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The map label for this gene is mbtB [H]

Identifier: 121638262

GI number: 121638262

Start: 2636615

End: 2640859

Strand: Reverse

Name: mbtB [H]

Synonym: BCG_2397c

Alternate gene names: 121638262

Gene position: 2640859-2636615 (Counterclockwise)

Preceding gene: 121638265

Following gene: 121638261

Centisome position: 60.37

GC content: 68.86

Gene sequence:

>4245_bases
GTGGTGCATGCTACGGCGTGCTCGGAGATCATTCGCGCCGAGGTCGCAGAGTTGCTCGGTGTCCGCGCCGATGCTCTGCA
CCCCGGCGCCAACCTCGTTGGTCAGGGCCTGGACTCGATCCGGATGATGTCGCTGGTGGGGCGCTGGCGCCGGAAGGGCA
TCGCCGTCGACTTCGCCACACTGGCCGCCACACCCACAATCGAGGCCTGGTCCCAACTGGTGTCCGCCGGCACCGGCGTC
GCGCCCACGGCAGTTGCCGCACCAGGGGATGCCGGGTTATCCCAGGAAGGCGAGCCTTTCCCGCTGGCGCCGATGCAGCA
CGCGATGTGGGTCGGCCGCCACGACCACCAACAGCTCGGCGGGGTAGCTGGGCACCTCTACGTCGAGTTCGATGGTGCCC
GGGTCGATCCGGACAGGCTCCGCGCGGCGGCCACCCGGTTGGCGCTGCGGCACCCGATGCTGCGGGTGCAGTTCTTGCCC
GACGGCACCCAGCGCATCCCGCCGGCGGCGGGATCTCGCGACTTTCCCATCAGTGTTGCCGACCTGCGTCACGTGGCCCC
GGATGTCGTCGATCAGCGGTTGGCGGGGATCCGCGACGCCAAATCGCACCAGCAGCTCGACGGTGCGGTATTCGAACTTG
CGTTGACGTTATTACCGGGGGAGCGCACCCGCCTACATGTCGACCTGGACATGCAGGCCGCTGACGCGATGAGCTACCGC
ATCTTGCTGGCCGACCTGGCGGCCCTCTATGACGGCCGTGAACCGCCGGCACTGGGCTACACCTACCAGGAATACCGGCA
GGCTATCGAGGCGGAGGAGACGCTGCCCCAACCGGTTCGCGACGCCGACCGGGACTGGTGGGCGCAGCGCATCCCGCAGC
TGCCGGATCCGCCCGCGCTGCCTACCCGGGCCGGCGGCGAACGCGACCGGCGCCGCAGCACCCGGCGCTGGCACTGGCTA
GACCCGCAGACCCGCGACGCGTTGTTCGCCCGAGCCCGGGCCCGCGGCATCACCCCGGCGATGACGCTGGCCGCGGCCTT
TGCCAACGTGCTGGCGCGTTGGTCAGCGTCGTCGCGGTTCCTGCTGAACCTGCCGTTGTTCAGTCGCCAGGCCCTGCATC
