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The map label for this gene is mbtC [H]

Identifier: 121638261

GI number: 121638261

Start: 2635291

End: 2636625

Strand: Reverse

Name: mbtC [H]

Synonym: BCG_2396c

Alternate gene names: 121638261

Gene position: 2636625-2635291 (Counterclockwise)

Preceding gene: 121638262

Following gene: 121638260

Centisome position: 60.27

GC content: 67.27

Gene sequence:

>1335_bases
ATGTCCGATAACGACCCGGTCGTCATCGTCGGGCTGGCCATCGAGGCACCCGGTGGTGTCGAAACCGCCGACGACTACTG
GACACTGCTCTCCGAACAGCGCGAGGGACTCGGACCGTTCCCCACCGATCGAGGTTGGGCACTTCGCGAGCTGTTCGACG
GGTCGCGTCGAAACGGATTCAAACCGATCCACAACCTTGGCGGATTCCTTTCCAGCGCAACTACATTCGATCCTGAGTTC
TTCCGCATCTCACCGCGCGAGGCGACGGCGATGGACCCGCAGCAGCGGGTGGGGCTGCGAGTAGCATGGCGCACCCTGGA
GAACAGCGGGATCAATCCCGATGACCTGGCCGGTCACGATGTGGGCTGTTATGTCGGTGCCTCGGCGCTCGAATACGGTC
CCGCTTTGACCGAATTCTCCCACCACAGTGGCCATCTGATCACCGGGACGTCGCTGGGTGTCATCTCCGGGCGCATCGCC
TACACCCTTGACCTGGCCGGGCCGGCGCTGACCGTCGATACCTCGTGTTCGTCGGCGCTGGCGGCCTTTCACACCGCGGT
TCAAGCTATCCGGGCCGGCGACTGCGACCTGGCACTCGCCGGCGGCGTGTGCGTGATGGGTACGCCCGGCTATTTCGTCG
AGTTCTCCAAGCAGCACGCGCTATCCGACGACGGCCACTGCCGGCCCTACAGCGCGCACGCCAGCGGAACCGCCTGGGCA
GAGGGCGCCGCCATGTTCCTCCTGCAGCGCCGGTCGCGGGCAACCGCTGACCGGCGTCGTGTCCTCGCCGAGGTGCGTGC
CAGTTGCCTGAACTCCGATGGACTTAGCGACGGGCTGACCGCGCCCAGCGGCGACGCGCAAACGCGACTGCTCCGGCGCG
CCATCGCGCAGGCAGCAGTTGTGCCCGCCGATGTCGGGATGGTCGAAGGGCACGGCACCGCGACCCGGCTCGGCGATCGC
ACCGAATTGCGGTCACTGGCAGCCAGCTACGGCACCGCCCCGGCCGGACGCGGGCCGCTGTTGGGATCGGTCAAGTCAAA
CATCGGGCATGCTCAGGCGGCGGCGGGCGGGCTGGGCCTTGTGAAGGTCATTCTGGCCGCCCAGCACGCCGCGATCCCGC
CGACACTGCACGTCGACGAGCCCAGCCGCGAAATCGATTGGGAGAAACAGGGTCTGCGGCTGGCCGACAAACTCACGCCG
TGGCGGGCCGTTGACGGATGGCGCACCGCGGCGGTGTCCGCGTTCGGGATGAGCGGTACCAATAGCCACGTGATCGTTTC
GATGCCGGACACCGTTTCCGCGCCCGAGCGTGGCCCCGAGTGTGGGGAGGTGTGA

Upstream 100 bases:

>100_bases
GAGACTCACACCTCCGGTCGCTTCACGCTGTCGCACTTTGATGGTGGTCACTTCTATCTCAACGATCACCTCGACGCCGT
GGCCCGGATGGTGAGTGCCG

Downstream 100 bases:

>100_bases
TGGCCCCCAAACAGCTGCCCGATGGGCGGGTTGCGGTTTTGCTCAGCGCCCATGCCGAGGAACTGATCGGGCCGGACGCT
CGGGCCATCGCCGACTACCT

Product: polyketide synthetase mbtC

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase I; DEBS 1; ORF 1 [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEF
FRISPREATAMDPQQRVGLRVAWRTLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIA
YTLDLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTAWA
EGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDR
TELRSLAASYGTAPAGRGPLLGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTP
WRAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV

