCGAGGTGCTGGGCAAGCGGCAGCCGCTACTGATCG
TATCGTCGGACCTGCGCCGCGCATATGACACGGCGGTCAAGCTGGGCGAGCGCACCGGCCTTGTGGTCCGGGTCGACACC
CGATTGCGGGAAACTCACCTTGGCGATTGGCAGGGCTTAACCCACGCTCAGATCGACGCTGATGCCCCGGGCGCCCGGTT
GGCCTGGCGCGAGGATGCGACCTGGGCGCCGCACGGCGGGGAAAGCAGGGTTGACGTGGCTGCCCGAAGTCGGCCGTTGG
TTGCCGAGTTGGTTGCCAGCGAACCGGAATGGGGTGGCGCTGACGAGCCGGATCGCCCGGTGGTGCTGGTAGCCCATGGG
GGTCTGATCGCCGCGTTGTCGGCGGCGCTGCTGAAGTTGCCGGTGGCCAACTGGCCGGCTTTGGGCGGCATGGGCAATGC
CAGTTGGACTCAGCTGAGTGGCCATTGGGCCCCGGGCTCCGACTTCGAGAGCATCCGGTGGCGCCTTGATGTGTGGAATG
CTTCGGCGCAGGTCTCCAGCGATGTCCTCTAG

Upstream 100 bases:

>100_bases
AGCATCAGGACGACCGCAATTTCTACGCCCTGGACCGGTTGTGGGGTGACTGCCCGGTGGTGCCGGTTGATTTATCGGCG
AACTCAGCGGGTGCGCCGCA

Downstream 100 bases:

>100_bases
GCGCGGGCGCAGGCCCGCATTGTTGGTCTTCGCTGACTCGCTGGCCTACTACGGGCCCACCGGCGGCCTGCCTGCCGATG
ACCCCCGTATCTGGCCCAAT

Product: putative phosphoglycerate mutase

Products: 3-phospho-D-glycerate

Alternate protein names: Phosphoglyceromutase

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDT
RLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHG
GLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL

Sequences:

>Translated_223_residues
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDT
RLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHG
GLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
>Mature_223_residues
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRRAYDTAVKLGERTGLVVRVDT
RLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGGESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHG
GLIAALSAALLKLPVANWPALGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y2419_MYCTU (P71724)

Other databases:

- EMBL:   BX842579
- EMBL:   AE000516
- PIR:   F70685
- RefSeq:   NP_216935.1
- RefSeq:   NP_336975.1
- HSSP:   Q9ALU0
- ProteinModelPortal:   P71724
- SMR:   P71724
- EnsemblBacteria:   EBMYCT00000000186
- EnsemblBacteria:   EBMYCT00000069149
- GeneID:   885727
- GeneID:   925843
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT2492
- KEGG:   mtu:Rv2419c
- TIGR:   MT2492
- TubercuList:   Rv2419c
- GeneTree:   EBGT00050000015083
- HOGENOM:   HBG658938
- OMA:   HGGESRI
- ProtClustDB:   CLSK791839
- InterPro:   IPR013078
- InterPro:   IPR001345
- SMART:   SM00855

Pfam domain/function: PF00300 PGAM

EC number: 5.4.2.1

Molecular weight: Translated: 24175; Mature: 24175

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 11-11 ACT_SITE 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRR
CCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHH
AYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGG
HHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCC
ESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPA
CCCEEHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
LGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
CCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCHHCCCC
>Mature Secondary Structure
MRARRLVMLRHGQTDYNVGSRMQGQLDTELSELGRTQAVAAAEVLGKRQPLLIVSSDLRR
CCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEECHHHHH
AYDTAVKLGERTGLVVRVDTRLRETHLGDWQGLTHAQIDADAPGARLAWREDATWAPHGG
HHHHHHHHHCCCCEEEEECCHHHHHCCCCCCCCCEEEECCCCCCCEEEECCCCCCCCCCC
ESRVDVAARSRPLVAELVASEPEWGGADEPDRPVVLVAHGGLIAALSAALLKLPVANWPA
CCCEEHHHCCCCHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCC
LGGMGNASWTQLSGHWAPGSDFESIRWRLDVWNASAQVSSDVL
CCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-phospho-D-glycerate

Specific reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036