CAGACGTCGACCTGCTGGTCGGTGACTTCACCTCCTCGCTGTTGCTCGACGTCGATCTGACCGGTGCGCGCACGGCGGCG
GCGCGGGCGCAGGCGGTGCAGGAAGCCCTGCGCAGCGCCGCAGGCCACAGTGCATACCCCGGGCTGTCTGTGCTGCGTGA
CCTCAGCCGCCACCGTGGCACCCAGGTGCTGGCACCGGTGGTATTCACCAGCGCGCTGGGGCTCGGCGACCTTTTCTGCC
CGGACGTCACCGAGCAATTCGGCACACCCGGATGGATCATTTCGCAGGGGCCCCAGGTGCTGCTCGACGCCCAGGTCACC
GAGTTCGACGGCGGTGTGCTGGTGAACTGGGATGTCCGCGAGGGGGTCTTTGCACCCGGCGTCATCGACGCCATGTTCAC
CCACCAGGTCGACGAATTGCTCCGGTTGGCCGCCGGGGACGACGCCTGGGATGCGCCGAGCCCGTCCGCGCTACCCGCCG
CGCAACGCGCGGTGCGCGCGGCGCTGAACGGTCGCACCGCCGCCCCCAGCACCGAGGCGCTGCACGACGGGTTTTTCCGC
CAGGCCCAACAGCAGCCCGACGCGCCGGCGGTGTTCGCCAGTTCCGGCGACTTGAGCTACGCCCAACTGCGCGACCAGGC
ATCGGCGGTGGCCGCGGCGCTGCGTGCTGCGGGCCTACGAGTCGGCGACACCGTCGCGGTGCTGGGTCCGAAAACGGGCG
AACAAGTGGCGGCTGTGCTGGGGATTTTGGCCGCCGGCGGGGTCTATCTGCCGATCGGCGTCGACCAGCCCCGCGACCGC
GCGGAGCGCATCCTGGCGACCGGTTCGGTCAACTTAGCGCTCGTTTGCGGCCCGCCATGCCAAGTGCGGGTGCCGGTCCC
GACGCTGTTGCTGGCTGACGTGCTTGCCGCCGCGCCGGCAGAATTCGTGCCCGGGCCTAGCGATCCCACCGCGCTCGCCT
ATGTGTTGTTCACCTCGGGCTCAACCGGGGAACCCAAGGGTGTCGAGGTGGCGCACGACGCCGCGATGAACACCGTGGAG
ACCTTCATCCGGCACTTCGAGCTAGGCGCCGCAGATCGCTGGCTTGCCCTGGCGACGCTGGAGTGCGACATGTCGGTGCT
GGACATCTTCGCCGCCCTGCGCTCCGGCGGAGCGATCGTGGTGGTCGACGAAGCGCAGCGCCGCGATCCCGACGCCTGGG
CCCGGCTTATCGACACTTACGAGGTCACGGCGTTGAATTTCATGCCGGGCTGGTTGGACATGCTGCTCGAAGTCGGCGGG
GGCCGGCTGTCGTCGCTGCGAGCGGTGGCCGTCGGCGGCGACTGGGTGCGTCCCGACCTGGCCCGCCGCCTGCAGGTGCA
AGCGCCGAGCGCACGGTTCGCGGGGTTGGGTGGAGCCACCGAAACCGCGGTCCACGCAACCATTTTCGAGGTCCAGGACG
CGGCCAATCTGCCACCGGACTGGGCCTCGGTGCCATACGGCGTCCCGTTTCCCAACAACGCCTGCCGGGTAGTGGCCGAC
AGCGGCGACGACTGCCCCGATTGGGTGGCCGGTGAGTTGTGGGTGTCCGGTCGCGGAATCGCCCGGGGTTACCGTGGCCG