Sequences:

>Translated_444_residues
MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEF
FRISPREATAMDPQQRVGLRVAWRTLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIA
YTLDLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTAWA
EGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDR
TELRSLAASYGTAPAGRGPLLGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTP
WRAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV
>Mature_443_residues
SDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALRELFDGSRRNGFKPIHNLGGFLSSATTFDPEFF
RISPREATAMDPQQRVGLRVAWRTLENSGINPDDLAGHDVGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAY
TLDLAGPALTVDTSCSSALAAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTAWAE
GAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQTRLLRRAIAQAAVVPADVGMVEGHGTATRLGDRT
ELRSLAASYGTAPAGRGPLLGSVKSNIGHAQAAAGGLGLVKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTPW
RAVDGWRTAAVSAFGMSGTNSHVIVSMPDTVSAPERGPECGEV

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI41872631, Length=430, Percent_Identity=32.7906976744186, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI8923559, Length=283, Percent_Identity=27.9151943462898, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1787337, Length=289, Percent_Identity=28.0276816608997, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788663, Length=290, Percent_Identity=24.1379310344828, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=379, Percent_Identity=36.4116094986807, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17550940, Length=424, Percent_Identity=30.188679245283, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71983541, Length=277, Percent_Identity=27.0758122743682, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=27.3408239700375, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=24, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581345, Length=378, Percent_Identity=35.1851851851852, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI19920632, Length=363, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI221330659, Length=363, Percent_Identity=33.3333333333333, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24644341, Length=280, Percent_Identity=30.3571428571429, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR013968
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF08659 KR; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 46625; Mature: 46494

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALRELFDGSRRNGF
CCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
KPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVAWRTLENSGINPDDLAGHD
CHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHCCCEEEEEEHHCCCCCHHHCCCCC
VGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAYTLDLAGPALTVDTSCSSAL
CHHEECCHHHHCCCHHHHCCCCCCCEEECCCHHHCCCCEEEEEEECCCEEEEECCHHHHH
AAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTAWA
HHHHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECHHHCCCCCCCCCCCCCCCCCCCHH
EGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQTRLLRRAIAQAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
VPADVGMVEGHGTATRLGDRTELRSLAASYGTAPAGRGPLLGSVKSNIGHAQAAAGGLGL
CCCCCCEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHCCCHHH
VKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTPWRAVDGWRTAAVSAFGMSGT
HHHHHHHHHCCCCCEEECCCCCCCCCHHHHCCCHHHHCCCCHHCCCHHHHHHHHHCCCCC
NSHVIVSMPDTVSAPERGPECGEV
CCEEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDNDPVVIVGLAIEAPGGVETADDYWTLLSEQREGLGPFPTDRGWALRELFDGSRRNGF
CCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
KPIHNLGGFLSSATTFDPEFFRISPREATAMDPQQRVGLRVAWRTLENSGINPDDLAGHD
CHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCHHHHCCCEEEEEEHHCCCCCHHHCCCCC
VGCYVGASALEYGPALTEFSHHSGHLITGTSLGVISGRIAYTLDLAGPALTVDTSCSSAL
CHHEECCHHHHCCCHHHHCCCCCCCEEECCCHHHCCCCEEEEEEECCCEEEEECCHHHHH
AAFHTAVQAIRAGDCDLALAGGVCVMGTPGYFVEFSKQHALSDDGHCRPYSAHASGTAWA
HHHHHHHHHHHCCCCCEEEECCEEEECCCCCEEEECHHHCCCCCCCCCCCCCCCCCCCHH
EGAAMFLLQRRSRATADRRRVLAEVRASCLNSDGLSDGLTAPSGDAQTRLLRRAIAQAAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
VPADVGMVEGHGTATRLGDRTELRSLAASYGTAPAGRGPLLGSVKSNIGHAQAAAGGLGL
CCCCCCEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHCCCHHH
VKVILAAQHAAIPPTLHVDEPSREIDWEKQGLRLADKLTPWRAVDGWRTAAVSAFGMSGT
HHHHHHHHHCCCCCEEECCCCCCCCCHHHHCCCHHHHCCCCHHCCCHHHHHHHHHCCCCC
NSHVIVSMPDTVSAPERGPECGEV
CCEEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 8386127 [H]