TCCCGAGCTGACCGCGGAGCGCTTCGTCGAGCATGACGGCCGCACCTGGTATCGCACCGGTGATCTGGCCCGCTACTGGC
ACGACGGCACCCTGGAGTTCGTCGGCCGTGCCGATCACCGCGTCAAGATCAGCGGGTACCGCGTCGAACTCGGCGAGATC
GAAGCCGCGCTGCAGCGCTTGCCCGGTGTGCACGCGGCGGCGGCCACCGTGCTTCCTGGCGGGTCCGATGTGCTGGCCGC
GGCGGTCTGCGTCGACGATGCCGGCGTGACCGCGGAGTCGATTCGACAGCAGCTCGCCGATCTGGTGCCCGCGCACATGA
TTCCGCGCCACGTCACGCTGCTAGACCGCATCCCCTTTACCGACAGCGGCAAGATCGACCGCGCGGAGGTTGGCGCCCTG
CTTGCCGCCGAGGTCGAGCGGTCTGGCGACAGATCGGCACCCTATGCGGCGCCGCGAACGGTGCTTCAGCGGGCACTGCG
CCGCATCGTCGCGGACATCCTGGGCCGTGCCAACGATGCCGTGGGCGTGCACGACGACTTCTTTGCCCTGGGCGGCGATT
CCGTGCTTGCGACCCAGGTCGTCGCCGGTATCCGGCGGTGGCTGGATTCGCCGAGCCTGATGGTCGCCGACATGTTTGCC
GCCAGGACCATTGCCGCGTTGGCCCAGTTGCTCACCGGTCGGGAAGCCAACGCCGACCGACTCGAACTGGTCGCCGAGGT
GTACTTAGAAATCGCGAATATGACAAGTGCCGACGTGATGGCGGCGCTCGATCCGATCGAGCAGCCCGCACAGCCAGCCT
TCAAACCGTGGGTGAAGCGGTTCACCGGTACTGACAAGCCCGGCGCGGTGCTGGTGTTTCCACACGCCGGCGGCGCTGCC
GCGGCTTACCGGTGGTTGGCAAAATCGTTAGTGGCCAACGACGTTGACACGTTCGTGGTGCAGTACCCGCAGCGGGCTGA
CCGGCGCAGCCACCCGGCGGCAGACAGCATCGAGGCGCTGGCGCTCGAGCTGTTCGAGGCGGGCGACTGGCACCTGCCGG
CTCCGCTGACGCTGTTCGGCCATTGCATGGGTGCGATAGTGGCCTTCGAGTTCGCTCGCCTCGCCGAGCGCAATGGCGTG
CCGGTACGTGCACTGTGGGCTTCCTCCGGTCAGGCTCCGTCGACGGTGGCCGCGTCCGGACCGTTGCCGACCGCCGACCG
TGACGTCCTGGCCGACATGGTGGATCTTGGCGGCACCGATCCCGTGCTGCTCGAGGACGAGGAATTCGTTGAACTGCTGG
TGCCGGCGGTCAAGGCCGACTATCGGGCCCTCAGCGGCTATTCATGTCCACCCGACGTGCGCATCCGCGCCAACATCCAC
GCGGTCGGCGGCAACCGCGACCACCGCATCAGCCGGGAGATGTTGACCAGTTGGGAGACTCACACCTCCGGTCGCTTCAC
GCTGTCGCACTTTGATGGTGGTCACTTCTATCTCAACGATCACCTCGACGCCGTGGCCCGGATGGTGAGTGCCGATGTCC
GATAA

Upstream 100 bases:

>100_bases
ATGTGGGCTCCTTAACAGGGGGGCTGGTAGCGCAGGTGCGTGGTTCGAAGATAGGGTAACCACTAAAATTAGGGCAGCCT
GTGCTAACAGGGGAGGGTTT

Downstream 100 bases:

>100_bases
CGACCCGGTCGTCATCGTCGGGCTGGCCATCGAGGCACCCGGTGGTGTCGAAACCGCCGACGACTACTGGACACTGCTCT
CCGAACAGCGCGAGGGACTC

Product: phenyloxazoline synthase mbtB

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Mycobactin synthetase protein B [H]

Number of amino acids: Translated: 1414; Mature: 1414

Protein sequence:

>1414_residues
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGV
APTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLP
DGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
ILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWL
DPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAA
ARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFR
QAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDR
AERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGG
GRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVAD
SGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGAL
LAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFA
ARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLPAPLTLFGHCMGAIVAFEFARLAERNGV
PVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIH
AVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR

Sequences:

>Translated_1414_residues
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGV
APTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLP
DGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
ILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWL
DPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAA
ARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFR
QAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDR
AERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGG
GRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVAD
SGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGAL
LAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFA
ARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLPAPLTLFGHCMGAIVAFEFARLAERNGV
PVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIH
AVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR
>Mature_1414_residues
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFATLAATPTIEAWSQLVSAGTGV
APTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLGGVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLP
DGTQRIPPAAGSRDFPISVADLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
ILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPALPTRAGGERDRRRSTRRWHWL
DPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRFLLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAA
ARAQAVQEALRSAAGHSAYPGLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRAALNGRTAAPSTEALHDGFFR
QAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLRVGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDR
AERILATGSVNLALVCGPPCQVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTYEVTALNFMPGWLDMLLEVGG
GRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGATETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVAD
SGDDCPDWVAGELWVSGRGIARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTLLDRIPFTDSGKIDRAEVGAL
LAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDAVGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFA
ARTIAALAQLLTGREANADRLELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLPAPLTLFGHCMGAIVAFEFARLAERNGV
PVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTDPVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIH
AVGGNRDHRISREMLTSWETHTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR

Specific function: Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threonine and cyclizes this precursor to the hydroxyphenyloxazoline ring system present in this class of siderophores [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=431, Percent_Identity=27.1461716937355, Blast_Score=117, Evalue=1e-25,
Organism=Homo sapiens, GI38505220, Length=577, Percent_Identity=25.3032928942808, Blast_Score=97, Evalue=1e-19,
Organism=Homo sapiens, GI157311624, Length=528, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI157311622, Length=528, Percent_Identity=22.7272727272727, Blast_Score=86, Evalue=2e-16,
Organism=Homo sapiens, GI58082049, Length=528, Percent_Identity=22.7272727272727, Blast_Score=81, Evalue=6e-15,
Organism=Homo sapiens, GI122937307, Length=516, Percent_Identity=23.2558139534884, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1786801, Length=787, Percent_Identity=28.843710292249, Blast_Score=233, Evalue=6e-62,
Organism=Escherichia coli, GI1788107, Length=543, Percent_Identity=24.6777163904236, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI145693145, Length=525, Percent_Identity=25.9047619047619, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=23.9299610894942, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17556356, Length=581, Percent_Identity=24.6127366609294, Blast_Score=129, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=24.0963855421687, Blast_Score=88, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32564422, Length=415, Percent_Identity=22.1686746987952, Blast_Score=88, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32564420, Length=415, Percent_Identity=22.1686746987952, Blast_Score=88, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=375, Percent_Identity=24.5333333333333, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17559526, Length=532, Percent_Identity=24.4360902255639, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147511, Length=477, Percent_Identity=22.0125786163522, Blast_Score=82, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319591, Length=683, Percent_Identity=24.3045387994143, Blast_Score=153, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319699, Length=446, Percent_Identity=22.4215246636771, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648676, Length=657, Percent_Identity=27.5494672754947, Blast_Score=154, Evalue=5e-37,
Organism=Drosophila melanogaster, GI21356441, Length=491, Percent_Identity=22.1995926680244, Blast_Score=81, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24581924, Length=381, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356947, Length=403, Percent_Identity=24.8138957816377, Blast_Score=75, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013624
- InterPro:   IPR006163
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF08415 NRPS; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 151603; Mature: 151603

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFAT
CCCHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHH
LAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLG
HHCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHC
GVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVA
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEHH
DLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
HHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
ILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPAL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHCCCCCCCCCC
PTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRF
CCCCCCCHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
LLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYP
EEECCCHHCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
GLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEECCCCCEEEEEEEE
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRA
ECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
ALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLR
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
VGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPC
CCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHEEEECCCEEEEEECCCC
QVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
EEECCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTY
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
EVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGAT
HEEEEECCHHHHHHHHHHCCCCHHCEEEEEECCCCCCHHHHHHEECCCCCCHHCCCCCCH
ETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGI
HHHHHHHHEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHCCEEEECCCCC
ARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
CCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEECCCCCEEEEEEEEEEHHHH
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTL
HHHHHHCCCCHHHHHEECCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADR
CCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHH
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLPAPLTLFG
HHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
HCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTD
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCC
PVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWET
CEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCC
HTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR
CCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVHATACSEIIRAEVAELLGVRADALHPGANLVGQGLDSIRMMSLVGRWRRKGIAVDFAT
CCCHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHH
LAATPTIEAWSQLVSAGTGVAPTAVAAPGDAGLSQEGEPFPLAPMQHAMWVGRHDHQQLG
HHCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHC
GVAGHLYVEFDGARVDPDRLRAAATRLALRHPMLRVQFLPDGTQRIPPAAGSRDFPISVA
CCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCEEHH
DLRHVAPDVVDQRLAGIRDAKSHQQLDGAVFELALTLLPGERTRLHVDLDMQAADAMSYR
HHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHH
ILLADLAALYDGREPPALGYTYQEYRQAIEAEETLPQPVRDADRDWWAQRIPQLPDPPAL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHCCCCCCCCCC
PTRAGGERDRRRSTRRWHWLDPQTRDALFARARARGITPAMTLAAAFANVLARWSASSRF
CCCCCCCHHHHHCCCCEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
LLNLPLFSRQALHPDVDLLVGDFTSSLLLDVDLTGARTAAARAQAVQEALRSAAGHSAYP
EEECCCHHCCCCCCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
GLSVLRDLSRHRGTQVLAPVVFTSALGLGDLFCPDVTEQFGTPGWIISQGPQVLLDAQVT
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEECCCCCEEEEEEEE
EFDGGVLVNWDVREGVFAPGVIDAMFTHQVDELLRLAAGDDAWDAPSPSALPAAQRAVRA
ECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
ALNGRTAAPSTEALHDGFFRQAQQQPDAPAVFASSGDLSYAQLRDQASAVAAALRAAGLR
HHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
VGDTVAVLGPKTGEQVAAVLGILAAGGVYLPIGVDQPRDRAERILATGSVNLALVCGPPC
CCCEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHEEEECCCEEEEEECCCC
QVRVPVPTLLLADVLAAAPAEFVPGPSDPTALAYVLFTSGSTGEPKGVEVAHDAAMNTVE
EEECCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHH
TFIRHFELGAADRWLALATLECDMSVLDIFAALRSGGAIVVVDEAQRRDPDAWARLIDTY
HHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
EVTALNFMPGWLDMLLEVGGGRLSSLRAVAVGGDWVRPDLARRLQVQAPSARFAGLGGAT
HEEEEECCHHHHHHHHHHCCCCHHCEEEEEECCCCCCHHHHHHEECCCCCCHHCCCCCCH
ETAVHATIFEVQDAANLPPDWASVPYGVPFPNNACRVVADSGDDCPDWVAGELWVSGRGI
HHHHHHHHEEHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHCCEEEECCCCC
ARGYRGRPELTAERFVEHDGRTWYRTGDLARYWHDGTLEFVGRADHRVKISGYRVELGEI
CCCCCCCCCHHHHHHHHCCCCEEEECCCHHHHHCCCCEEEECCCCCEEEEEEEEEEHHHH
EAALQRLPGVHAAAATVLPGGSDVLAAAVCVDDAGVTAESIRQQLADLVPAHMIPRHVTL
HHHHHHCCCCHHHHHEECCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHH
LDRIPFTDSGKIDRAEVGALLAAEVERSGDRSAPYAAPRTVLQRALRRIVADILGRANDA
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VGVHDDFFALGGDSVLATQVVAGIRRWLDSPSLMVADMFAARTIAALAQLLTGREANADR
CCCCCCHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LELVAEVYLEIANMTSADVMAALDPIEQPAQPAFKPWVKRFTGTDKPGAVLVFPHAGGAA
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCHH
AAYRWLAKSLVANDVDTFVVQYPQRADRRSHPAADSIEALALELFEAGDWHLPAPLTLFG
HHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
HCMGAIVAFEFARLAERNGVPVRALWASSGQAPSTVAASGPLPTADRDVLADMVDLGGTD
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCCC
PVLLEDEEFVELLVPAVKADYRALSGYSCPPDVRIRANIHAVGGNRDHRISREMLTSWET
CEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCC
HTSGRFTLSHFDGGHFYLNDHLDAVARMVSADVR
CCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]